h-Caldesmon Expression Effectively Distinguishes Endometrial Stromal Tumors From Uterine Smooth Muscle Tumors

Nucci, Marisa R.; O'Connell, Jerome T.; Huettner, Phyllis C.; Čviko, Aida; Sun, Deqiang; Quade, Bradley J.

doi:10.1097/00000478-200104000-00004

Cited by 158 publications

(75 citation statements)

References 29 publications

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“…Five of 6 cases were positive for CD10, representing a percentage of immunoreactive cases similar to that reported in the literature [4,[6][7][8][9][10]. Focal staining for desmin was present in 4 cases, similar to what has been previously described by several groups [32,33]. All cases were negative for h-caldesmon, which has been reported to have utility for differentiating ESS from other entities such as cellular leiomyoma [33].…”

Section: Discussionsupporting

confidence: 77%

JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma

et al. 2011

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Section: Discussionsupporting

confidence: 77%

JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma

et al. 2011

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“…Interestingly, another tumor (case 3) in a series of nine uterine leiomyomata with 10q22 rearrangements was classified as a cellular uterine leiomyomata (12). Cellular leiomyoma, such as those in this report, are of concern because they morphologically mimic malignant endometrial stromal sarcomas (24). In addition, an uterine leiomyosarcoma in which the sole abnormality was t(10;17) might have been misclassified and may actually belong with this group of histologically unusual uterine leiomyomata.…”

Section: Discussionmentioning

confidence: 73%

Uterine Leiomyomata with t(10;17) Disrupt the Histone Acetyltransferase MORF

Herrick²,

et al. 2004

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Benign uterine leiomyomata are the most common tumors in women of reproductive age. One recurring chromosomal aberration in uterine leiomyomata is rearrangement of 10q22. Chromosome 10 breakpoints were mapped by fluorescence in situ hybridization to intervals ranging from 8.9 to 72.1 kb within the third intron of MORF (monocytic leukemia zinc finger protein-related factor or MYST4) in four uterine leiomyomata tested. Additional Southern hybridization experiments confirmed that the breakpoint lies within the third intron and narrowed the interval to 2.1 kb in one uterine leiomyomata. MORF is a member of the MYST family of histone acetyltransferase and previously has been found rearranged in some types of acute myeloid leukemia (AML). This is the first instance in which disruption of a histone acetyltransferase has been reported in another tumor type. The breakpoints in uterine leiomyomata would fall in the NH 2 -terminal portion of the protein between a conserved domain found in histones H1 and H5 and the PHD zinc fingers, the CH2CH zinc finger, or the CoA binding site, which is distinct from the breakpoints reported in AML. Mapping of the 17q21 breakpoint by fluorescence in situ hybridization within a specific region in three tumors revealed several positional candidates including GCN5L2, a gene with histone acetyltransferase activity similar to those fused to MORF in AML. Of note, two of three uterine leiomyomata were of the cellular subtype. Involvement of MORF in four uterine leiomyomata with chromosomal rearrangements involving 10q22 and 17q21 suggests a role for this histone acetyltransferase and altered chromatin regulation in uterine mesenchymal neoplasia.

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“…However, occasional smooth muscle differentiation in ESS as represented by expression of ␣-SMA and/or desmin (24 -26) may lead to an erroneous interpretation of the results of immunohistochemistry. h-Caldesmon is considered to be a specific smooth muscle marker that is positive in welldifferentiated smooth muscle cells and negative even in desmin-and/or ␣-SMA-positive ESS and thus is considered to be useful in distinguishing smooth muscle tumor from ESS (27,28). Therefore, currently a panel employing a combination of CD10 and h-caldesmon seems contributory in making the distinction between ESS and smooth muscle tumor.…”

Section: Discussionmentioning

confidence: 99%

Expression of CD10 in Malignant Müllerian Mixed Tumors and Adenosarcomas: An Immunohistochemical Study

et al. 2002

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CD10 has been demonstrated to be positive in endometrial stromal sarcoma (ESS) and thus is useful in establishing the diagnosis, but its expression in malignant müllerian mixed tumor (MMMT) and müllerian adenosarcoma remains to be clarified. In this study, 12 cases of MMMT (9 uterine, 2 tubal, and 1 metastatic), 6 cases of müllerian adenosarcoma (three corporeal, two cervical, and one tubal), and 7 cases of primary uterine sarcomas had their tissues examined immunohistochemically for expression of CD10, desmin, myoglobin, ␣-smooth muscle actin (SMA), and cytokeratin. Of the primary uterine sarcomas, two were primary rhabdomyosarcomas (one cervical and one corporeal), two were ESSs, two were high-grade leiomyosarcomas, and one was a high-grade endometrial sarcoma. Sarcomatous components in all cases of MMMT and müllerian adenosarcoma, as well as all uterine sarcomas, were positive for CD10, showing moderate to marked staining intensity with varying distribution except in one MMMT, which showed weak and very focal staining. In four MMMTs, three adenosarcomas, and one rhabdomyosarcoma, myoglobinand/or desmin-positive rhabdomyoblastic cells were positive for CD10. The immunoreactivity for CD10 showed the same distribution for ␣-SMA and myoglobin in three and two MMMTs, respectively. In five cases of MMMT, carcinomatous components were focally positive for CD10, and in two cases small populations of round or short spindle cells in sarcomatous components were positive for CD10, ␣-SMA, and cytokeratin (CAM5.2). These results indicate that CD10 expression is not restricted to ESS

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h-Caldesmon Expression Effectively Distinguishes Endometrial Stromal Tumors From Uterine Smooth Muscle Tumors

Cited by 158 publications

References 29 publications

JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma

JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma

Uterine Leiomyomata with t(10;17) Disrupt the Histone Acetyltransferase MORF

Expression of CD10 in Malignant Müllerian Mixed Tumors and Adenosarcomas: An Immunohistochemical Study

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