Gut microbiota of adults with different metabolic phenotypes

Olivares, Priscila dos Santos Gomes; Aranha, Luciana Nicolau; Oliveira, Bianca da Silva; Santos, Allan Amorim; Santos, Paula Cristina Moreira dos; Neto, José Firmino Nogueira; Rosa, Glorimar; Oliveira, Gláucia Maria Moraes de

doi:10.1016/j.nut.2021.111293

Cited by 20 publications

(15 citation statements)

References 41 publications

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“…As such, hyperuricemia has been considered a component of metabolic syndrome (2). Previous studies have shown that a high relative abundance of genus Coprococcus is associated with a low prevalence of metabolic diseases, such as type 2 diabetes, hyperlipemia, and obesity (36–38). Findings from our 2 independent study samples are consistent with previous reports, suggesting that a low relative abundance of genus Coprococcus may play a role in hyperuricemia.…”

Section: Discussionmentioning

confidence: 99%

Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts

Wei

Zhang

Dalbeth

et al. 2022

Arthritis & Rheumatology

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Objective Hyperuricemia is a precursor to gout and is often present in other metabolic diseases that are promoted by microbiome dysbiosis. We undertook this study to examine the association of gut microbiota with hyperuricemia and serum urate levels in humans. Methods Study participants were derived from a community‐based observational study, the Xiangya Osteoarthritis Study (discovery cohort). Hyperuricemia was defined as the presence of a serum urate level >357 μmoles/liter in women and >416 μmoles/liter in men. Gut microbiota were analyzed using 16S ribosomal RNA sequencing of stool samples. We examined the relationship of microbiota dysbiosis (i.e., richness, diversity, composition, and relative abundance of microbiota taxa) and predicted functional pathways to prevalent hyperuricemia and serum urate levels. We verified the associations in an independent observational study, the Step Study (validation cohort). Results The discovery cohort consisted of 1,392 subjects from rural areas (mean age 61.3 years, 57.4% women, 17.2% with hyperuricemia). Participants with hyperuricemia had decreased richness and diversity, altered composition of microbiota, and lower relative abundances of genus Coprococcus compared to those with normouricemia. Predicted KEGG metabolism pathways including amino acid and nucleotide metabolisms were significantly altered in subjects with hyperuricemia compared to those with normouricemia. Gut microbiota richness, diversity, and low relative abundances of genus Coprococcus were also associated with high levels of serum urate. These findings were replicated in the validation cohort with 480 participants. Conclusion Gut microbiota dysbiosis is associated with elevated serum urate levels. Our study examines the possibility that microbiota dysbiosis may modulate these levels.

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Section: Discussionmentioning

confidence: 99%

Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts

Wei

Zhang

Dalbeth

et al. 2022

Arthritis & Rheumatology

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“…Thus, Olivares et al observed differences in gut microbiome of adults depending on weight status, finding a rise in the genus Bifidobacterium and a decrease in Prevotellaceae, Faecalibacterium, and Eubacteriumrectale in participants with normal weight compared to those who had overweight or obesity. 29 In addition, the phylum Bacteroidetes 24,25,28,30 and the genus Bifidobacterium 27 are underrepresented in gut microbiota of children with overweight or obesity compared to the microbiota of children with normal-weight (Table 1), where lifestyle changes (diet/physical activity) may affect fecal microbiota. 30 In this context, a multicenter prospective cohort trial called TEDDY study was designed, with the objective of identifying those environmental factors that triggered or protected against type 1 diabetes.…”

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confidence: 99%

Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

et al. 2021

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Summary Childhood obesity is a costly burden in most regions with relevant and adverse long‐term health consequences in adult life. Several studies have associated excessive body weight with a specific profile of gut microbiota. Different factors related to fecal microorganism abundance seem to contribute to childhood obesity, such as gestational weight gain, perinatal diet, antibiotic administration to the mother and/or child, birth delivery, and feeding patterns, among others. This review reports and discusses diverse factors that affect the infant intestinal microbiota with putative or possible implications on the increase of the obesity childhood rates as well as microbiota shifts associated with excessive body weight in children.

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“…A total of ten cohorts from nine BioProjects were included, four for childhood obesity (PRJNA647465 12 , PRJNA317290, PRJNA433269 13 , PRJNA637782 14 ) and five for adulthood obesity (PRJNA483803, PRJNA339677 15 , PRJNA631293 16 , PRJNA273824, PRJNA417691 17 ). Among these projects, 601 samples of raw data met our categories and were further analyzed, and the detail of each BioProject is shown in supplementary tables.…”

Section: Resultsmentioning

confidence: 99%

Greater alteration of gut microbiota occurs in childhood obesity than adulthood obesity

Zhu

Zhao

et al. 2022

Preprint

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The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the difference in gut microbiota between obese children and adults, we collected and re-analyzed published data from National Center for Biotechnology Information (NCBI). We found that the gut microbiota had a significant difference between children with and without obesity, but this did not happen in adults. Based on the random forest model, childhood obesity is more challenging to predict using gut microbiota than adulthood obesity. Our results suggest that gut microbiota in childhood is more easily affected than in adulthood. Hence, early intervention for childhood obesity is essential to improve children's health and lifelong gut microbiota-related health.

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Gut microbiota of adults with different metabolic phenotypes

Cited by 20 publications

References 41 publications

Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts

Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts

Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

Greater alteration of gut microbiota occurs in childhood obesity than adulthood obesity

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