Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Kvaková, Monika; Bertková, Izabela; Štofilová, Jana; Savidge, Tor

doi:10.3390/foods10061297

Cited by 39 publications

(37 citation statements)

References 247 publications

(287 reference statements)

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“…The combination instead of the single use of either probiotics or prebiotics, is to give superior outcome than when taken independently. Synbiotics can boost probiotics action by modulating essential metabolites production ( Kvakova et al, 2021 ). These microbial excretes can in turn exert hostility including biofilm inhibition against pathogens.…”

Section: Role Of Biotics In Preventing Biofilms Prevalence In Vulvova...mentioning

confidence: 99%

The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections

et al. 2022

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“Unity in strength” is a notion that can be exploited to characterize biofilms as they bestow microbes with protection to live freely, escalate their virulence, confer high resistance to therapeutic agents, and provide active grounds for the production of biofilms after dispersal. Naturally, fungal biofilms are inherently resistant to many conventional antifungals, possibly owing to virulence factors as their ammunitions that persistently express amid planktonic transition to matured biofilm state. These ammunitions include the ability to form polymicrobial biofilms, emergence of persister cells post-antifungal treatment and acquisition of resistance genes. One of the major disorders affecting vaginal health is vulvovaginal candidiasis (VVC) and its reoccurrence is termed recurrent VVC (RVVC). It is caused by the Candida species which include Candida albicans and Candida glabrata. The aforementioned Candida species, notably C. albicans is a biofilm producing pathogen and habitually forms part of the vaginal microbiota of healthy women. Latest research has implicated the role of fungal biofilms in VVC, particularly in the setting of treatment failure and RVVC. Consequently, a plethora of studies have advocated the utilization of probiotics in addressing these infections. Specifically, the excreted or released compounds of probiotics which are also known as postbiotics are being actively researched with vast potential to be used as therapeutic options for the treatment and prevention of VVC and RVVC. These potential sources of postbiotics are harnessed due to their proven antifungal and antibiofilm. Hence, this review discusses the role of Candida biofilm formation in VVC and RVVC. In addition, we discuss the application of pro-, pre-, post-, and synbiotics either individually or in combined regimen to counteract the abovementioned problems. A clear understanding of the role of biofilms in VVC and RVVC will provide proper footing for further research in devising novel remedies for prevention and treatment of vaginal fungal infections.

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Section: Role Of Biotics In Preventing Biofilms Prevalence In Vulvova...mentioning

confidence: 99%

The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections

et al. 2022

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“…The survivability and dose levels of probiotics during storage and delivery are important parameters for probiotic efficacy. During storage and delivery by oral administration, probiotics are exposed to water, oxygen, heat, strong acid and bile [ 13 , 14 ]. To overcome these adverse factors, various dosage forms, such as capsules, tablets, powders and liquids, have been used [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

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The probiotics market is one of the fastest growing segments of the food industry as there is growing scientific evidence of the positive health effects of probiotics on consumers. Currently, there are various forms of probiotic products and they can be categorized according to dosage form and the site of action. To increase the effectiveness of probiotic preparations, they need to be specifically designed so they can target different sites, such as the oral, upper respiratory or gastrointestinal tracts. Here we review the characteristics of different dosage forms of probiotics and discuss methods to improve their bioavailability in detail, in the hope that this article will provide a reference for the development of probiotic products.

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“…Symbiotic bacteria that colonize the human gut can be classified into several phyla comprising Bacteroidetes and Firmicutes, followed by Proteobacteria, Fusobacteria, Actinobacteria, Verrucomicrobia, and Spirochaetes. Microbiome composition varies between healthy individuals, as well as in CRC patients[ 7 ]. CRC-associated bacteria that have been identified to date include enrichment of Fusobacterium nucleatum , Enterococcus faecalis , Streptococcus gallolyticus , entero-toxigenic Bacteroides fragilis , Escherichia coli , Peptostreptococcus spp., and Ruminococcus spp.…”

Section: Introductionmentioning

confidence: 99%

Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy

Kvaková¹,

Kamlárová²,

Štofilová³

et al. 2022

WJG

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Colorectal cancer (CRC) is a leading cause of human mortality worldwide. As conventional anticancer therapy not always being effective, there is growing interest in innovative “drug-free” cancer treatments or interventions that improve the efficacy of established therapy. CRC is associated with microbiome alterations, a process known as dysbiosis that involves depletion and/or enrichment of particular gut bacterial species and their metabolic functions. Supplementing patient treatment with traditional probiotics (with or without prebiotics), next-generation probiotics (NGP), or postbiotics represents a potentially effective and accessible complementary anticancer strategy by restoring gut microbiota composition and/or by signaling to the host. In this capacity, restoration of the gut microbiota in cancer patients can stabilize and enhance intestinal barrier function, as well as promote anticarcinogenic, anti-inflammatory, antimutagenic or other biologically important biochemical pathways that show high specificity towards tumor cells. Potential benefits of traditional probiotics, NGP, and postbiotics include modulating gut microbiota composition and function, as well as the host inflammatory response. Their application in CRC prevention is highlighted in this review, where we consider supportive in vitro , animal, and clinical studies. Based on emerging research, NGP and postbiotics hold promise in establishing innovative treatments for CRC by conferring physiological functions via the production of dominant natural products and metabolites that provide new host-microbiota signals to combat CRC. Although favorable results have been reported, further investigations focusing on strain and dose specificity are required to ensure the efficacy and safety of traditional probiotics, NGP, and postbiotics in CRC prevention and treatment.

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Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Cited by 39 publications

References 247 publications

The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections

The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections

Characteristics of Probiotic Preparations and Their Applications

Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy

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