The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis

Stepanova, N.

doi:10.1016/j.xkme.2023.100645

Cited by 6 publications

(2 citation statements)

References 88 publications

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“…Instead, it is influenced by the individualized dialysis prescription and the clinical characteristics of each PD patient. Additionally, studies have established correlations between the gut microbiota composition and factors such as the duration of dialysis treatment (dialysis vintage), the level of residual kidney function, and the extent of peritoneal glucose exposure in PD patients ( Stepanova, 2023 ). Prolonged dialysis sessions, elevated peritoneal glucose exposure, and the decline in residual renal function have been linked to changes in gut microbial composition and a decrease in the production of branched-chain short-chain fatty acids among PD patients.…”

Section: Inter-organ Communicationmentioning

confidence: 99%

Intercellular communication in peritoneal dialysis

Sheng,

Shan,

Dai

et al. 2024

Front. Physiol.

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Long-term peritoneal dialysis (PD) causes structural and functional alterations of the peritoneal membrane. Peritoneal deterioration and fibrosis are multicellular and multimolecular processes. Under stimulation by deleterious factors such as non-biocompatibility of PD solution, various cells in the abdominal cavity show differing characteristics, such as the secretion of different cytokines, varying protein expression levels, and transdifferentiation into other cells. In this review, we discuss the role of various cells in the abdominal cavity and their interactions in the pathogenesis of PD. An in-depth understanding of intercellular communication and inter-organ communication in PD will lead to a better understanding of the pathogenesis of this disease, enabling the development of novel therapeutic targets.

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Section: Inter-organ Communicationmentioning

confidence: 99%

Intercellular communication in peritoneal dialysis

Sheng,

Shan,

Dai

et al. 2024

Front. Physiol.

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“…Besides miR-15a-5p, peritoneal fibrosis is also modulated by miR-199a-5p, miR-214-3p, miR-30a, miR-153-3p, miR-21, miR-129-5p, miR-30b, miR-200, miR-145, miR-302c, miR-34a, and miR-29b [ 25 , 26 ]. Recently, the potential link between the intestinal microbiota and dysbiosis with peritoneal fibrosis has been discussed, in which several molecular and cellular mechanisms are likely to contribute to the formation of peritoneal fibrosis, for example, gut-sourced metabolites (e.g., short-chain fatty acids (SCFA) and lipopolysaccharides (LPS)), inflammation, production of reactive oxygen species and oxidative stress, activation of the host immune response, and intestinal bacterial translocation [ 27 ].…”

Section: The Pathophysiology Of Peritoneal Fibrosismentioning

confidence: 99%

Current Insights into Cellular Determinants of Peritoneal Fibrosis in Peritoneal Dialysis: A Narrative Review

Suryantoro

Wungu

Sutanto

et al. 2023

JCM

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Peritoneal fibrosis is the final process of progressive changes in the peritoneal membrane due to chronic inflammation and infection. It is one of the main causes of discontinuation of peritoneal dialysis (PD), apart from peritonitis and cardiovascular complications. Over time, morphological changes occur in the peritoneal membranes of patients who use PD. Of those are mesothelial-to-mesenchymal transition (MMT), neoangiogenesis, sub-mesothelial fibrosis, and hyalinizing vasculopathy. Several key molecules are involved in the complex pathophysiology of peritoneal fibrosis, including advanced glycosylation end products (AGEs), transforming growth factor beta (TGF-β), and vascular endothelial growth factor (VEGF). This narrative review will first discuss the physiology of the peritoneum and PD. Next, the multifaceted pathophysiology of peritoneal fibrosis, including the effects of hyperglycemia and diabetes mellitus on the peritoneal membrane, and the promising biomarkers of peritoneal fibrosis will be reviewed. Finally, the current and future management of peritoneal fibrosis will be discussed, including the potential benefits of new-generation glucose-lowering medications to prevent or slow down the progression of peritoneal fibrosis.

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Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

Faitatzidou,

Karagiannidis,

Theodorakopoulou

et al. 2023

Am J Nephrol

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Background: In patients with end-stage kidney disease (ESKD) receiving peritoneal dialysis (PD) cardiovascular events represent the predominant cause of morbidity and mortality, with cardiac arrhythmias and sudden death being the leading causes of death in this population. Autonomic nervous system (ANS) dysfunction is listed among the non-traditional risk factors accounting for the observed high cardiovascular burden, with a plethora of complex and not yet fully understood pathophysiologic mechanisms being involved. Summary: In recent years, preliminary studies have investigated and confirmed the presence of ANS dysfunction in PD patients, while relevant results from cohort studies have linked ANS dysfunction with adverse clinical outcomes in these patients. In light of these findings, ANS dysfunction has been recently receiving wider consideration as an independent cardiovascular risk factor in PD patients. The aim of this review is to describe the mechanisms involved in the pathogenesis of ANS dysfunction in ESKD and particularly PD patients and to summarize the existing studies evaluating ANS dysfunction in PD patients. Key messages: ANS dysfunction in PD patients is related to multiple complex mechanisms that impair the balance between SNS/PNS and this disruption represents a crucial intermediator of cardiovascular morbidity and mortality in this population.

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The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis

Cited by 6 publications

References 88 publications

Intercellular communication in peritoneal dialysis

Intercellular communication in peritoneal dialysis

Current Insights into Cellular Determinants of Peritoneal Fibrosis in Peritoneal Dialysis: A Narrative Review

Autonomic Nervous System Dysfunction in Peritoneal Dialysis Patients: An Underrecognized Cardiovascular Risk Factor?

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