Gut microbiota dysbiosis in depressed women: The association of symptom severity and microbiota function

Chen, Yi-huan; Xue, Fen; Yu, Shou-fen; Li, Xiao-Sa; Liu, Ling; Jia, Yi‐Xia; Yan, Wenjun; Tan, Qihua; Wang, Huaning; Peng, Zhengwu

doi:10.1016/j.jad.2020.12.143

Cited by 50 publications

(79 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pooled estimate showed a significant decrease in patients with a small effect size (standardized mean difference [SMD] = −0.26; 95% CI, −0.47 to −0.06; P = .01) and high heterogeneity ( I 2 = 75%) ( Figure 1 A). 3 , 4 , 22 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 Within diagnostic categories, there was a significant decrease only in bipolar disorder (SMD = −0.61; 95% CI, −1.19 to −0.03; P = .04; I 2 = 80%). Twenty-six studies provided data on Chao1 in patients (n = 956) vs controls (n = 961).…”

Section: Resultsmentioning

confidence: 95%

“…Regarding individual diagnoses, there was a significant decrease only in bipolar disorder and anorexia nervosa (SMD = −0.53; 95% CI, −1.01 to −0.05; P = .03; I 2 = 62% and SMD = −0.86; 95% CI, −1.52 to −0.21; P = .01; I 2 = 80%, respectively) ( Figure 1 B). 4 , 21 , 25 , 27 , 29 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Perturbations in Gut Microbiota Composition in Psychiatric Disorders

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Perturbations in Gut Microbiota Composition in Psychiatric Disorders

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Biomarker discovery is one of the most important means being used for reflecting the lifestyle and disease of various hosts (Di Paola et al, 2011;Segata et al, 2011;Zhimo et al, 2021). It has been proven that Random Forest can effectively, stably, and accurately classify microbial community samples (Yatsunenko et al, 2012;Chen et al, 2021). Botryosphaeria and Fusarium were identified as biomarkers in this study to distinguish between 1-MCP treatment and untreated control pear fruits.…”

Section: Discussionmentioning

confidence: 88%

Dynamic Microbiome Changes Reveal the Effect of 1-Methylcyclopropene Treatment on Reducing Post-harvest Fruit Decay in “Doyenne du Comice” Pear

et al. 2021

View full text Add to dashboard Cite

Pathogen-induced decay is one of the most common causes of fruit loss, resulting in substantial economic loss and posing a health risk to humans. As an ethylene action inhibitor, 1-methylcyclopropene (1-MCP) can significantly reduce fruit decay, but its effect on fruit pathogens remains unclear. Herein, the change in microbial community structure was analyzed using the high-throughput sequencing technology, and characteristics related to fruit quality were determined after 1-MCP (1.0 M l L–1) treatment in “Doyenne du Comiceis” pear fruit during storage at ambient temperature. Overall, 1-MCP was highly effective in reducing disease incidence and induced multiple changes of the fungal and bacterial microbiota. At day 15, the microbial diversity of fungi or bacteria was reduced significantly in the control fruit (non-treated with 1-MCP), which had the most severe decay incidence. For fungi, in addition to Alternaria being the most abundant in both 1-MCP treatment (59.89%) and control (40.18%), the abundances of Botryosphaeria (16.75%), Penicillium (8.81%), and Fusarium (6.47%) increased significantly with the extension of storage time. They became the primary pathogens to cause fruit decay in control, but they were markedly decreased in 1-MCP treatment, resulting in reduced disease incidence. For bacteria, the abundance of Gluconobacter (50.89%) increased dramatically at day 15 in the control fruit, showing that it also played a crucial role in fruit decay. In addition, Botryosphaeria, Fusarium fungi, and Massilia, Kineococcus bacteria were identified as biomarkers to distinguish 1-MCP treatment and control using Random Forest analysis. The redundancy analysis (RDA) result showed that the amount of Botryosphaeria, Penicillium, and Fusarium were positively correlated with disease incidence and respiration rate of pear fruits while negatively correlated with fruit firmness. This investigation is the first comprehensive analysis of the microbiome response to 1-MCP treatment in post-harvest pear fruit, and reveals the relationship between fruit decay and microbial composition in pear fruit.

show abstract

“…Moreover, probiotics are able to sense and regulate the action of secondary metabolites (e.g., bacteriocins, enzymes, and exopolysaccharides). Probiotic rich diets, adjunctive probiotic supplementation, and the prescription of personalized probiotics based on previous microbial analysis (targeted gut microbiota modulation) are linked with the prevention and potential treatment of several severe disorders, such as inflammatory bowel diseases, colorectal cancer, obesity, diabetes, and cardiovascular diseases as well as food allergies, depression, and brain function [17,[46][47][48][49][50][51][52][53][54]. As the worldwide incidence of food allergies is increasing, there is an urgent need for well-controlled studies that demonstrate the positive outcomes of probiotics.…”

Section: Modulation By Probioticsmentioning

confidence: 99%

Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Kvaková

Bertková

Štofilová

et al. 2021

Foods

View full text Add to dashboard Cite

Growing interest in the development of innovative functional products as ideal carriers for synbiotics, e.g., nutrient bars, yogurt, chocolate, juice, ice cream, and cheese, to ensure the daily intake of probiotics and prebiotics, which are needed to maintain a healthy gut microbiota and overall well-being, is undeniable and inevitable. This review focuses on the modern approaches that are currently being developed to modulate the gut microbiota, with an emphasis on the health benefits mediated by co-encapsulated synbiotics and immobilized probiotics. The impact of processing, storage, and simulated gastrointestinal conditions on the viability and bioactivity of probiotics together with prebiotics such as omega-3 polyunsaturated fatty acids, phytochemicals, and dietary fibers using various delivery systems are considered. Despite the proven biological properties of synbiotics, research in this area needs to be focused on the proper selection of probiotic strains, their prebiotic counterparts, and delivery systems to avoid suppression of their synergistic or complementary effect on human health. Future directions should lead to the development of functional food products containing stable synbiotics tailored for different age groups or specifically designed to fulfill the needs of adjuvant therapy.

show abstract

Gut microbiota dysbiosis in depressed women: The association of symptom severity and microbiota function

Cited by 50 publications

References 74 publications

Perturbations in Gut Microbiota Composition in Psychiatric Disorders

Perturbations in Gut Microbiota Composition in Psychiatric Disorders

Dynamic Microbiome Changes Reveal the Effect of 1-Methylcyclopropene Treatment on Reducing Post-harvest Fruit Decay in “Doyenne du Comice” Pear

Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Contact Info

Product

Resources

About