H. pylori Infection, Inflammation and Gastric Cancer

Qadri, Qurteeba; Rasool, Roohi; Gulzar, Ghulam Mohammad; Naqash, Sameer H.; Shah, Zafar A.

doi:10.1007/s12029-014-9583-1

Cited by 50 publications

(45 citation statements)

References 83 publications

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“…Inflammation is strongly associated with tumor development, including GC (4,6,20). Chronic inflammation induces immunosuppression and cancer (21).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have confirmed that Helicobacter pylori (H. pylori) infection, inflammation, immune development and genetic factors are closely associated with human GC (4,5). H. pylori is responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia and GC (6,7).…”

Section: Introductionmentioning

confidence: 98%

“…H. pylori is responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia and GC (6,7). The mechanism of H. pylori inducing GC potentially involves chronic inflammation (8) or the action of H. pylori virulence factors (4,9). Furthermore, genetic variation in the Fas signaling pathway is correlated with the risk of GC (10).…”

Section: Introductionmentioning

confidence: 99%

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Effect of interleukin-1β and tumor necrosis factor α gene silencing on mouse gastric cancer cell proliferation and migration

et al. 2016

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Abstract. The aim of the present study was to investigate the effect of interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα) gene co-silencing in mouse gastric cancer (GC) cells. Respectively, three pairs of liposome-encapsulated IL-1β and TNFα small interfering RNA (siRNA) were transfected into the mouse GC cell line MFC. The most effective siRNA, as identified by reverse transcription-polymerase chain reaction, was used for co-suppression of IL-1β and TNFα genes. The activities of cell proliferation, colony formation and migration were determined by the Cell Counting Kit 8 method, colony formation assay and Transwell assay, respectively. Protein array analysis was performed to identify the differentially expressed factors. The possible signaling pathways of the various factors targeting the genes were identified by pathway enrichment analysis using KOBAS 2.0. siRNA1 and siRNAc were the most effective interference sequences for IL-1β and TNFα, respectively. Following co-transfection of siRNA1 and siRNAc, the expression of IL-1β and TNFα was inhibited at the mRNA and protein levels, and the cell proliferation, colony forming and migration abilities were reduced (P<0.05). The expression of inflammatory factors, including chemokine ligand 5, cyclooxygenase-2, IL-6, transforming growth factor β, IL-17A, matrix metallopeptidase 9 and stromal cell-derived factor 1α were also inhibited (P<0.05). These factors are mainly involved in the rheumatoid arthritis pathway, the intestinal immune network for IgA production, the TNF signaling pathway and the inflammatory bowel disease pathway. IL-1β and TNFα gene silencing inhibits the proliferation and migration of MFC. The mechanisms may involve multiple inflammatory factors that participate in the signaling pathways of tumor tissue inflammation, the immune

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“…Inflammation is strongly associated with tumor development, including GC (4,6,20). Chronic inflammation induces immunosuppression and cancer (21).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Effect of interleukin-1β and tumor necrosis factor α gene silencing on mouse gastric cancer cell proliferation and migration

et al. 2016

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“…Helicobacter pylori infection of the gastric mucosa results in gastritis in the majority of infected individuals (1). This infection is a major cause of peptic ulcer disease (PUD) and an important causative factor for gastric cancer (GC) (1).…”

Section: Introductionmentioning

confidence: 99%

“…This infection is a major cause of peptic ulcer disease (PUD) and an important causative factor for gastric cancer (GC) (1). GC is the second most common cause of cancer-associated mortalities and is one of the most prevalent malignancies worldwide (2).…”

Section: Introductionmentioning

confidence: 99%

Variations in the multimerization region of the Helicobacter pylori cytotoxin CagA affect virulence

2017

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Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer

Shao

Jiang

et al. 2014

Cancer

166

143

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BACKGROUND: Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA-AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis. METHODS: Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real-time reverse transcriptase-polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls. RESULTS: Expression levels of AA174084 were down-regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P < .001). AA174084 levels had significant, negative correlations with age (P 5 .031), Borrmann type (P 5 .016), and perineural invasion (P 5 .032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P < .001) and were associated with invasion (P 5 .049) and lymphatic metastasis (P 5 .042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P < .001). The area under ROC was up to 0.848 (P < .001). CONCLUSIONS: AA174084 may have potential as marker for the early diagnosis of GC. Cancer 2014;120:3320-9.

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H. pylori Infection, Inflammation and Gastric Cancer

Abstract: Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.

Cited by 50 publications

References 83 publications

Effect of interleukin-1β and tumor necrosis factor α gene silencing on mouse gastric cancer cell proliferation and migration

Effect of interleukin-1β and tumor necrosis factor α gene silencing on mouse gastric cancer cell proliferation and migration

Variations in the multimerization region of the Helicobacter pylori cytotoxin CagA affect virulence

Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer

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