Clinicopathologic findings of guttate leukoderma in Darier disease: A helpful diagnostic feature

Harb, Jennifer Nicole; Motaparthi, Kiran

doi:10.1016/j.jdcr.2017.09.021

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Lesions described in idiopathic confetti-like leukoderma and familial white lentiginosis are mainly truncal in distribution, with the latter being more prevalent in those of African descent 5, 6. Truncal guttate hypopigmetation in Darier disease is usually accompanied by other features, including greasy keratotic papules in seborrheic areas, acral keratoses, and V-shaped scalloping of the distal part of the nail 7 . Cole disease is characterized by palmoplantar hyperkeratotic papules and guttate hypopigmented macules affecting the trunk and extremities 8 .…”

Section: Discussionmentioning

confidence: 99%

Acral speckled hypomelanosis

Aldhalaan

Ghobara²,

Alisaa³

et al. 2019

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Acral speckled hypomelanosis

Aldhalaan

Ghobara²,

Alisaa³

et al. 2019

JAAD Case Reports

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“…Guttate leukoderma has been described as a rare manifestation of Darier's disease. [ 2 ] Dermoscopic features of greasy papules in Darier's have recently been described. [ 3 4 5 ] Brownish areas and fine white scales on dermoscopy correspond histopathologically to marked hyperkeratosis and parakeratosis while a peripheral whitish halo correlates with marked acanthosis.…”

mentioning

confidence: 99%

Darier's Disease with Guttate Leukoderma

Gupta

Mehta

Agarwal

et al. 2021

Indian Dermatology Online Journal

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Inherited Acantholytic Disorders

Zamiri

2024

Rook's Textbook of Dermatology

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Darier disease (DD) and Hailey–Hailey disease (HHD) are autosomal dominant disorders characterised by epidermal acantholysis. They have a similar molecular pathogenesis, with mutations in intracellular calcium pumps of the endoplasmic reticulum ( SERCA2 ) and Golgi ( SPCA1 ), respectively. DD presents with persistent, hyperkeratotic papules in a seborrhoeic distribution, associated with nail changes and palmar pitting. HHD presents with painful, mainly flexural, erosions. In both, secondary infection is common and hypertrophic flexural disease can be disabling. Histologically, both are characterised by loss of epidermal intercellular adhesion (acantholysis). DD may be accompanied by neuropsychiatric symptoms such as depression, epilepsy, learning disabilities or bipolar disease. First line topical treatment is with emollients, antimicrobials and corticosteroids. Oral antibiotics are often necessary for exacerbations; other systemic options include retinoids and ciclosporin. Physical measures such as laser resurfacing, photodynamic therapy, botulinum toxin and surgical interventions can be considered in refractory cases.

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Clinicopathologic findings of guttate leukoderma in Darier disease: A helpful diagnostic feature

Cited by 8 publications

References 9 publications

Acral speckled hypomelanosis

Acral speckled hypomelanosis

Darier's Disease with Guttate Leukoderma

Inherited Acantholytic Disorders

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