H<sub>1</sub>‐ AND H<sub>2</sub>‐RECEPTORS IN THE SMOOTH MUSCLE OF THE RUMINANT STOMACH

Ohga, Akira; Taneike, Tetsuro

doi:10.1111/j.1476-5381.1978.tb08465.x

Cited by 22 publications

(18 citation statements)

References 7 publications

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“…Some authors have re ported that histamine affects stomach motil ity [26,27], Gerner et al [27] have shown on studies of isolated guinea pig stomachs that the histamine-induced activity is mediated by H| receptors. After intravenous applica tion of histamine in cats, Biancani et al [23] demonstrated in vivo phasic contractions of the pylorus with only slight effects on the antrum and duodenum.…”

Section: Discussionmentioning

confidence: 99%

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

Lüdtke

Lammel²,

Mandrek³

et al. 1991

Dig Dis

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In vitro gastric motility was investigated in 48 human and 16 canine stomachs by measuring the mechanical activity of isolated muscle strips under auxotonic conditions. For a precise regional differentiation, we recorded the mechanical activity of longitudinal and circular strips from fundus, corpus and antrum, as well as from circular preparations of the inner and outer layer of the pyloric sphincter and from the duodenum. The analysis showed that the anatomical division of the stomach into three distinct regions resulted physiologically in different patterns of contraction in vitro for each region. The fundus exhibited purely tonic spontaneous activity and a tonic contraction pattern after application of acetylcholine whereas the activity in the circular antrum was purely phasic. A combination of tonic and phasic contractions was found in the corpus and longitudinal antrum. A major difference in the basic spontaneous activity pattern was evident between man and dog. A gradient of intrinsic frequency in the stomach from proximal to distal was seen in the dog but not in man. A physiologically distinct area exists in the pyloric region of both species adjacent to the antrum and duodenum. The pyloric ring has its own spontaneous activity (minute-rhythm), reacts to the application of acetylcholine with relatively weak contractions and, unique to the dog, was delineated by histamine-induced maximal contractions. The results provide evidence that the pyloric ring is a distinct organ with specific functional characteristics in its cellular-myogenic structure.

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Section: Discussionmentioning

confidence: 99%

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

Lüdtke

Lammel²,

Mandrek³

et al. 1991

Dig Dis

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“…Contraction of the stomach in response to histamine was known to occur via the H1 receptor in the guinea pig (13) and the cat (17). As for relaxation of the bovine forestomach in response to histamine, an Hz receptor was reported to be involved (14). Taken together, these results sug-gest that histamine causes contraction via the H 1 receptor in the stomach.…”

Section: Discussionmentioning

confidence: 83%

“…It has been reported that histamine caused the contraction of guinea pig (13) and bovine (14) gastric smooth muscles. In the present study histamine stimulated obviously tonic contraction of the muscle strips from the fundus.…”

Section: Discussionmentioning

confidence: 99%

The Action of Histamine on the Isolated Stomach Muscle of the Cat

Sim

Yoon²,

Hahn³

et al. 1989

Scandinavian Journal of Gastroenterology

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The effect of histamine on contractile and electric activity was studied in the isolated stomach muscle strips of 138 cats. Histamine dose-dependently produced tonic and phasic contractions of the muscle preparations from the fundus and the corpus but only phasic contraction of the antral muscle preparations. The frequency of gastric slow waves (SWs) was also increased dose-dependently by histamine. The responses of muscle contractions and gastric SW frequency to histamine were completely blocked by pretreatment with pyrilamine (10(-6) M) and were significantly inhibited by atropine (10(-5) M) but not by cimetidine (10(-5) M), hexamethonium (10(-5) M), phentolamine (10(-5) M), or propranolol (10(-5) M). The inhibition by pyrilamine was competitive. Although atropine inhibited the effect of histamine significantly, it could not completely block the effect of histamine even at a high concentration (3 x 10(-5) M). It is concluded that histamine may participate in the regulation of gastric motility in the cat by acting on the H1 receptor to cause the release of acetylcholine and also other contractile substance(s).

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“…The distribution of these receptor subtypes is not homogeneous. For example, in the bovine and rat isolated stomach, histamine contracts or relaxes these tissues through activation of H.-or H2-receptors, respectively (Ercan & Tuirker, 1977;Ohga & Taneike, 1978). Histamine receptors responsible for contraction of the isolated guinea-pig oesophagus are mainly of the H,-receptor type with H2-receptors having a negligible role (Fujinuma et al, 1985).…”

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confidence: 99%

Effects of histamine on the guinea‐pig stomach: excitation of smooth muscle and inhibition of transmitter release

Onο

Suzuki

1987

British J Pharmacology

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The effects of histamine on electrical responses of smooth muscle cells of the guinea‐pig stomach were studied. In the fundus, histamine (above 10−6 m) depolarized the membrane and decreased the membrane resistance. In the antrum, the slow waves were enhanced by histamine, without change in the resting membrane potential or membrane resistance (10−7‐10−6 m), or with depolarization of the membrane (above 10−5 m). When the effects of histamine on neuromuscular transmission were estimated from changes in the amplitude of junction potentials, the amine (above 10−7 m) inhibited the excitatory junction potential (e.j.p.) recorded in the fundus. Inhibitory junction potentials (i.j.p.) recorded in the antrum and atropine‐treated fundus were also inhibited by histamine. Repolarization of the histamine‐induced depolarization to the resting potential level did not restore the amplitude of the e.j.p. to the control value. These actions of histamine on the smooth muscle cells and on junction potentials were inhibited by either mepyramine or cimetidine, agents which block the H1‐ and H2‐receptor, respectively. It is concluded that in the guinea‐pig stomach, histamine exerts a direct excitatory effect on the smooth muscle cells and has inhibitory actions on cholinergic excitatory and non‐adrenergic, non‐cholinergic inhibitory transmission.

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H₁‐ AND H₂‐RECEPTORS IN THE SMOOTH MUSCLE OF THE RUMINANT STOMACH

Cited by 22 publications

References 7 publications

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

The Action of Histamine on the Isolated Stomach Muscle of the Cat

Effects of histamine on the guinea‐pig stomach: excitation of smooth muscle and inhibition of transmitter release

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H1‐ AND H2‐RECEPTORS IN THE SMOOTH MUSCLE OF THE RUMINANT STOMACH

Cited by 22 publications

References 7 publications

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

Myogenic Basis of Motility in the Pyloric Region of Human and Canine Stomachs

The Action of Histamine on the Isolated Stomach Muscle of the Cat

Effects of histamine on the guinea‐pig stomach: excitation of smooth muscle and inhibition of transmitter release

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H₁‐ AND H₂‐RECEPTORS IN THE SMOOTH MUSCLE OF THE RUMINANT STOMACH