Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies

Liu, Liping; Wu, Qin; Chen, Yuping; Ren, Haoran; Zhang, Qi; Yang, Hengyue; Zhang, Wenying; Ding, Ting-Yu; Wang, Shujie; Zhang, Yan; Liu, Yun; Sun, Jihu

doi:10.1016/j.intimp.2023.109685

Cited by 13 publications

(2 citation statements)

References 122 publications

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“…40 Related studies have demonstrated that the homeostasis of the host GIT microbiota can contribute to inflammation, inhibition, and metabolism regulation, hence improving chronic disease. 41 Here, we observed lower abundance and diversity of the gut microbiome in the asthmatic mice vs. the control mice (Fig. 5a).…”

Section: Paper Food and Functionmentioning

confidence: 62%

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Guo,

Shi,

et al. 2023

Food Funct.

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Section: Paper Food and Functionmentioning

confidence: 62%

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Guo,

Shi,

et al. 2023

Food Funct.

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“…Determination of the microbiome alteration in migraine patients can help guide the personalization of microbiome-based migraine treatments, which can be in the form of dietary interventions or supplementation by microbiome metabolites. Targeting gut microbiota may therefore be a potential future treatment option for migraine [77].…”

Section: Dietary Approaches For Migrainementioning

confidence: 99%

Diet and migraine: what is proven?

Gazerani

2023

Current Opinion in Neurology

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Purpose of review The purpose of this review is to present the latest research findings about diet and migraine, what can be used in the clinic now, and what needs further investigation. Recent findings Recent findings highlight that dietary triggers exist for migraine, for example, coffee and alcohol, according to a new systematic review. Elimination diets must be personalized to delineate a balanced diet with acceptable quality and pattern. A piece of average-quality evidence shows that the ketogenic diet (KD) and the Dietary Approaches to Stop Hypertension (DASH) are effective in reducing the frequency, duration, and severity of migraine headaches in adult patients. The gut microbiome is altered in patients with migraine, and further research will identify the benefits of pre and probiotic use for migraine. Advanced digital technology in continuous monitoring can provide educational content based on patients’ needs, help patients adhere to dietary plans, and strengthen personalized care. The complex interaction of lifestyle factors, the influence of age and sex, and patients’ needs in various life phases are essential in formulating dietary plans. Summary The diet-migraine interaction is a dynamic bidirectional phenomenon that requires careful monitoring, review, and justification of dietary choices to yield the optimal outcome while minimizing potential risks.

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Risk of fibromyalgia following antibiotic prescriptions: A population‐based case–control study

Armstrong,

Dregan,

Ashworth

et al. 2024

European Journal of Pain

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BackgroundThe health of the gut microbiome is now recognized to be an important component of the gut–brain axis which itself appears to be implicated in pain perception. Antibiotics are known to create dysbiosis in the microbiome, so whether fibromyalgia is more commonly diagnosed after antibiotic prescriptions provides a means of exploring the role of the microbiome in the experience of chronic pain.MethodsA case–control study was carried out using electronic health records collected in the UK's Clinical Practice Research Datalink (CPRD), a comprehensive database of primary care consultations. For each case of diagnosed fibromyalgia, three controls were identified and matched by age, gender and GP practice. The exposure variable was the number and timing of antibiotic prescriptions over previous years. The analysis involved adjusting for a wide range of co‐variates that might be possible confounders.ResultsA total of 44,674 cases of fibromyalgia were identified together with 133,513 controls. After adjusting for co‐variates, it was found that both the total number of prescriptions and their timing was associated with an FM diagnosis. For example, the quartile with the highest number of prescriptions and that with the longest exposure had a greater than three‐fold increase in FM diagnoses (number of prescriptions: odds ratio 3.92; 95% CIs: 3.71–4.13; exposure odds ratio 3.28; CIs: 3.13–3.43). Some antibiotics (such as tetracyclines and metronidazole) seemed to confer greater risk than others.ConclusionsThe results lend support for prior antibiotics being an important risk factor for a diagnosis of FM.SignificanceThis study shows an association between the volume as well as timing of prior antibiotic prescriptions and of a subsequent diagnosis of fibromyalgia in primary care.

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Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies

Cited by 13 publications

References 122 publications

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Diet and migraine: what is proven?

Risk of fibromyalgia following antibiotic prescriptions: A population‐based case–control study

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