Gut Microbiota Modulation and Anti-Inflammatory Properties of Dietary Polyphenols in IBD: New and Consolidated Perspectives

Santino, Angelo; Scarano, Aurelia; Santis, Stefania De; Benedictis, Maria De; Giovinazzo, Giovanna; Chieppa, Marcello

doi:10.2174/1381612823666170207145420

Cited by 50 publications

(35 citation statements)

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“…In healthy individuals, the mucosal immune system is dynamically educated towards tolerance to luminal antigens, including commensal bacteria and food derived antigens [ 35 ]. Several factors contribute to DCs’ “maturation” [ 23 , 24 ], including food-derived products [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

et al. 2017

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Dendritic cells’ (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract.

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Section: Resultsmentioning

confidence: 99%

Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

et al. 2017

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“…On these bases, their consumption might have positive effects on human health. Other studies indicate that diets rich in anthocyanins and phenolic acids have protective effects against oxidative stress, involved in the onset of aging processes and several human pathologies [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…In plants, anthocyanins are synthetized by the flavonoid biosynthetic pathway, which leads also to the production of phenolic acids and other classes of polyphenols with healthy benefits [20][21][22]. In this study, we carried out the chemical profiling of antioxidant compounds and characterized the main classes of polyphenols, carotenoids, sugars, and organic acids, which can contribute to the quality and nutritional value of Tiggiano carrots and to the valorization of this local landrace.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

et al. 2018

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Abstract:The carrot (Daucus carota L.) is an important vegetable source of bioactive compounds in the human diet. In the Apulia region (Southern Italy), local farmers have domesticated colored landraces of carrots over the years, strictly related to local cults and traditions. Amongst these, an important landrace is the carrot of Saint Ippazio or the Tiggiano carrot. In the present study, we evaluated the content of carotenoids, anthocyanins, phenolic acids, sugars, organic acids, and antioxidant activity in Tiggiano carrots. Our results indicated that yellow-purple carrots have the highest levels of bioactive compounds, together with the highest antioxidant capacity compared to the yellow and cultivated orange varieties. These data point out the nutritional value of purple Tiggiano carrots and may contribute to the valorization of this typical landrace.

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“…Canarium album is a type of polyphenol-rich fruit with a total phenolic content of 1174.0–1799.6 mg gallic acid equivalents/100 g fresh weight [ 11 ]. Its high polyphenol content is related to hepatoprotective [ 12 ], antioxidant [ 13 ], anti-inflammatory [ 14 ], and antiviral [ 15 ] effects. We previously found that polyphenol-rich Canarium album extract (CAext) restrains excessive lipid accumulation induced by oleic acid in hepatocarcinoma cells [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet

Zhang

Guo

et al. 2018

Molecules

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This study investigated the influence of Canarium album extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of Firmicutes and Verrucomicrobia, but a decrease of Bacteroidetes in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of Akkermansia. These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on Akkermansia.

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Gut Microbiota Modulation and Anti-Inflammatory Properties of Dietary Polyphenols in IBD: New and Consolidated Perspectives

Abstract: In this review, we will focus on the dietary flavonols, anthocyanins and stilbenes, as widely occurring polyphenols in human diet, their metabolism mediated by gut microbiota and their protective effects on inflammatory bowel diseases (IBDs).

Cited by 50 publications

References 2 publications

Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

Phytochemical Analysis and Antioxidant Properties in Colored Tiggiano Carrots

Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet

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