The Action of Histamine on the Isolated Stomach Muscle of the Cat

Abstract

The effect of histamine on contractile and electric activity was studied in the isolated stomach muscle strips of 138 cats. Histamine dose-dependently produced tonic and phasic contractions of the muscle preparations from the fundus and the corpus but only phasic contraction of the antral muscle preparations. The frequency of gastric slow waves (SWs) was also increased dose-dependently by histamine. The responses of muscle contractions and gastric SW frequency to histamine were completely blocked by pretreatment with pyrilamine (10(-6) M) and were significantly inhibited by atropine (10(-5) M) but not by cimetidine (10(-5) M), hexamethonium (10(-5) M), phentolamine (10(-5) M), or propranolol (10(-5) M). The inhibition by pyrilamine was competitive. Although atropine inhibited the effect of histamine significantly, it could not completely block the effect of histamine even at a high concentration (3 x 10(-5) M). It is concluded that histamine may participate in the regulation of gastric motility in the cat by acting on the H1 receptor to cause the release of acetylcholine and also other contractile substance(s).

Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum

“…In the guinea‐pig small intestine, there is evidence that histamine H 3 receptors are involved in the presynaptic inhibition of cholinergic nerve activity ( Trzeciakowski, 1987 ; Tamura et al ., 1988 ; Poli et al ., 1991 ) but enteric synaptic transmission in this species is modulated by H 1 , H 2 and H 3 receptors ( Izzo et al ., 1998 ). Histamine acting on neuronal H 1 receptors also modulates cholinergic nerve activity in the myenteric plexus of the rat small intestine and in the cat stomach ( Sakai, 1979 ; Sim et al ., 1989 ). This suggests that histamine H 1 receptors may play a role in enteric cholinergic neurotransmission but that their role and importance may depend upon the species and tissue under study.…”

Evidence for tetrodotoxin‐resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine

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Are itch and scratching the nausea and vomiting of skin?

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