Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls

Elizondo‐Montemayor, Leticia; Hernández-Escobar, Claudia E.; Lara‐Torre, Eduardo; Nieblas, Bianca; Gómez-Carmona, Merith

doi:10.1016/j.jpag.2016.02.007

Cited by 48 publications

(36 citation statements)

References 180 publications

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“…В доступной литературе отсутствуют данные проспективных исследований девочек с ГД, что является актуальным в связи с высокой частотой данного заболевания в пубертатном периоде [1,3]. Большинство авторов учитывают лишь ожирение в пубертатном периоде и его негативное влияние на репродуктивную функцию [8,10].…”

Section: Discussionunclassified

“…Гормо-нальные и метаболические нарушения у женщин с ожирением определяются как основные факторы, увеличивающие частоту ановуляции и бесплодия [2,6,7,10]. Единичные проспективные исследования по-казывают последствия ожирения в пубертатном пе-риоде на репродуктивную систему и ограничиваются нарушениями менструального цикла и ановуляцией [8]. Вместе с тем длительное течение заболевания с пубертатного периода может способствовать нару-шению рецептивности в эндометрии и приводить к нарушению имплантации.…”

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Basic Mechanisms of Primary Infertility in Reproductive Age Women With Hypothalamic Dysfunction in Puberty

Жуковец¹,

Leshchenko²,

Аталян³

et al. 2017

Acta Biomedica Scientifica

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Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease in fertility in women.The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170)

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Section: Discussionunclassified

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Basic Mechanisms of Primary Infertility in Reproductive Age Women With Hypothalamic Dysfunction in Puberty

Жуковец¹,

Leshchenko²,

Аталян³

et al. 2017

Acta Biomedica Scientifica

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“…17,33 The length of perimenarche is strongly influenced by socioeconomic factors and metabolic variables, such as nutritional status and body mass index (BMI). [34][35][36] Hence, disorders that accelerate H-P-O maturation, such as obesity, Bold denotes control population.…”

Section: Clinical Opinionmentioning

confidence: 99%

The impact of uterine immaturity on obstetrical syndromes during adolescence

Brosens

Muter

Gargett

et al. 2017

American Journal of Obstetrics and Gynecology

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Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence. In addition to ontogenetic progesterone resistance, other factors appear important for the transition of the immature uterus to a functional organ, including estrogen-dependent growth and tissue-specific conditioning of uterine natural killer cells, which plays a critical role in vascular adaptation during pregnancy. The perivascular space around the spiral arteries is rich in endometrial mesenchymal stem-like cells, and dynamic changes in this niche are essential to accommodate endovascular trophoblast invasion and deep placentation. Here we evaluate the intrinsic (uterine-specific) mechanisms that predispose adolescent mothers to the great obstetrical syndromes and discuss the convergence of extrinsic risk factors that may be amenable to intervention.

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“…An early miscarriage more often occurs among patients with obesity 5 . Furthermore, the increased body weight correlates with the risk of unfavourable maternal outcomes, such as gestational hypertension, gestational diabetes mellitus (GDM), Caesarean section, intrauterine infections, thrombotic complications or postpartum haemorrhage 6–9 . Gravidas with overweight and obesity should receive special attention because increased body mass is a major determinant of the offspring health during childhood and later adult life.…”

Section: Introductionmentioning

confidence: 99%

Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?

et al. 2020

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Overweight and obesity have become a dangerous disease requiring multiple interventions, treatment and preventions. In women of reproductive age, obesity is one of the most common medical conditions. Among others, obese state is characterized by low-grade systemic inflammation and enhanced oxidative stress. Increased maternal body mass index might amplify inflammation and reactive oxygen species production, which is associated with unfavourable clinical outcomes that affect both mother and child. Intrauterine growth retardation, preeclampsia, or gestational diabetes mellitus are examples of the hampered maternal and foetoplacental unit interactions. Visfatin is the obesity-related adipokine produced mainly by the visceral adipose tissue.Visfatin affects glucose homeostasis, as well as the regulation of genes related to oxidative stress and inflammatory response. Here, we review visfatin interactions in pregnancy-related disorders linked to obesity. We highlight the possible predictive and prognostic value of visfatin in diagnostic strategies on gravidas with obesity. K E Y W O R D S obesity, pregnancy, visfatin

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Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls

Cited by 48 publications

References 180 publications

Basic Mechanisms of Primary Infertility in Reproductive Age Women With Hypothalamic Dysfunction in Puberty

Basic Mechanisms of Primary Infertility in Reproductive Age Women With Hypothalamic Dysfunction in Puberty

The impact of uterine immaturity on obstetrical syndromes during adolescence

Can adipokine visfatin be a novel marker of pregnancy‐related disorders in women with obesity?

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