Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19

Luo, Jia; Shan, Liang; Jin, Feng

doi:10.1007/s11427-020-1847-7

Cited by 21 publications

(24 citation statements)

References 133 publications

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“…In humans, the endogenous source of α-Gal is gut bacteria ( 78 ), and glycan metabolism has a key role in shaping microbiota composition ( 82 ). Therefore, the dysregulation in C3 and HBB serum protein levels observed in COVID-19 cohorts and previously reported in response to α-Gal51 may be due to gut microbiota dysbiosis associated to SARS-CoV-2 infection and COVID-19 severity ( 83 , 84 ) ( Supplementary Figure 8 ). Apolipoprotein A (APOA) isoforms A-I, A-II, and A-IV were significantly dysregulated in COVID-19 patients and serum protein levels decreased with disease symptomatology ( Figure 4 and Supplementary Data 1 ).…”

Section: Discussionsupporting

confidence: 59%

Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology

et al. 2021

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The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors affecting disease progression and severity. The identification of prognostic biomarkers and physiological processes associated with disease symptoms is relevant for the development of new diagnostic and therapeutic interventions to contribute to the control of this pandemic. To address this challenge, in this study, we used a quantitative proteomics together with multiple data analysis algorithms to characterize serum protein profiles in five cohorts from healthy to SARS-CoV-2-infected recovered (hospital discharge), nonsevere (hospitalized), and severe [at the intensive care unit (ICU)] cases with increasing systemic inflammation in comparison with healthy individuals sampled prior to the COVID-19 pandemic. The results showed significantly dysregulated proteins and associated biological processes and disorders associated to COVID-19. These results corroborated previous findings in COVID-19 studies and highlighted how the representation of dysregulated serum proteins and associated BPs increases with COVID-19 disease symptomatology from asymptomatic to severe cases. The analysis was then focused on novel disease processes and biomarkers that were correlated with disease symptomatology. To contribute to translational medicine, results corroborated the predictive value of selected immune-related biomarkers for disease recovery [Selenoprotein P (SELENOP) and Serum paraoxonase/arylesterase 1 (PON1)], severity [Carboxypeptidase B2 (CBP2)], and symptomatology [Pregnancy zone protein (PZP)] using protein-specific ELISA tests. Our results contributed to the characterization of SARS-CoV-2–host molecular interactions with potential contributions to the monitoring and control of this pandemic by using immune-related biomarkers associated with disease symptomatology.

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Section: Discussionsupporting

confidence: 59%

Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology

et al. 2021

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“…The composition of gut microflora in patients with COVID-19 and even recovered patients is unbalanced, which is characterized by the decrease of beneficial microbes and the increase of harmful ones ( Yeoh et al, 2021 ). These results suggest that the GI disorders caused by COVID-19 are mainly due to the destruction of intestinal mechanical barrier integrity, alteration of the intestinal microflora, and systemic inflammatory response to the virus ( Luo et al, 2021 ; Syed et al, 2020 ; Villapol, 2020 ). Therefore, it is recommended to properly add beneficial intestinal microbes, especially probiotics and prebiotics, which may enhance the intestinal barrier function, help to improve and alleviate the sequela of COVID-19 and accelerate the complete recovery of patients.…”

Section: Current Concerns and Suggestions On Sars-cov-2 Mutationmentioning

confidence: 91%

“…The gut microbiome plays important role in modulating host immune response and affecting viral pathogenesis and secondary infection in the gastrointestinal (GI) tract. As reported, patients infected with SARS-CoV-2 show a wide range of GI disorders, including anorexia, nausea, vomiting, and abdominal pain ( Luo et al, 2021 ). The gut microbiome is also associated with the COVID-19 severity and levels of plasma concentrations of cytokines, chemokines, and inflammation markers ( Luo et al, 2021 ; Yeoh et al, 2021 ).…”

Section: Current Concerns and Suggestions On Sars-cov-2 Mutationmentioning

confidence: 93%

“…As reported, patients infected with SARS-CoV-2 show a wide range of GI disorders, including anorexia, nausea, vomiting, and abdominal pain ( Luo et al, 2021 ). The gut microbiome is also associated with the COVID-19 severity and levels of plasma concentrations of cytokines, chemokines, and inflammation markers ( Luo et al, 2021 ; Yeoh et al, 2021 ). The composition of gut microflora in patients with COVID-19 and even recovered patients is unbalanced, which is characterized by the decrease of beneficial microbes and the increase of harmful ones ( Yeoh et al, 2021 ).…”

Section: Current Concerns and Suggestions On Sars-cov-2 Mutationmentioning

confidence: 93%

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Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic

Zhang

Chen

et al. 2021

Infection, Genetics and Evolution

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Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has caused a global pandemic in the past year, which poses continuing threat to human beings. To date, more than 3561 mutations in the viral spike protein were identified, including 2434 mutations that cause amino acid changes with 343 amino acids located in the viral receptor-binding domain (RBD). Among these mutations, the most representative ones are substitution mutations such as D614G, N501Y, Y453F, N439K/R, P681H, K417N/T, and E484K, and deletion mutations of ΔH69/V70 and Δ242–244, which confer the virus with enhanced infectivity, transmissibility, and resistance to neutralization. In this review, we discussed the recent findings of SARS-CoV-2 for highlighting mutations and variants on virus transmissibility and pathogenicity. Moreover, several suggestions for prevention and controlling the pandemic are also proposed

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“…Bats are considered by many to be natural reservoirs for many viruses [233], including Ebola [234] and other SARS-like coronaviruses [235]. An apparent high tolerance for viruses in the Chiropterans that are lethal to many other species has been well-noted in the literature [236,237], and may be an indirect consequence of the evolution of flight in these species [238]. These authors argue that the metabolic demands of flight have intersected with immune system and gut microbiology evolution in the chiropterans in a way that makes these animals uniquely able to tolerate a diversity of viruses, and unfortunately for other species, to be able to spread those viruses through their feces and saliva.…”

Section: The Rodentiamentioning

confidence: 99%

Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic

Ekstrand

Flanagan

Lin

et al. 2021

Animals

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The accelerated pace of research into Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) necessitates periodic summaries of current research. The present paper reviews virus susceptibilities in species with frequent human contact, and factors that are best predictors of virus susceptibility. Species reviewed were those in contact with humans through entertainment, pet, or agricultural trades, and for whom reports (either anecdotal or published) exist regarding the SARS-CoV-2 virus and/or the resulting disease state COVID-19. Available literature was searched using an artificial intelligence (AI)-assisted engine, as well as via common databases, such as Web of Science and Medline. The present review focuses on susceptibility and transmissibility of SARS-CoV-2, and polymorphisms in transmembrane protease serine 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) that contribute to species differences. Dogs and pigs appear to have low susceptibility, while ferrets, mink, some hamster species, cats, and nonhuman primates (particularly Old World species) have high susceptibility. Precautions may therefore be warranted in interactions with such species, and more selectivity practiced when choosing appropriate species to serve as models for research.

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Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19

Cited by 21 publications

References 133 publications

Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology

Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 Symptomatology

Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic

Animal Transmission of SARS-CoV-2 and the Welfare of Animals during the COVID-19 Pandemic

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