1982
DOI: 10.1111/j.1471-4159.1982.tb05359.x
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H‐Pro‐[3H]Leu‐Gly‐NH2: Plasma Profile and Brain Uptake Following Subcutaneous Injection in the Rat

Abstract: Following subcutaneous injection of the tripeptide H-Pro-[3H]Leu-Gly-NH2 ([3H]PLG) in rats, the profile of intact peptide and its radioactively labeled metabolites was examined both in plasma and in brain tissue. [3H]PLG and metabolites were determined in trichloroacetic acid extracts by reverse-phase paired-ion HPLC. Maximal plasma levels of unmetabolized PLG were reached 6-8 min after administration, after which they decreased with an elimination half-life of 20 min. The uptake of [3H]PLG in the brain ranged… Show more

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Cited by 10 publications
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