Guttate leukoderma in Darier disease: case report and review

Clinicopathologic findings of guttate leukoderma in Darier disease: A helpful diagnostic feature

“…While the majority of cases have been reported in dark-skinned individuals of African descent, there have been cases reported in fair-skinned Japanese patients as well. 4 …”

“…Since the initial description, this manifestation has been sparsely reported and might be infrequently recognized as a diagnostic feature of this genodermatosis. 4 Herein, we report GL as a helpful identifying clinical finding in a case of previously unrecognized DD and, in addition, describe the histopathology of this dyschromia.…”

Familial case of darier disease with guttate leukoderma: A case series from India

“…Hypopigmented macules (guttate leukoderma or predominantly “idiopathic guttate hypomelanosis”) is known to be a rare finding in certain disorders of keratinization, e.g., DD, Grover disease, and Cole disease (guttate hypopigmentation with palmoplantar hyperkeratosis). [ 1 2 ] Here, we report 2 new cases of this association.…”

“…Guttate leukoderma or hypopigmented macules, as seen in two of our patients, has been reported primarily in high skin phototypes IV to VI and is considered a manifestation of DD in the dark-skinned, though it is considered to be a rare finding. It was first described by Goodall and Richmond in a patient of DD in 1965 (quoted in[ 1 ]). Terrom et al .…”

“…in a recent review on this association identified only 21 cases of DD with guttate leukoderma in the English- and French-language literature reported till now. [ 1 ] One case of DD associated with guttate leukoderma was reported by Sharma et al . from India in 2016.…”