Gut Microbiota

Chaluvadi, Saikiran; Hotchkiss, Arland T.; Yam, Kit L.

doi:10.1016/b978-0-12-802189-7.00036-8

Cited by 17 publications

(12 citation statements)

References 33 publications

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“…While many foodstuffs and their precursors have an abundant amount of postbiotics that are naturally present (e.g., yogurt, kefir, and pickled vegetables) (Chaluvadi et al, 2015). Instead of being manufactured in situ by the producing strain, various postbiotics have been introduced to meals.…”

Section: Appli C Ati On S Of P Os Tb I Oti C S In Food and Pharmaceut...mentioning

confidence: 99%

“…So, particular soluble components from certain bacteria may become a type of bacterial biological approach for treating a variety of disorders. While many foodstuffs and their precursors have an abundant amount of postbiotics that are naturally present (e.g., yogurt, kefir, and pickled vegetables) (Chaluvadi et al, 2015). Instead of being manufactured in situ by the producing strain, various postbiotics have been introduced to meals.…”

Section: Applications Of Postbiotics In Food and Pharmaceutical Indus...mentioning

confidence: 99%

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Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Asif,

Afzaal,

Shahid

et al. 2023

Food Science & Nutrition

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Functional foods are gaining significant research attention of researchers due to their health‐endorsing properties due to their bioactive components either living cells (probiotics) or nonviable cells (prebiotics). The term “postbiotic” specifies the soluble substances, such as enzymes, peptides, teichoic acids, muropeptides derived from peptidoglycans, polysaccharides, cell surface proteins, and organic acids, that are secreted by living bacteria or released after bacterial lysis. Due to various signaling molecules which may have antioxidant, immunomodulatory, antiinflammatory, antihypertensive, and antiproliferative activities, postbiotics offer great potential to be used in pharmaceutical, food, and nutraceutical industries, to promote health and ailment prevention. This recent review is a landmark of information relevant to the production of postbiotics along with salient features to use in various fields ranging from food to immunomodulation and selective and effective therapy. It also puts forward the concept that postbiotics are way more effective than probiotics in the veterinary, food as well as medical field which ultimately helps in reducing the disease burden along with human health.

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Section: Appli C Ati On S Of P Os Tb I Oti C S In Food and Pharmaceut...mentioning

confidence: 99%

Section: Applications Of Postbiotics In Food and Pharmaceutical Indus...mentioning

confidence: 99%

Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Asif,

Afzaal,

Shahid

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Probiotics are live beneficial microbes, prebiotics are food for these microbes, and postbiotics are the beneficial compounds produced by probiotics. Each plays a distinct role in the symbiotic relationship with the human host and significantly contributes to the body's overall homeostasis 22 . Probiotics are often consumed in fermented foods or dietary supplements and have been studied for their potential to improve gut health, immune function, and more 17 .…”

Section: Introductionmentioning

confidence: 99%

Probiotics, prebiotics, and postbiotics in health and disease

Ji,

Jin,

Liu

et al. 2023

MedComm

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The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the gut microbiota, current traditional medicines can only relieve symptoms, and it is difficult to solve the root causes or even cause side effects like disturbances in the gut microbiota. Increasing clinical studies and evidences have demonstrated that probiotics, prebiotics, and postbiotics can prevent and treat various diseases, but currently they can only be used as dietary supplements rather than medicines, which restricts the application of probiotics in the field of medicine. Here, this review analyzes the importance of gut microbiota in human health and the current problems of traditional medicines, and systematically summarizes the effectiveness and mechanisms of probiotics, prebiotics, and postbiotics in maintaining health and treating diseases based on animal models and clinical trials. And based on current research outcomes and development trends in this field, the challenges and prospects of their clinical application in maintaining health, alleviating and treating diseases are analyzed. It is hoped to promote the application of probiotics, prebiotics, and postbiotics in disease treatment and open up new frontiers in probiotic research.

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“…Others, such as some amino acid derivates or trimethylamine‐oxide (TMAO) are largely associated with noxious effects contributing to disease pathogenesis (Agus et al , 2021 ). Insights into the mechanism of action and modulation of these microbial products may enable their integration as therapeutics (Chaluvadi et al , 2016 ), a modality recently termed postbiotic treatment (Aguilar‐Toalá et al , 2018 ). A recent consensus statement by the International Scientific Association of Probiotics and Prebiotics (ISAPP) proposed to integrate supplementation with inactivated microorganisms (Salminen et al , 2021 ) into this term.…”

Section: Introductionmentioning

confidence: 99%

Local and systemic effects of microbiome‐derived metabolites

2022

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Commensal microbes form distinct ecosystems within their mammalian hosts, collectively termed microbiomes. These indigenous microbial communities broadly expand the genomic and functional repertoire of their host and contribute to the formation of a “meta‐organism.” Importantly, microbiomes exert numerous biochemical reactions synthesizing or modifying multiple bioactive small molecules termed metabolites, which impact their host's physiology in a variety of contexts. Identifying and understanding molecular mechanisms of metabolite–host interactions, and how their disrupted signaling can contribute to diseases, may enable their therapeutic application, a modality termed “postbiotic” therapy. In this review, we highlight key examples of effects of bioactive microbe‐associated metabolites on local, systemic, and immune environments, and discuss how these may impact mammalian physiology and associated disorders. We outline the challenges and perspectives in understanding the potential activity and function of this plethora of microbially associated small molecules as well as possibilities to harness them toward the promotion of personalized precision therapeutic interventions.

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Gut Microbiota

Cited by 17 publications

References 33 publications

Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Probing the functional and therapeutic properties of postbiotics in relation to their industrial application

Probiotics, prebiotics, and postbiotics in health and disease

Local and systemic effects of microbiome‐derived metabolites

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