GUTI: a new antigen in the Cromer blood group system

Abstract

This study describes a novel high- incidence antigen (GUTI) in the Cromer blood group system characterized by the amino acid arginine at position 206 in SCR4 of DAF. The GUTI-negative proband has a substitution mutation that predicts for histidine at this position.

Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigens

“…Three new antigens of high incidence have been added: CROM11 (GUTI) [58], CROM12 (SERF) [59], and CROM13 (ZENA) [60] are associated with Arg206His, Pro182Leu and His208Gln in CD55, respectively.…”

International Society of Blood Transfusion Committee on terminology for red cell surface antigens: Vancouver Report

“…An antigen of very high incidence, named GUTI, has been given the number CROM11. The CROM:−11 phenotype is associated with a mutation encoding Arg206His in the CD55 glycoprotein [12].…”

Lack of the Cromer antigen GUTI in Mexican Americansand Choctaw Indians

“…No GUTI+ samples were found in our 122 samples comparedto 6 of 114 (5.3%) of the Mapuche Indians 3 . Althoughboth the Choctaw and the Mapuche are part of the Amerindian migrationfrom Asia, the Mapuche are considered to be an isolate especiallyfrom a linguistic point (M. Foster, personal communication).…”

“…By use of procedures similar to those reported by Storry andcolleagues, 3 we employed DAFSCR4Fand DAFSCR4R primers to amplify genomic DNA by PCR. The RFLP analysiswas performed on the amplified samples using the Tai I enzymefor digestion and a 2 percent agarose gel containing ethidium bromide.A known GUTI+ heterozygous DNA sample, provided by M. Reidat the New York Blood Center, was used as a positive control.…”