Gut microbiota modulation: a tool for the management of colorectal cancer

Wang, Yan; Li, Hui

doi:10.1186/s12967-022-03378-8

Cited by 31 publications

(30 citation statements)

References 149 publications

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“…Traditional strategies related to the prevention and treatment of CRC include probiotics, prebiotics, high-fiber dietary therapy, and fecal microbiota transplantation (FMT), which have been comprehensively reviewed ( 27 ). Still, these approaches are limited by their own drawbacks (e.g.…”

Section: Gut Microbiota—a Potential Therapeutic Target For Crcmentioning

confidence: 99%

Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer

Yuan

Gui²,

Wang³

et al. 2023

Front. Immunol.

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Colorectal cancer (CRC) is one of the most common cancers, with a high mortality rate, and is a major burden on human health worldwide. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, which act as signaling molecules and substrates for metabolic reactions in various biological processes. The importance of host-gut microbiota interactions in immunometabolic mechanisms in CRC is increasingly recognized, and interest in modulating the microbiota to improve patient’s response to therapy has been raising. However, the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. Here we review recent advances and discuss the feasibility of gut microbiota as a regulatory target to enhance the immunogenicity of CRC, improve the radiosensitivity of colorectal tumor cells and ameliorate complications such as radiotoxicity. Currently, great breakthroughs in the treatment of non-small cell lung cancer and others have been achieved by radioimmunotherapy, but radioimmunotherapy alone has not been effective in CRC patients. By summarizing the recent preclinical and clinical evidence and considering regulatory roles played by microflora in the gut, such as anti-tumor immunity, we discuss the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC and expect this review can provide references and fresh ideas for the clinical application of this novel strategy.

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Section: Gut Microbiota—a Potential Therapeutic Target For Crcmentioning

confidence: 99%

Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer

Yuan

Gui²,

Wang³

et al. 2023

Front. Immunol.

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“…FMT reduces the severity of FOLFOX-induced diarrhea and intestinal mucosa and also restores the composition of the gut microbiota [ 116 ]. Importantly, imbalances or dysbiosis in the intestinal flora and bile acids play important roles in the development of CRC, and they can be used as biomarkers to predict therapeutic efficacy and for improving cancer treatment through the adjustment of the intestinal flora [ 117 ].…”

Section: Interaction Between Intestinal Flora and Bile Acidsmentioning

confidence: 99%

Interactive Relationships between Intestinal Flora and Bile Acids

Guo

Okpara

et al. 2022

IJMS

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The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans and animals, particularly those involved in the maintenance of intestinal homeostasis, immunity, inflammation, and tumorigenesis. The diversity of bile acids is a result of the joint efforts of host and intestinal microflora. There is a bidirectional relationship between the microbial community of the intestinal tract and bile acids in that, while the microbial flora tightly modulates the metabolism and synthesis of bile acids, the bile acid pool and composition affect the diversity and the homeostasis of the intestinal flora. Homeostatic imbalances of bile acid and intestinal flora systems may lead to the development of a variety of diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), and polycystic ovary syndrome (PCOS). The interactions between bile acids and intestinal flora may be (in)directly involved in the pathogenesis of these diseases.

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“…There are many factors affecting the development of cancer. In addition to lifestyle, genetic and epigenetic changes, and environmental factors, it is gradually being proven that the composition and changes in the gut microbiota also make a difference [ 15 ]. The human gut microbiota is made up of 100 trillion archaeal and bacterial cells, distributed over more than 1000 species, and its impact on human health is clear.…”

Section: The Relationship Between the Gut Microbiota And Cancermentioning

confidence: 99%

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Zuo

et al. 2022

Nutrients

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Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.

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Gut microbiota modulation: a tool for the management of colorectal cancer

Cited by 31 publications

References 149 publications

Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer

Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer

Interactive Relationships between Intestinal Flora and Bile Acids

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

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