Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil

Melli, Lígia Cristina Fonseca Lahoz; Carmo-Rodrigues, Mirian Silva; Araújo-Filho, Humberto Bezerra; Mello, Carolina Santos; Tahan, Soraia; Pignatari, Antônio Carlos Campos; Solé, Dírceu; Morais, Mauro Batista de

doi:10.1016/j.aller.2019.08.004

Cited by 22 publications

(23 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have reported that the intestinal microbial colonization pattern differs between non-allergic and allergic infants, with the latter group harboring a lower abundance of Bifidobacterium [126,127]. Later on, during childhood, the information is more controversial since some authors evidenced higher levels of the genus Bifidobacterium in allergic infants than in healthy children [128,129]. Lower diversity within the genus Bifidobacterium has been found in fecal samples of infants suffering cow's milk protein allergy [130].…”

Section: Maturation Of the Immune System: Early Bifidobacterial Alterations Leading To Atopymentioning

confidence: 99%

Role of Bifidobacteria on Infant Health

et al. 2021

View full text Add to dashboard Cite

Bifidobacteria are among the predominant microorganisms during infancy, being a dominant microbial group in the healthy breastfed infant and playing a crucial role in newborns and infant development. Not only the levels of the Bifidobacterium genus but also the profile and quantity of the different bifidobacterial species have been demonstrated to be of relevance to infant health. Although no definitive proof is available on the causal association, reduced levels of bifidobacteria are perhaps the most frequently observed alteration of the intestinal microbiota in infant diseases. Moreover, Bifidobacterium strains have been extensively studied by their probiotic attributes. This review compiles the available information about bifidobacterial composition and function since the beginning of life, describing different perinatal factors affecting them, and their implications on different health alterations in infancy. In addition, this review gathers exhaustive information about pre-clinical and clinical studies with Bifidobacterium strains as probiotics in neonates.

show abstract

Section: Maturation Of the Immune System: Early Bifidobacterial Alterations Leading To Atopymentioning

confidence: 99%

Role of Bifidobacteria on Infant Health

et al. 2021

View full text Add to dashboard Cite

show abstract

“…AD patients display poor gut microbial diversity in several clinical trials [130][131][132][133][134][135][136][137][138], while contradictory results exist [139][140][141][142]. Similarly, to the skin, AD patients exhibit abundant S. aureus in their gut microbiota [143][144][145][146]. Other microbes associated with inflammation and epithelial damage, such as Clostridiodes difficile, and coliforms, including pathogenic Escherichia coli, are increased in the gut microbiota of AD patients [136,140,[146][147][148][149][150][151][152].…”

Section: The Gut Microbiota Profiles In Ad Patientsmentioning

confidence: 99%

Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies

et al. 2022

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Numerous studies have highlighted the involvement of the skin and gut microbiota in the pathogenesis of AD. The resident microbiota at these two epithelial tissues can modulate skin barrier functions and host immune responses, thus regulating AD progression. For example, the pathogenic roles of Staphylococcus aureus in the skin are well-established, making this bacterium an attractive target for AD treatment. Targeting the gut microbiota is another therapeutic strategy for AD. Multiple oral supplements with prebiotics, probiotics, postbiotics, and synbiotics have demonstrated promising efficacy in both AD prevention and treatment. In this review, we summarize the association of microbiota dysbiosis in both the skin and gut with AD, and the current knowledge of the functions of commensal microbiota in AD pathogenesis. Furthermore, we discuss the existing therapies in manipulating both the skin and gut commensal microbiota to prevent or treat AD. We also propose potential novel therapies based on the cutting-edge progress in this area.

show abstract

“…In recent years, with the development of high-throughput technology, the relationship between the human micro-ecosystem and AD has been gradually revealed. Some studies [ 10 , 11 ] speculate that intestinal microbiota disturbance may be related to the pathogenesis and severity of AD. Previous studies [ 12 , 13 ] have pointed out that the composition of the gut microbiota is significantly different between healthy children and children with allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota and atopic dermatitis in children: a scoping review

Liu¹,

Zhai³

et al. 2022

BMC Pediatr

View full text Add to dashboard Cite

Background Gut microbiota plays an important role in the development of atopic dermatitis (AD). We aimed to elucidate research trends in gut microbiota and AD in children, to provide evidence and insights to the clinical prevention and treatment of AD in children. Methods A scoping literature review on the studies of gut microbiota and AD were conducted. Two authors independently searched Pubmed et al. databases for studies focused on gut microbiota and AD in children up to January 15, 2022. The literatures were screened and analyzed by two reviewers. Results A total of 44 reports were finally included and analyzed. Current researches have indicated that abnormal human microecology is closely associated with AD, and the disturbance of intestinal microbiota plays an important role in the occurrence and development of AD. Probiotics can correct the microbiota disorder, have the functions of regulating immunity, antioxidant, and help to restore the microecological homeostasis. However, there is still a lack of high-quality research reports on the efficacy and safety of probiotics in the prevention and treatment of AD in children. Conclusions The changes of gut microbiota are essential to the development of AD in children, which may be an effective target for the prevention and treatment of AD. Future studies with larger sample size and rigorous design are needed to elucidate the effects and safety of probiotics in AD.

show abstract

Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil

Cited by 22 publications

References 34 publications

Role of Bifidobacteria on Infant Health

Role of Bifidobacteria on Infant Health

Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies

Gut microbiota and atopic dermatitis in children: a scoping review

Contact Info

Product

Resources

About