Gymnema sylvestre Leaf Extract: A 52-Week Dietary Toxicity Study in Wistar Rats

Antidiabetic properties of gymnema sylvestre (a review)

“…It was found that GS 4 stimulated hormone secretion in HIT-T15, MIN6, and RINm5F b-cell lines and in Langerhans islets in the absence of other stimuli regardless of the incubation temperature. The results confirmed that use of GS 4 increased insulin secretion, most probably due to an increased membrane permeability and not from stimulation of exocytosis by other pathways [25].…”

“…Intermediate hematological and biochemical blood parameters were measured after 26 weeks; final ones, after 52 weeks. No side effects were found upon administration of GS at doses of 504 -563 mg/kg/d in man [25].…”

“…The mechanism of the hypoglycemic action of GS is currently linked to the increase of insulin release from insulin-producing cells [25].…”

Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements

“…Gymnema Sylvestre has been used to control hyperglycemia [29] and hyperlipidemia [30] in rats. Toxicity studies in rodents have not shown hepatotoxicity [31] and no case report of liver injury has been reported. Rhodiola Rosea extract is used to decrease fatigue [32] and improve exercise tolerance [33] .…”

PHYTOCHEMICAL CONSTITUENTS AND HYPOGLYCEMIC EFFECT OF GYMNEMIC ACID EXTRACTS FROM BIG AND SMALL LEAF VARIETIES OF Gymnema Sylvestre R.Br

“…In addition, G. Sylvester leaf extract reduced high blood glucose in laboratory animals with potentials of treating diabetes in human and purified gymnemic acids are widely used as experimental reagents in taste physiology (Hellekant et al, 1998;Kanetkar et al, 2004). G. sylvestre has been reported to be safe in management of diabetes and short term uses of low doses may have unnoticeable side effects (Ogawa et al, 2004).…”