Gynandroblastoma its ultrastructure

Abstract

Gynandroblastoma is a rare, sex‐cord stromal tumor of the ovary that shows morphologic evidence of female and male differentiation. Such a tumor produced masculinization in a 24‐year‐old woman, whose symptoms disappeared following removal of the tumor. By electron microscopy, the granulosa cell nests displayed Call‐Exner (CE) bodies of the hyaline type composed of multiple layers of basal lamina resembling CE bodies of the normal graafian follicle. In contrast, CE bodies of a classic granulosa theca cell tumor were of the spongiform type, consisting of a space limited by a single basal lamina containing altered granulosa cells and cell processes. Both types of CE bodies to arise following secretion by and/or degeneration of granulosa cells, the variation in morphology between the two resulting from differences in amounts of basal lamina deposited. The tubular components of the tumor resembled more closely the rete ovarii than they did Sertoli cells, and it is proposed that such structures be called by the alternate and less specific term “androblastoma.” The identity of Leydig cells was established by demonstration of intracytoplasmic Reinke crystals. Despite a difference in architectural pattern, there was a close ultrastructural resemblance between the different sex‐cord components of the gynandroblastoma.

Cutaneous Granulomatous Vasculitis: Presenting Feature of Crohn's Disease

“…Granulomatous vasculitis can occasionally be seen in the intestinal lesions of Crohn's disease and it has been suggested that the reaction may represent an immune response to antigen localized within the vessel wall (Thompson 1983). However, complement and immunoglobulin have not been identified within the vessel walls of our case by immunoperoxidase stains, and this negative observation was also made in one of the previous cases of granulomatous vasculitis using immunofluorescence (Chalvardjian & Nethercott 1982).…”

“…In addition, cutaneous necrotizing vasculitis has been described in association with idiopathic inflammatory bowel disease. It has been reported in occasional patients with ulcerative colitis (Callen 1979) and to date in a total of 8 patients with Crohn's disease (Dyer et al 1970), Verbov & Stansfield 1972, Burgdorf& Orkin 1981, Chalvardjian & Nethercott 1982. In a series including 6 of these patients, the vascular changes were interpreted as representing coexistent cutaneous polyarteritis nodosa (Dyer et al 1970, Verbov & Stansfield 1972.…”

“…It is of interest that in one case the inflammation was described as granulomatous. The remaining 2 of the 8 patients showed cutaneous granulomatous vasculitis and this was considered to be a manifestation of Crohn's disease (Burgdorf & Orkin 1981, Chalvardjian & Nethercott 1982. In both of these cases the diagnosis of Crohn's disease had been established 14 years previously.…”

Bilateral Pelviureteric Junction Obstruction: The Case for Endoscopic Management

“…In addition, cutaneous necrotizing vasculitis has been described in association with idiopathic inflammatory bowel disease. It has been reported in occasional patients with ulcerative colitis (Callen 1979) and to date in a total of 8 patients with Crohn's disease (Dyer et al 1970), Verbov & Stansfield 1972, Burgdorf& Orkin 1981, Chalvardjian & Nethercott 1982. In a series including 6 of these patients, the vascular changes were interpreted as representing coexistent cutaneous polyarteritis nodosa (Dyer et al 1970, Verbov & Stansfield 1972.…”

“…It is of interest that in one case the inflammation was described as granulomatous. The remaining 2 of the 8 patients showed cutaneous granulomatous vasculitis and this was considered to be a manifestation of Crohn's disease (Burgdorf & Orkin 1981, Chalvardjian & Nethercott 1982. In both of these cases the diagnosis of Crohn's disease had been established 14 years previously.…”