Gynecomastia, Prolactin, and Other Peptide Hormones in Patients Undergoing Chronic Hemodialysis

Nagel, Theodore C.; Freinkel, Norbert; Bell, Randy; Friesen, Henry G.; Wilber, John F.; Metzger, Boyd E.

doi:10.1210/jcem-36-3-428

Cited by 83 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After TRH injection, serum TSH concentration rose rapidly in seven normal subjects, reached a peak by 30 min, and returned to basal levels in 3 h. Of the seven HD patients tested, one showed no increase in serum TSH concentration, four had a blunted response, and the other two showed a low normal response. In the latter, the peak was delayed until [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] min, and TSH levels remained elevated for more than 3 h (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Thyroid Dysfunction in Chronic Renal Failure

Lim¹,

Fang²,

Katz³

et al. 1977

J. Clin. Invest.

219

View full text Add to dashboard Cite

A B S T R A C T Thyroid function was evaluated in 46patients with end-stage kidney disease and 42 normal subjects. Patients were studied before and after the institution of maintenance hemodialysis (HD) and after renal transplantation (RT). Serum total triiodothyronine concentrations (TT3, ng/100 ml, mean± SD) were 63±17 and 83±22 in the non-HD and HD groups, respectively. Values from normal subjects were 128±25 and from RT patients 134±20. The TT3 was in the hypothyroid range (<78 ng/100 ml; 2 SD below normal mean) in 80% of non-HD and 43% of HD patients. Mean serum total thyroxine concentration (TT4), although within the normal range, was lower than the control value. T4-binding globulin capacity was also slightly lower but the difference was not statistically significant. Among patients whose TT4 was 1 SD below the normal mean, the free T4 index was equally depressed, suggesting that factors other than decreased binding capacity might be responsible for the low TT4. In addition, there was a 37% incidence of goiter. Mean serum thyroid-stimulating hormone (TSH) was not elevated and the TSH response to thyrotropinreleasing hormone (TRH) was distinctly blunted, suggesting the possibility of pituitary dysfunction as well. In vivo '25I-L-T4 and 13'I-L-T3 kinetics during 0.2 mg/day of L-T4 replacement showed marked reduction in T3 turnover rate in the uremic patients, both before and during HD; the values (,tg T3/day, mean±SD) for the different groups were as follows: normal, 33.8+6.1; non-HD, 13.5±2.6; HD, 12.9±3.1; and RT, 30.3±7.1.The low T3 turnover rate was due to impaired extrathyroidal conversion of T4 to T3. The mean perThis work was presented in part at the 50th Annual

show abstract

Section: Resultsmentioning

confidence: 99%

Thyroid Dysfunction in Chronic Renal Failure

Lim¹,

Fang²,

Katz³

et al. 1977

J. Clin. Invest.

219

View full text Add to dashboard Cite

show abstract

“…In the majority of the patients with renal failure, and partic ularly in the women, the levels of prolactin are high [37], Hyperprolactinemia may be responsible for some abnor malities of the pituitary-gonadal axis commonly observed in these patients. The majority of the women do not show any surge in luteinizing hormone releases at the middle of the menstrual cycle, and the ovarian function is also impaired, with low concentrations of estrogen and proges terone [38].…”

Section: Discussionmentioning

confidence: 99%

Neutral-Lipid Transfers and Cholesteryl Ester Transfer Protein in Hemodialyzed Patients

et al. 1996

View full text Add to dashboard Cite

Abnormalities in cholesteryl ester transfers may play a role in the development of atherosclerosis observed in patients with end-stage renal failure treated by chronic hemodialysis. Net neutral-lipid transfers and cholesteryl ester transfer protein activity and mass were investigated in 20 hemodialyzed patients, arbitrarily divided into two groups based on fasting triglyceride levels, and compared to triglyceride-matched control groups. In the hypertriglyceridemic subjects (plasma triglyceride values > 150 mg/dl), high-density lipoprotein cholesterol was decreased, and the net cholesteryl ester transfer rates were significantly higher than the rates in normolipidemic subjects. The comparison of subjects matched for plasma triglyceride and cholesterol levels showed no significant difference in cholesteryl ester or triglyceride transfer rates between patients and controls. Our results suggest that normal or elevated net neutral-lipid transfers are not related to the renal status of the subjects, but rather to their plasma triglyceride levels.

show abstract

“…Baseline serum prolactin (PRL) is also increased in about 50% of males with chronic renal failure, whether or not on RDT [11,[15][16][17][18][19][20], In the same patients the circa dian variation of pituitary secretion of PRL is abolished [11], and the response to thyro tropin-releasing hormone (TRH) is blunted [8], This endocrine pattern points to a cen tral regulatory abnormality of PRL synthesis which is not reversed by RDT [16]. Addi tional endocrine findings in males are low adrenal androgen [21] and low to normal total and free estrogen levels [3].…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

“…Compared to males, less information on sexual hormone patterns is available, due to the need for time-con suming serial measurements throughout the menstrual cycle. Baseline serum estrogen levels seem lower than normal [32], particulary when hyperprolactinemia is also present which is the case in over 70% of premeno pausal women on RDT [11,[15][16][17][18][19]33], As far as the central feedback control is con cerned, baseline gonadotropin and LH-RH levels during the first half of the cycle are elevated [ 13], but the midcycle peaks of LH and LH-RH are lacking in most cases, with ensuing anovulatory cycle and low progester one levels during the second part of the cycle [27].…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Hormonal Changes in Hemodialysis

Bonomini¹,

Orsoni²,

Sorrentino³

et al. 1990

Blood Purif

View full text Add to dashboard Cite

When chronic renal failure becomes advanced, the serum or tissue levels and/or the functions of most hormones are altered because of several interplaying mechanisms involving synthesis, transport, accumulation of inhibitors, abnormality of target organ responsiveness, and impaired renal clearance. As regular dialysis treatment is performed, most of these uremic hormone abnormalities are not reversed, and some of them may even get worse. The main endocrine derangements can be grouped as sexual hormone dysfunction, thyroid abnormalities, growth retardation, hormone-related disorders of metabolism, derangements of pressor substances, gastrointestinal peptide abnormalities, renal osteodystrophy, and anemia. The endocrine abnormalities play a major role as for the clinical and metabolic rehabilitation of dialysis patients.

show abstract

Gynecomastia, Prolactin, and Other Peptide Hormones in Patients Undergoing Chronic Hemodialysis

Cited by 83 publications

References 0 publications

Thyroid Dysfunction in Chronic Renal Failure

Thyroid Dysfunction in Chronic Renal Failure

Neutral-Lipid Transfers and Cholesteryl Ester Transfer Protein in Hemodialyzed Patients

Hormonal Changes in Hemodialysis

Contact Info

Product

Resources

About