Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements

Dara, Lily; Hewett, Jennifer; Lim, Joseph K.

doi:10.3748/wjg.14.6999

Cited by 123 publications

(76 citation statements)

References 64 publications

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“…As a result, it is often not until these harmful effects are seen that a retrospective study elucidates these hazards. 12,13 For example, there are many components in Hydroxycut™ that are potentially hepatotoxic. Components of various Hydroxycut™ formulations for which hepatotoxicity have been described include Camellia sinensis and hydroxycitric acid.…”

Section: Discussionmentioning

confidence: 99%

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Liver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary Coproporphyria

et al. 2015

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We report the case of a young male presenting with cholestatic liver failure. After an extensive workup, the etiology of the liver failure was determined to be due to hereditary coprophorphyria (HCP). The inciting event was the use of Hydroxycut™, an over-the-counter supplement to promote weight loss that has been reported to cause oxidative liver injury in vulnerable populations. Although HCP is a rare cause of cholestatic liver failure, it is treatable if diagnosed correctly and in a timely manner. In this clinical vignette, we discuss a case that highlights the genetic susceptibility to disease that can be unmasked by environmental exposures. We also review the relevant literature on Hydroxycut™ and how it can affect hepatic function.KEY WORDS: porphyria; liver failure; herbal supplement use.

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Section: Discussionmentioning

confidence: 99%

“…Upon cessation of the drug, liver function improved within 7 weeks for most patients and often normalized by week 14. [12][13][14] In the case of our patient, Hydroxycut™ use was the cause of initial liver injury leading to fulminant failure in the setting of underlying porphyria.…”

Section: Discussionmentioning

confidence: 99%

Liver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary Coproporphyria

et al. 2015

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“…This substance was demonstrated to cause harmful cardiac and CNS effects [12], and subsequently banned by the FDA in April 2004 [13], although it is still reported to be available through online sources in different forms and mixtures. Hydroxycut, which is a popular weight loss supplement, has been reported to be associated with hepatotoxicity [14]. Chromium, another popular active ingredient, was linked with cases of acute hepatitis, thrombocytopenia and renal failure in a woman with chronic excessive use [15], and with rhabdomyolysis in two cases who used chromium as exercise aid [16,17].…”

Section: Discussionmentioning

confidence: 99%

Online weight loss supplement market and public health: An analysis of Turkish websites marketing weight loss supplements

Kaplan¹,

Demir²,

Karadaş³

et al. 2012

CMJ

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Aim. The Internet is becoming the primary tool of purchasing weight loss supplements since it is easily accessible to the consumers. When the uncontrollable nature of the Internet and the public's general tendency to use these supplements are considered together, the information conveyed to general audience in such websites become of great importance in the context of public health. This study aimed to analyze the quality and the quantity of the information conveyed to the consumers by Turkish websites marketing weight loss supplements. Method. This study was carried out between June and October, 2009. and a keyword search with the search query strings "weight loss drug" and "herbal weight loss" in Turkish conducted using Google to found websites of first 50 results of each search which were in Turkish and accessible to Turkish people and marketing these products Results. In majority of the websites, the information provided was found to be inadequate and misleading. Conclusion. Raising the public awareness and bringing restrictions of online marketing of these kinds of supplements are the urgent priorities to protect consumers from possible health risks.Keywords: Weight loss supplements, herbal weight loss, internet, online, marketing, safety, public health Özet Amaç. İnternet, zayıflatıcı gıda takviyelerinin temininde öncelikli bir araç haline gelmeye başlamıştır. İnternetin kontrol edilmesi güç yapısı ve halkın bu takviyelere olan ilgisi düşünüldüğünde, zayıflatıcı gıda takviyelerini pazarlayan web sitelerinden tüketiciye iletilen bilginin halk sağlığı açısından ne kadar önemli olduğu anlaşılacaktır. Bu çalışmada, zayıflatıcı gıda takviyelerini pazarlayan Türkçe içerikli internet sitelerindeki bilginin niceliksel ve niteliksel açıdan değerlendirilmesi amaçlanmıştır. Yöntem. Bu çalışma 2009 yılının Haziran ve Ekim ayları arasında Google arama motorunda Türkçe olarak "kilo kaybı ilaç" ve bitkisel kilo kaybı" sözcük dizinleri kullanarak Türk halkının erişebileceği bu ürünleri pazarlayan ilk 50 web sitesinin taranması ile gerçekleştirildi Bulgular. Genel olarak web sitelerinin çoğunluğunun içerdiği bilgilerin yetersiz ve yanıltıcı olduğu gözlenmiştir. Sonuç. Tüketicilerin bu tür takviyelerin neden olabileceği olası sağlık risklerinden korunması için atılması gereken acil ve öncelikli adımlar, tüketici farkındalığının arttırılması ve bu ürünlerin internet üzerinden pazarlanmasına getirilecek kısıtlamalardır.Anahtar sözcükler: Zayıflatıcı gıda takviyeleri, bitkisel ilaç ile zayıflama, internet, pazarlama, güvenlilik, halk sağlığı Geliş tarihi

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“…These products are often advertised to contain purely natural ingredients, hence assumed to be harmless. However, many such products have been reported to contain various illicit agents, including sibutramine, diethylpropion, phenolphthalein, fenfluramine, N-nitroso-fenfluramine, phentermine phenytoin, and even animal thyroid tissue posing a health risk on prolonged usage [1][2][3][4][5][6]. One study reported that the presence sibutramine and phenolphthalein resulted in high mortality and morbidity in Hong Kong population [4].…”

Section: Abstract: Slimming Products Sibutramine Phenolphthaleinmentioning

confidence: 99%

Detection of Illicit Substances in Slimming Products Available in UAE

Alabdooli¹,

Js²,

Chandrasekaran³

et al. 2017

Journal of Nutrition and Health Sciences

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Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements

Cited by 123 publications

References 64 publications

Liver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary Coproporphyria

Liver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary Coproporphyria

Online weight loss supplement market and public health: An analysis of Turkish websites marketing weight loss supplements

Detection of Illicit Substances in Slimming Products Available in UAE

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