Gynaecological effects of tamoxifen.

Ismail, Sharif I. M. F.

doi:10.1136/jcp.52.2.83

Cited by 37 publications

(16 citation statements)

References 80 publications

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“…genotoxic in the rat liver and isolated hepatocytes, forming 4 To whom correspondence should be addressed persistent DNA adducts in vivo (6,(8)(9)(10)(11). Tamoxifen forms Email: bkpark@liv.ac.uk similar adducts in murine hepatocytes (8,12) but they are Tamoxifen is a hepatic genotoxin in rats and mice but a produced at lower concentrations and are less persistent in vivo hepatocarcinogen only in rats.…”

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confidence: 99%

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts

et al. 2000

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confidence: 99%

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts

et al. 2000

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“…Verschiedene Autoren konnten z. T. in Untersuchungen an großen Kollektiven [2,3] zeigen, dass eine Abhängigkeit besteht (Übersicht bei Suh-Burgmann [4]). Andere verneinen aber einen solchen Zusammenhang [5].…”

Section: Abstract: Tam -Endometrium -Endometrial Cancer -Transvaginaunclassified

Sonographische Endometriumkontrolle unter Tamoxifen: Wirklich nicht empfehlenswert oder doch sinnvoll?

Burkart¹,

Wight²,

J³

et al. 2001

Ultraschall in Med

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To detect early premalignant or malignant changes of the endometrium, we recommend histological examination by hysteroscopy and dilatation and curettage when the endometrium is > 8 mm thick, even in the absence of symptoms. Therefore, these patients should have regular examinations by transvaginal ultrasound once or twice a year. Moreover, continuing regular screening of the endometrium for years after termination of tamoxifen-therapy is also to be recommended.

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“…Well known conditions, such as tubo-endometrial metaplasia in the cervix, which in many cases can be viewed as an iatrogenic lesion induced by prior trauma, are not discussed. The effects of various hormonal preparations and of tamoxifen on the endometrium are well known and have been the subject of several reviews 1 – 3. These will not be discussed, except for selected agents and recently described lesions.…”

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confidence: 99%

Iatrogenic lesions and artefacts in gynaecological pathology

Clarke

McCluggage²

2008

J Clin Pathol

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Increasingly in the field of medicine, new therapeutic modalities, both surgical and non-surgical, are being introduced. Some of these may significantly alter the pathological appearance of normal and neoplastic tissue and result in problems for the pathologist. In this review, iatrogenic pathology within the female genital tract is described, especially concentrating on the recent literature. Pathological artefacts within the female genital tract are also reviewed. Topics covered include mechanical displacement of normal and neoplastic elements into vascular or tissue spaces and thermal artefacts. Recently described pathological findings in neoplastic and non-neoplastic tissue secondary to hormonal, chemotherapeutic and other medications are discussed. Changes associated with non-surgical management of uterine leiomyomas are also described. It behoves the pathologist to be aware of these iatrogenic lesions and artefacts in order to prevent diagnostic errors.

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Gynaecological effects of tamoxifen.

Cited by 37 publications

References 80 publications

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts

Sonographische Endometriumkontrolle unter Tamoxifen: Wirklich nicht empfehlenswert oder doch sinnvoll?

Iatrogenic lesions and artefacts in gynaecological pathology

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