Gut-Skin Axis: Role in Health and Disease

Malaviya, Alok; Krishna, Kondapalli Vamsi; Malviya, Shruti; Das, T. Nimisha

doi:10.1007/978-981-16-5628-6_1

Cited by 2 publications

(4 citation statements)

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“…Among the significant microbial features identified by 16S rRNA gene analysis, increases in abundance of the genus Flavonifractor and a decrease of Faecalibacterium are of particular interest. F. prausnitzii is a well-known microbiomarker of inflammatory diseases, including Crohn's disease (59,60), irritable bowel syndrome (61), multiple sclerosis (44), rheumatic diseases (62), and even other inflammatory skin diseases, such as atopic dermatitis, psoriasis, and another autoimmune bullous disease, pemphigus (19,21,29). F. prausnitzii possesses antiinflammatory properties, which could contribute to its potential protective effects in inflammatory diseases (63).…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the skin microbiota, the role of gut microbiome in host skin health and disease is also gaining interest. Recent studies revealed intriguing links between gut microbiota and skin diseases (9,(19)(20)(21)(22). Firstly, some dermatoses pose as comorbidities of gastrointestinal disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, a recent study thoroughly characterized the alterations in the gut microbiota in pemphigus, another autoimmune bullous disease, whereby potentially pathogenic bacteria such as E. coli and Bacteroides fragilis were enriched in patients, while other anti-inflammatory and butyric acid-producing bacteria were significantly reduced (29). On the other hand, gut dysbiosis could increase host vulnerability and trigger an immunological response, resulting in skin imbalances (21,30). This intricate, bidirectional link known as the "gut-skin axis", is also thought to involve microbial metabolites such as short chain fatty acids (SCFAs) and gamma-aminobutyric acid (GABA), with SCFAs enhancing epithelial barrier function and GABA inhibiting itch-signaling (30).…”

Section: Introductionmentioning

confidence: 99%

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The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility

Liu,

van Beek,

Cepic

et al. 2023

Front. Immunol.

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Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects the elderly. An altered skin microbiota in BP was recently revealed. Accumulating evidence points toward a link between the gut microbiota and skin diseases; however, the gut microbiota composition of BP patients remains largely underexplored, with only one pilot study to date, with a very limited sample size and no functional profiling of gut microbiota. To thoroughly investigate the composition and function of the gut microbiota in BP patients, and explore possible links between skin conditions and gut microbiota, we here investigated the gut microbiota of 66 patients (81.8% firstly diagnosed) suffering from BP and 66 age-, sex-, and study center-matched controls (CL) with non-inflammatory skin diseases (132 total participants), using 16S rRNA gene and shotgun sequencing data. Decreased alpha-diversity and an overall altered gut microbial community is observed in BP patients. Similar trends are observed in subclassifications of BP patients, including first diagnoses and relapsed cases. Furthermore, we observe a set of BP disease-associated gut microbial features, including reduced Faecalibacterium prausnitzii and greater abundance of pathways related to gamma-aminobutyric acid (GABA) metabolism in BP patients. Interestingly, F. prausnitzii is a well-known microbiomarker of inflammatory diseases, which has been reported to be reduced in the gut microbiome of atopic dermatitis and psoriasis patients. Moreover, GABA plays multiple roles in maintaining skin health, including the inhibition of itching by acting as a neurotransmitter, attenuating skin lesions by balancing Th1 and Th2 levels, and maintaining skin elasticity by increasing the expression of type I collagen. These findings thus suggest that gut microbiota alterations present in BP may play a role in the disease, and certain key microbes and functions may contribute to the link between gut dysbiosis and BP disease activity. Further studies to investigate the underlying mechanisms of the gut-skin interaction are thus clearly warranted, which could aid in the development of potential therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility

Liu,

van Beek,

Cepic

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Apart from their topical uses, gut probiotic bacteria have the ability to influence wound healing by inducing systemic immunity, increasing nutritional absorption, and modulating the gut–brain–skin axis. 97 Researchers have begun to establish connections between the gut microbiota, skin health, and the immune system. Probiotics taken orally may elicit both a local and a systemic immune response.…”

Section: Cutaneous Health Through the Gut–brain–skin Axesmentioning

confidence: 99%