Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity — a preliminary report

Liang, Yuanjiao; Qi, Ming; Liang, Jinlan; Zhang, Yan; Zhang, Hong; Shen, Tao

doi:10.1139/cjpp-2019-0413

Cited by 60 publications

(54 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Letrozole treatment of adult mice also resulted in a higher relative abundance of genera from Lachnospiraceae, Ruminococcaceae, and Peptococcaceae, and lower Lactobacillus [52]. In a recent human study, Bacteroidetes, Firmicutes, and Verrucomicrobia phyla differed between women with PCOS and controls, with obesity having a driving role in the development of dysbiotic microbiota [53]. In particular, women with PCOS had higher relative abundances of several Ruminococcus spp.…”

Section: Effects Of Testosteronementioning

confidence: 93%

Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

et al. 2020

View full text Add to dashboard Cite

Background Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the gonadal steroid status. Therefore, we investigated the gut microbiome composition and functionality in relation to sex, menopausal status, and circulating sex steroids. Results No significant differences were found in alpha diversity indices among pre- and post-menopausal women and men, but beta diversity differed among groups. The gut microbiota from post-menopausal women was more similar to men than to pre-menopausal women. Metagenome functional analyses revealed no significant differences between post-menopausal women and men. Gonadal steroids were specifically associated with these differences. Hence, the gut microbiota of pre-menopausal women was more enriched in genes from the steroid biosynthesis and degradation pathways, with the former having the strongest fold change among all associated pathways. Microbial steroid pathways also had significant associations with the plasma levels of testosterone and progesterone. In addition, a specific microbiome signature was able to predict the circulating testosterone levels at baseline and after 1-year follow-up. In addition, this microbiome signature could be transmitted from humans to antibiotic-induced microbiome-depleted male mice, being able to predict donor’s testosterone levels 4 weeks later, implying that the microbiota profile of the recipient mouse was influenced by the donor’s gender. Finally, obesity eliminated most of the differences observed among non-obese pre-menopausal women, post-menopausal women, and men in the gut microbiota composition (Bray-Curtis and weighted unifrac beta diversity), functionality, and the gonadal steroid status. Conclusions The present findings evidence clear differences in the gut microbial composition and functionality between men and women, which is eliminated by both menopausal and obesity status. We also reveal a tight link between the gut microbiota composition and the circulating levels of gonadal steroids, particularly testosterone.

show abstract

Section: Effects Of Testosteronementioning

confidence: 93%

Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Two groups of beneficial bacteria are dominant in the human gut: Bacteroidetes and Firmicutes (Rinninella et al 2019). Several studies have shown that obesity is related to dysbiosis in the intestinal microbiota in children, adolescents, and adults (Chen, Sun, et al 2020;Jobira et al 2020;Liang et al 2020;Riva et al 2017). Riva et al evidenced an increase and shifts in the phylum Firmicutes and a decrease in Bacteroidetes in fecal samples (Riva et al 2017).…”

Section: The Microbiota Gut-lung Axis and Immune Response In Obesitymentioning

confidence: 99%

Obesity as a risk factor for COVID-19: an overview

Alberca

Oliveira

Branco

et al. 2020

Critical Reviews in Food Science and Nutrition

125

127

View full text Add to dashboard Cite

The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for healthcare systems worldwide. Many different risk factors are associated with disease severity, such as older age, diabetes, hypertension, and most recently obesity. The incidence of obesity has been on the rise for the past 25 years, reaching over 2 billion people throughout the world, and obesity itself could be considered a pandemic. In this review, we summarize aspects involved with obesity, such as changes in the immune response, nutritional factors, physiological factors, and the gutlung axis, that impact the viral response and the COVID-19 prognosis.

show abstract

“…Of the genera within phylum Bacteroidetes , Bacteroides were positively associated with PCOS in 5/7 studies and Parabacteroides were positively associated with PCOS in 2 studies [ 20 , 23–25 , 28 , 33 ], while the family S24-7 was negatively associated with PCOS in 2 studies [ 19 , 33 ]. Of the genera within phylum Firmicutes , family Clostridiaceae was positively associated with PCOS in 2 studies [ 22 , 25 ] and family Veillonellaceae in 2 other studies [ 27 , 33 ]. Of the genera within phylum Proteobacteria , Escherichia , and Shigella were positively associated with PCOS in 2 studies [ 20 , 22 ].…”

Section: Dysbiosis Of the Gut Microbiome Is Associated With Polycystimentioning

confidence: 99%

Intersection of Polycystic Ovary Syndrome and the Gut Microbiome

Rizk

Thackray

2020

Journal of the Endocrine Society

View full text Add to dashboard Cite

The etiology of polycystic ovary syndrome (PCOS) remains unclear although studies indicate that both genetic and environmental factors contribute to the syndrome. In 2012, Tremellen and Pearce proposed the idea that dysbiosis of the intestinal (gut) microbiome is a causative factor of metabolic and reproductive manifestations of PCOS. In the past five years, studies in both humans and rodent models have demonstrated that changes in the taxonomic composition of gut bacteria are associated with PCOS. Studies have also clearly shown that these changes in gut microbiota are associated with PCOS per se as opposed to obesity since these changes are observed in women with PCOS that are both normal weight or obese as well as in adolescent girls with PCOS and obesity compared to BMI- and age-matched females without the disorder. Additionally, studies in both women with PCOS and rodent models of PCOS demonstrated that hyperandrogenism is associated with gut microbial dysbiosis, indicating that androgens may modulate the gut microbial community in females. One study reported that fecal microbiome transplantation of stool from women with PCOS or exposure to certain bacteria resulted in a PCOS-like phenotype in mice while other studies showed that exposure to a healthy gut microbiome, pre/probiotics, or specific gut metabolites resulted in protection from developing PCOS-like traits in mice. Altogether, these results suggest that dysbiosis of the gut microbiome may be sufficient to develop PCOS-like symptoms and that modulation of the gut microbiome may be a potential therapeutic target for PCOS.

show abstract

Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity — a preliminary report

Cited by 60 publications

References 43 publications

Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

Obesity as a risk factor for COVID-19: an overview

Intersection of Polycystic Ovary Syndrome and the Gut Microbiome

Contact Info

Product

Resources

About