Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Xu, Xiaoming; Li, Guoliang; Zhang, Da; Zhu, Hanyi; Liu, Guang‐hui; Zhang, Zhibin

doi:10.1002/advs.202205346

Cited by 5 publications

(1 citation statement)

References 95 publications

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“…The relationship between gut microbiota and host health have been studied in many species, such as Cuon alpinus , Lasiopodomys brandtii ( Bo et al, 2022 ; Sekirov et al, 2010 ; Wu et al, 2022 , 2016 ; Xu et al, 2023 ). The gut microbiota is considered to be an important factor affecting the immune system and brain activity of host, and the imbalance of gut microbiota may lead to obesity and cardiovascular disease ( Lee & Hase, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the fecal microbiota of healthy and injured common kestrel (Falco tinnunculus) from the Beijing Raptor Rescue Center

Guan,

Bao,

Zhou

et al. 2023

PeerJ

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The gut microbiota is a complex ecosystem that interacts with many other factors to affect the health and disease states of the host. The common kestrel (Falco tinnunculus) is protected at the national level in China. However, the available sequencing data of the gut microbiota from the feces of wild common kestrels, especially for being rescued individuals by professional organization, remains limited. In the present study, we characterized the fecal bacterial communities of healthy and injured common kestrels, and compared the structure of their fecal microbiota by analyzing the V3–V4 region of the 16S rRNA gene using high-throughput sequencing technology with the Illumina MiSeq platform. We found that Firmicutes, Proteobacteria and Actinobacteria were the most predominant phyla in common kestrels. Further, the beta diversity analysis showed that changes in gut microbes were associated with injuries to the common kestrel. The Bacteroides/Firmicutes ratio was significantly lower in the injured group. At the genus level, Glutamicibacter showed significant difference in the two groups. The aim of our current study was to characterize the basic bacterial composition and community structure in the feces of healthy common kestrels, and then compare the differences in the fecal microbiota between healthy and injured individuals. Patescibacteria, Spirochaetes, and Glutamicibacter may be studied as potential biomarkers for certain diseases in raptors. The results could provide the basic data for additional research on the fecal microbiota of common kestrels and contribute to the rescue of wild raptors in the future.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of the fecal microbiota of healthy and injured common kestrel (Falco tinnunculus) from the Beijing Raptor Rescue Center

Guan,

Bao,

Zhou

et al. 2023

PeerJ

View full text Add to dashboard Cite

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Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Zhang

et al. 2023

Advanced Science

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Humans and animals frequently encounter high‐density crowding stress, which may accelerate their aging processes; however, the roles of gut microbiota in the regulation of aging‐related processes under high‐density crowding stress remain unclear. In the present study, it is found that high housing density remarkably increases the stress hormone (corticosterone), accelerates aging‐related processes as indicated by telomere length (in brain and liver cells) and DNA damage or inflammation (as revealed by tumor necrosis factor‐α and interleukin‐10 levels), and reduces the lifespan of Brandt's vole (Lasiopodomys brandtii). Fecal microbiota transplantation from donor voles of habitats with different housing densities induces similar changes in aging‐related processes in recipient voles. The elimination of high housing density or butyric acid administration delays the appearance of aging‐related markers in the brain and liver cells of voles housed at high‐density. This study suggests that gut microorganisms may play a significant role in regulating the density‐dependent aging‐related processes and subsequent population dynamics of animals, and can be used as potential targets for alleviating stress‐related aging in humans exposed to high‐density crowding stress.

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Comparative analysis of the gut microbiome of ungulate species from Qinghai–Xizang plateau

Wang,

Gao,

Chen

et al. 2024

Ecology and Evolution

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Several studies have investigated the gut bacterial composition of wild ungulates in the Qinghai–Xizang Plateau. However, the relationship between their gut microbiome dendrograms and their phylogenetic tree remains unclear. In this study, we analyzed 45 amplicons (V3–V4 region of the 16S rRNA gene) from five wild ungulates—Pseudois nayaur, Pantholops hodgsonii, Gazella subgutturosa, Bos grunniens, and Equus kiang—from the Qinghai–Xizang Plateau to clarify the relationship between their phylogenies and gut microbiome dendrograms. The unweighted pair group method with arithmetic mean analysis and hierarchical clustering analysis indicated that G. subgutturosa is closely related to P. nayaur; however, these results were inconsistent with their phylogenetic trees. Additionally, the indicator genera in the microbiome of each wild ungulate showed strong associations with the diets and habitats of their host. Thus, diet and space niche differentiation may primarily account for the differences between the gut microbiome characteristics of these wild ungulates and their phylogeny. In summary, our research provides insights into the evolutionary factors influencing the gut microbiome of wild ungulates in the Qinghai–Xizang Plateau.

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Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Cited by 5 publications

References 95 publications

Comparative analysis of the fecal microbiota of healthy and injured common kestrel (Falco tinnunculus) from the Beijing Raptor Rescue Center

Comparative analysis of the fecal microbiota of healthy and injured common kestrel (Falco tinnunculus) from the Beijing Raptor Rescue Center

Gut Microbiota is Associated with Aging‐Related Processes of a Small Mammal Species under High‐Density Crowding Stress

Comparative analysis of the gut microbiome of ungulate species from Qinghai–Xizang plateau

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