Gut microbiota of the very-low-birth-weight infant

Unger, Sharon; Stintzi, Alain; Shah, Prakeshkumar S; Mack, David R.; O'Connor, Deborah L

doi:10.1038/pr.2014.162

Cited by 91 publications

(114 citation statements)

References 79 publications

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“…Even though vertical transmission in mammals is not as explicit as in plants (none are transferred with the germline), vertical transmission nevertheless occurs. The transmission from parent to offspring results from the birth process itself, from milk, and from the close contact that comes from parental care (Unger et al, 2015). In humans, vaginal birth inoculates the newborn with a set of strains that can be matched to the mother, whereas caesarean section results in colonization with skin microbes originating from various caregivers (Dominguez-Bello et al, 2010).…”

Section: Community Structure Of the Vertebrate Gut And Plant Root Micmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

594

470

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Plants and animals each have evolved specialized organs dedicated to nutrient acquisition, and these harbor specific bacterial communities that extend the host's metabolic repertoire. Similar forces driving microbial community establishment in the gut and plant roots include diet/soil-type, host genotype, and immune system as well as microbe-microbe interactions. Here we show that there is no overlap of abundant bacterial taxa between the microbiotas of the mammalian gut and plant roots, whereas taxa overlap does exist between fish gut and plant root communities. A comparison of root and gut microbiota composition in multiple host species belonging to the same evolutionary lineage reveals host phylogenetic signals in both eukaryotic kingdoms. The reasons underlying striking differences in microbiota composition in independently evolved, yet functionally related, organs in plants and animals remain unclear but might include differences in start inoculum and niche-specific factors such as oxygen levels, temperature, pH, and organic carbon availability.

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Section: Community Structure Of the Vertebrate Gut And Plant Root Micmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

594

470

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“…Because the risk of LOS is higher in infants born at <32 weeks or <1500 g, 3,4 we conducted sensitivity analysis by excluding RCTs where the inclusion criteria were ≥32 weeks or ≥1500 g. Similar analyses were also conducted for studies where Bifidobacterium was or was not part of the supplement and studies where Lactobacillus was or was not part of the supplement, given the importance of these microorganisms in the neonatal gut flora. 41 There is some evidence that multistrain probiotics may be more effective than single strains. 42 We therefore conducted analyses separately for studies that used single-strain supplements and multistrain probiotics.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis

et al. 2016

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CONTEXT: Late-onset sepsis (LOS) is a major cause of mortality and morbidity in preterm infants. Despite various preventive measures, its incidence continues to remain high, hence the urgent need for additional approaches. One such potential strategy is supplementation with probiotics. The updated Cochrane Review (2014) did not find benefits of probiotics in reducing the risk of LOS in preterm infants (19 studies, N = 5338). Currently there are >30 randomized controlled trials (RCTs) of probiotics in preterm infants that have reported on LOS. OBJECTIVES:To conduct a systematic review including all relevant RCTs.DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, and E-abstracts from the Pediatric Academic Society meetings and other pediatric and neonatal conference proceedings were searched in June and August 2015.STUDY SELECTION: RCTs comparing probiotics versus placebo/no probiotic were included. DATA EXTRACTION:Relevant data were extracted independently by 3 reviewers. RESULTS:Pooled results from 37 RCTs (N = 9416) using fixed effects model meta analysis showed that probiotics significantly decreased the risk of LOS (675/4852 [13.9%] vs 744/4564 [16.3%]; relative risk, 0.86; 95% confidence interval, 0.78-0.94; P = .0007; I 2 = 35%; number needed to treat, 44). The results were significant even after excluding studies with high risk of bias. CONCLUSIONS: Probiotic supplementation reduces the risk of LOS in preterm infants.a Neonatal ICU, King Edward Memorial Hospital for Women, Perth, Western Australia; b Neonatal ICU, Princess Margaret Hospital for Children, Perth, Western Australia; c Centre for Neonatal Research and Education, School of Pediatrics and Child Health, University of Western Australia, Perth, Western Australia; d Neonatal ICU, Nepean Hospital, Kingswood, NSW, Australia; and e Sydney Medical School, Nepean, University of Sydney, Australia Dr Rao conceptualized and designed the study, performed an independent literature search, selected studies for inclusion, extracted and interpreted data, assessed risk of bias of included studies, handled the meta-analysis software, and wrote the fi rst and fi nal drafts of the manuscript; Dr Athalye-Jape performed an independent literature search, selected studies for inclusion, contacted authors for additional information where necessary, extracted and interpreted the data, checked the data entered by S.C.R. on the meta-analysis software, assessed the risk of bias of included studies, and helped with the fi rst and the fi nal draft of the manuscript; Dr Deshpande performed an independent literature search, selected studies for inclusion, verifi ed the extracted data, assessed risk of bias, interpreted data, and oversaw translation of manuscripts in the Chinese language; Dr Simmer supervised the project, interpreted the data, and supervised the fi rst and fi nal versions of the manuscript; Dr Patole supervised the project, acted as referee author in case of d...

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“…Hal tersebut disebabkan karena ibu bayi masih dirawat di ruang intensif dan penolakan orang tua untuk pemberian ASI donor yang berhubungan dengan keyakinan dan budaya. Hasil penelitian yang dilakukan oleh Unger et al (2015) menyatakan bahwa pemberian kolostrum ibu pada minggu pertama kehidupan BBLR akan berefek pada maturasi saluran gastrointestinal. Pemberian ASI pada BBLR dua kali lipat lebih cepat diabsorbsi dibandingkan dengan susu formula, sehingga dapat menurunkan kejadian intoleransi pemberian minum enteral (Underwood, 2013).…”

Section: Pembahasanunclassified

Sleep Positioning in Low Birth Weight Infants to Reduce Enteral Feeding Intolerance

Astuti¹,

Rustina

Waluyanti

2018

Nurscope

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AbstrakPendahuluan: Intoleransi pemberian minum enteral merupakan masalah yang sering terjadi pada bayi berat lahir rendah. Penelitian bertujuan untuk menganalisis pengaruh pengaturan posisi tidur pada bayi berat lahir rendah terhadap kejadian intoleransi pemberian minum enteral. Metodologi: Desain penelitian adalah kuasi eksperimen pada 20 bayi berat lahir rendah dengan teknik purposive sampling. Bayi dikelompokkan menjadi kelompok intervensi dan kontrol. Bayi pada kelompok kontrol dilakukan intervensi sesuai standar prosedur rutin; sedangkan pada kelompok intervensi dilakukan pengaturan posisi tidur pronasi setelah pemberian minum enteral dan meninggikan bagian kepala tempat tidur 30 derajat selama pemberian minum enteral. Hasil: Analisis uji t independen dan Fisher's Exact Test menunjukkan bahwa pengaturan posisi tidur dapat menurunkan kejadian desaturasi (p value = 0,011), distensi abdomen (p value = 0,017), dan frekuensi muntah (p value = 0,035). Diskusi: Perawat dapat menjadikan intervensi pengaturan posisi tidur sebagai standar prosedur operasional pada bayi berat lahir rendah yang mengalami intoleransi pemberian minum enteral. Kata kunci: bayi berat lahir rendah, intoleransi pemberian minum enteral, pengaturan posisi tidur Sleep Positioning in Low Birth Weight Infants to Reduce Enteral Feeding Intolerance Abstract Introduction: Enteral feeding intolerance is a common problem in low birth weight infants. This study aimed to analyze the effects of sleep positioning on low birth weight infants on the occurrence of enteral feeding intolerance. Methodology: This quasi experiment was applied on 20 low birth weight infants with a purposive sampling technique. The infants were grouped into control and intervention. Infants in the control

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Gut microbiota of the very-low-birth-weight infant

Cited by 91 publications

References 79 publications

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Probiotic Supplementation and Late-Onset Sepsis in Preterm Infants: A Meta-analysis

Sleep Positioning in Low Birth Weight Infants to Reduce Enteral Feeding Intolerance

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