Gut modulatory and antiplatelet activities ofViscum cruciatum

Comparative studies on the effect of environmental pollution on secondary metabolite contents and genotoxicity of two plants in Asir area, Saudi Arabia

“…The essential oil of S. molle contains αphellandrene, limonene, β-phellandrene, elemol and α-eudesmol, and it possesses antibacterial activity [9]. In traditional medicine, S. molle has been used for treating a variety of wounds and infections due to its antibacterial and antiseptic properties [10].…”

Pharmacological studies onHypericum perforatumfractions and constituents

“…When tested in isolated jejunum, the chloroform, ethyl acetate and aqueous fractions of Hypericum perforatum inhibited both spontaneous and high K + -induced contractions with similar potency. Papaverine, a PDE and Ca 2+ influx inhibitor (Kaneda et al, 2005), caused similar pattern of inhibitory effect with comparable potency against spontaneous and K + -induced contractions, while petroleum spirit fraction, like verapamil, a standard Ca 2+ antagonist (Gilani et al, 2009) was relatively selective in its inhibitory effect on the K + -induced contractions, a typical characteristic of Ca 2+ entry blockers (Gilani et al, 2005b). The ethyl acetate fraction was found to be the most potent, being 20-, 12-and 35-times more potent for its antispasmodic effect than the petroleum spirit, chloroform and aqueous fraction, respectively.…”

Bronchodilator Activity of Aerial Parts of Polygonatum verticillatum Augmented by Anti‐inflammatory Activity: Attenuation of Ca2+ Channels and Lipoxygenase

“…At high concentration (>30 mM), K + is known to cause smooth muscle contractions through opening of VDCs, consequently allowing inward movement of extracellular Ca 2+ originating a contractile effect and a substance causing inhibition of high K + ‐induced contraction is considered as an inhibitor of Ca 2+ influx. Verapamil, a standard Ca 2+ channel blocker (Gilani et al ., ), also produced non‐specific inhibition of spontaneous and K + ‐induced contractions. The presence of Ca 2+ antagonist constituent(s) was further strengthened when the PA caused a rightward shift in the Ca 2+ CRCs (constructed in the applied K + ‐rich and Ca 2+ ‐free medium) and suppressed the maximal response similar to that caused by verapamil.…”