Gynecologic amyloidosis

Copeland, William E.; Hawley, Philip C.; Teteris, Nicholas J.

doi:10.1016/0002-9378(85)90472-7

Cited by 18 publications

(10 citation statements)

References 1 publication

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“…Currently, there is no effective treatment for prevention of fibrillogenesis or mobilisation of established amyloid deposits 1 . Logically, the treatment is primarily aimed at the underlying predisposing condition to prevent overproduction of the precursor proteins or subsequent tissue deposition 2,4 …”

Section: Discussionmentioning

confidence: 99%

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Primary localised amyloidosis of the vagina

Pehlivanov¹,

Belovegdov²,

Ivanov³

et al. 2008

Aust NZ J Obst Gynaeco

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Section: Discussionmentioning

confidence: 99%

“…Cases involving the reproductive tract are rare. Only 12 cases of cervical amyloid, 3–7 four cases of uterine amyloid and one case of systemic amyloidosis with endometrial involvement are reported in the literature 8 …”

Section: Introductionmentioning

confidence: 99%

Primary localised amyloidosis of the vagina

Pehlivanov¹,

Belovegdov²,

Ivanov³

et al. 2008

Aust NZ J Obst Gynaeco

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“…Cases of amyloidosis affecting the female genital tract have been described before and have been associated with menorrhagia 2–4 . Postmenopausal bleeding has also been associated with isolated amyloid deposition to the uterine cervix 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Postmenopausal bleeding has also been associated with isolated amyloid deposition to the uterine cervix 5 . Massive amyloidosis affecting the complete uterus, tubes and ovaries has been reported in a surgical specimen obtained at hysterectomy, but was not associated with postmenopausal bleeding 3 . Bleeding diathesis in amyloidosis is most likely caused by increased fragility and impaired contractility of blood vessels due to deposition of amyloid underneath the endothelium 6 .…”

Section: Discussionmentioning

confidence: 99%

Uterine amyloidosis in menopause

Jongen

Grond²,

Veelen

et al. 1998

BJOG

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A 78 year old woman was admitted to our hospital because of postmenopausal bleeding. Cervical dilatation and uterine curettage appeared to be impossible due to a very narrow vaginal introitus after an anterior colporrhaphy. Transrectal ultrasonography revealed highly reflective scattering densities of a punctate nature (Fig. 1). As bleeding persisted and endometrial pathology could not be excluded, an abdominal hysterectomy was performed. During a difficult operation a crumbly irregular uterus, bleeding on every touch, was removed accompanied by bilateral salpingo-oophorectomy. Total blood loss during the procedure amounted to 4 L. Apart from blood transfusion the post-operative course was uneventful.The surgical specimen consisted of a 88 g uterus with frayed and crumbly ovaries and fallopian tubes. Histologically, the endometrium was atrophic, no hyperplasia or carcinoma was found (endometrial thickness < I mm). However, massive deposits of amorphous, eosinophilic substance were found in the myometrial stroma with encroachment on smooth muscle cells and local atrophy, and in vessel walls of the uterine corpus and fallopian tubes (Fig. 2). The left ovary was normal. The right ovary could not be identified. Some deposits had elicited a foreign body giant cell reaction and metaplastic bone formation. Congo red stains imparted a pinkish colour to the deposits and showed green birefringence with cross-polarised light consistent with amyloid. The amyloid deposits were found to be resistant to pretreatment with potassium permanganate. Immunostaining with antibodies to serum amyloid A protein, prealbumin and p 2 microglobulin were negative. These observations are consistent with immunoglobulin light chain-derived (AL) amyloidosis. Subsequent extensive haematological analysis did not reveal a plasma cell dyscrasia or any other B-cell neoplasm. Repeated urinanalyses for Bence Jones proteins were negative and serum immunoelectrophoresis and quantitative immunoglobulins findings were normal. Thor-

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“…Some of these patients also suffer from skin lesions and arthritis. Amyloidosis may complicate up to 2 5 % of FMF patients [ 1 ] and in these patients several kinships with autosomal dominant in heritance were reported [2], [10] et al [12] Pfanner [11] and Levin [13] uterus, tubes and ovaries was also reported [4]. During pregnancy, FMF bouts usually lessen [5,6], However, a 30% fetal wastage was reported [5].…”

Section: Introductionmentioning

confidence: 99%

Successful Full-Term Pregnancy in Familial Mediterranean Fever Complicated with Amyloidosis: Case Report and Review of the Literature

Mordel¹,

Birkenfeld²,

Rubinger

et al. 1993

Fetal Diagn Ther

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Pregnancy during familial Mediterranean fever complicated with amyloidosis and severe nephrotic syndrome is rare and may cause several maternal and fetal complications. Asymmetrical intrauterine growth retardation, superimposed pre-eclampsia, thromboembolic phenomena, resistant anemia and renal failure only partially represent the possible complications. A successful outcome of a full-term pregnancy is presented and the efficiency of colchicine, a high protein diet, acetylsalicylic acid and dipyridamole is discussed.

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Gynecologic amyloidosis

Cited by 18 publications

References 1 publication

Primary localised amyloidosis of the vagina

Primary localised amyloidosis of the vagina

Uterine amyloidosis in menopause

Successful Full-Term Pregnancy in Familial Mediterranean Fever Complicated with Amyloidosis: Case Report and Review of the Literature

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