Gut microbiota profile of patients on peritoneal dialysis: comparison with household contacts

Teixeira, Renata Rodrigues; Andrade, Laila Santos de; Pereira, Natalia Barros Ferreira; Montenegro, Horácio; Hoffmann, Christian; Cuppari, Lílian

doi:10.1038/s41430-022-01190-7

Cited by 5 publications

(3 citation statements)

References 52 publications

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“…As a peritoneal cavity-dependent treatment, PD is closely related to peritoneal function and the gut microbiome. Currently, the gut microbiome in patients undergoing PD is believed to be unbalanced [ 30 ]; however, the gut microbiome between patients undergoing PD and their household contacts are not significantly different [ 31 ]. Our study further confirmed the differences in gut microbiome abundance and structure between patients undergoing PD and those with non-dialysis ESRD.…”

Section: Discussionmentioning

confidence: 99%

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Wang,

Wu,

Zhang

et al. 2023

BMC Nephrol

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Background Growing evidence has demonstrated that patients undergoing peritoneal dialysis (PD) are more likely to experience cognitive impairment than patients with non-dialysis end-stage renal disease (ESRD); however, the underlying mechanisms remain unclear. This study aimed to identify the role and predictive significance of gut microbiome alterations in PD-associated cognitive impairment. Methods A total of 29 non-dialysis ESRD patients and 28 PD patients were enrolled in this study and divided into subgroups according to the Montreal Cognitive Assessment (MoCA). Faecal samples were analyzed using 16 S rRNA. Mini-Mental State Examination (MMSE) and MoCA scores were used to assess the degree of cognitive impairment in patients. Results The 16 S rRNA analysis demonstrated differences in gut microbiome abundance and structure between PD and non-dialysis ESRD patients and between PD patients with cognitive impairment (PCI) and PD patients with normal cognition (PNCI). At family and genus levels, Prevotellaceae exhibited the greatest structure difference, while Lactobacillus exhibited the greatest abundance difference between PCI and PNCI. Altered microbiota abundance significantly correlated with cognitive function and serum indicators in PD. In addition, different modules related to fatty acid, lipid, pantothenate, and coenzyme A biosynthesis, and tyrosine and tryptophan metabolism were inferred from 16 S rRNA data between PCI and PNCI. Both groups could be distinguished using models based on the abundance of Lactobacillaceae (Area under curve [AUC] = 0.83), Actinomycetaceae (AUC = 0.798), and Prevotellaceae (AUC = 0.778) families and Lactobacillus (AUC = 0.848) and Actinomyces (AUC = 0.798) genera. Conclusion Gut microbiome evaluation could aid early cognitive impairment diagnosis in patients undergoing PD.

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Section: Discussionmentioning

confidence: 99%

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Wang,

Wu,

Zhang

et al. 2023

BMC Nephrol

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“… 48 However, other researchers found no bacterial differences between patients receiving PD and non–dialysis-dependent patients with CKD 49 and household contacts. 50 These conflicting results could arise from different research methodologies and dialysis-related or patient related factors, such as differing PD modalities, PD solution compositions, glucose absorptions, peritonitis histories, comorbidities, protein intakes and dietary restrictions, or antibiotic and other medication uses that could affect the gut microbiota composition.…”

Section: Gut Microbiota In Patients Treated With Pd and Its Associati...mentioning

confidence: 99%

The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis

Stepanova¹

2023

Kidney Medicine

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“…Thus, the combination of increased SNS to the gut and dampened vagal afferent parasympathetic nervous system (PNS) drive from the gut to the brain cardioregulatory regions, such as the nucleus of the solitary tract, contributes to hypertension development. Studies evaluating specific changes in the gut microbiota in PD patients are more inconsistent than those focused on the general cohort of patients with CKD [32][33][34][35]. These conflicting results have been attributed to different research methodologies and dialysis-related or patientrelated factors (differing PD modalities, PD solution compositions, peritonitis histories, comorbidities, medication, etc.)…”

Section: Pathophysiology Of Ans Dysfunction In Eskdmentioning

confidence: 99%

Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

Faitatzidou,

Karagiannidis,

Theodorakopoulou

et al. 2023

Am J Nephrol

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Background: In patients with end-stage kidney disease (ESKD) receiving peritoneal dialysis (PD) cardiovascular events represent the predominant cause of morbidity and mortality, with cardiac arrhythmias and sudden death being the leading causes of death in this population. Autonomic nervous system (ANS) dysfunction is listed among the non-traditional risk factors accounting for the observed high cardiovascular burden, with a plethora of complex and not yet fully understood pathophysiologic mechanisms being involved. Summary: In recent years, preliminary studies have investigated and confirmed the presence of ANS dysfunction in PD patients, while relevant results from cohort studies have linked ANS dysfunction with adverse clinical outcomes in these patients. In light of these findings, ANS dysfunction has been recently receiving wider consideration as an independent cardiovascular risk factor in PD patients. The aim of this review is to describe the mechanisms involved in the pathogenesis of ANS dysfunction in ESKD and particularly PD patients and to summarize the existing studies evaluating ANS dysfunction in PD patients. Key messages: ANS dysfunction in PD patients is related to multiple complex mechanisms that impair the balance between SNS/PNS and this disruption represents a crucial intermediator of cardiovascular morbidity and mortality in this population.

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Gut microbiota profile of patients on peritoneal dialysis: comparison with household contacts

Cited by 5 publications

References 52 publications

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis

Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

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