Gut microbiota in patients with Alzheimer’s disease spectrum: a systematic review and meta-analysis

Abstract

Context: Gut dysbiosis has been proposed as one of pathologies in patients with Alzheimer’s disease (AD) spectrum. Despite such enthusiasm, the relevant results remain substantially controversial. Objective: A systematic review and meta-analysis were performed to investigate the differences of gut microbiota (GM) between patients with AD spectrum (including mild cognitive impairment [MCI] and AD) and healthy controls (HC). Data sources: PubMed, MEDLINE, Scopus, and Cochrane Library from January 2000 to August 2021. Eligibility criteria for study selection: Observational trials and pre-intervention data of intervention trials that investigated the abundance of GM in patients with AD spectrum and HC. Data extraction and synthesis: Two reviewers independently identified articles, extracted data, and evaluated the risk of bias. The effect sizes were performed by a random-effect, inverse-variance weighted model. The effects of different countries and of clinical stages on GM abundance were also examined. Results: 11 studies consisting of 378 HC and 427 patients with AD spectrum were included in the meta-analysis. Patients with AD, but not MCI, showed significantly reduced GM diversity as compared to HC. We also found more abundance of Proteobacteria , Bifidobacterium and Phascolarctobacterium , but less abundance of Firmicutes , Clostridiaceae , Lachnospiraceae and Rikenellaceae in patients with AD spectrum as compared with HC. The profiles of abundance of Alistipes and Bacteroides in HC and AD spectrum were differentially affected by countries. Finally, when considering clinical stage as a moderator, the comparisons of abundance in Clostridiaceae and Phascolarctobacterium showed large effect sizes, with gradient changes from MCI to AD stage. Limitations: The inclusion of studies originating only from China and the U.S. was a possible limitation. Conclusions: Patients with AD spectrum demonstrated altered GM abundance, which was differentially mediated by countries and clinical stages.

Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

“…Guo et al reported that patients with AD had increased Prevotella at the genus level compared with healthy controls [ 51 ]. Phascolarctobacterium can produce short-chain fatty acids, including acetate and propionate, and is more abundant in the AD spectrum [ 52 ]. Bifidobacterium is a dominant genus in the human gut, and both decrease and increase in abundance in AD patients have been reported [ 48, 52 ].…”

A comparison of the composition and functions of the oral and gut microbiotas in Alzheimer’s patients

“…(2021) reported the abundances of Proteobacteria and Gammaproteobacteria were higher in participants with MCI when compared with those in healthy controls. A meta-analysis further showed that the abundance of the Proteobacteria phylum increased progressively from an NC group to a MCI and an AD group ( Hung et al., 2022 ).…”

The Effect of Music-Based Intervention on General Cognitive and Executive Functions, and Episodic Memory in People with Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Recent Randomized Controlled Trials

“…Based on the previous studies [ 23 , 24 , 25 , 26 ], we set the inclusion and exclusion criteria. Randomized controlled trials were included if they met the following inclusion criteria: (1) participants with clinical diagnosis of dementia or cognitive impairment.…”