Gut microbiota disorder caused by diterpenoids extracted from <i>Euphorbia pekinensis</i> aggravates intestinal mucosal damage

Wang, Kuilong; Xu, Xiaojuan; Maimaiti, Aikebaier; Hao, Min; Sang, Xianan; Shan, Qiyuan; Wu, Xing-Zheng; Cao, Gang

doi:10.1002/prp2.765

Cited by 24 publications

(6 citation statements)

References 37 publications

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“…The development of obesity is associated with a number of factors, of which the gut microbiota is one of the key factors that has received a lot of attention in recent years and is a potential target for the prevention of obesity and related metabolic diseases. And nutrients and active substances in food can effectively regulate the gut microbiota (4)(5)(6), among which insoluble dietary fiber has a good effect on regulating the structure and function of the gut microbiota (7), but there is less research on obesity reduction and its mechanism of action (8,9). At the same time, the structure and function of different sources of dietary fiber vary greatly, and its effect on obesity and its mechanism of action are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Bamboo shoot dietary fiber alleviates gut microbiota dysbiosis and modulates liver fatty acid metabolism in mice with high-fat diet-induced obesity

Zhou¹,

Ma²,

Li³

et al. 2023

Front. Nutr.

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IntroductionObesity is a common nutritional disorder characterized by an excessive fat accumulation. In view of the critical role of gut microbiota in the development of obesity and metabolic diseases, novel dietary therapies have been developed to manage obesity by targeting the gut microbiome. In this study, we investigated anti-obesity effects of bamboo shoot dietary fiber (BSDF) and the potential mechanisms.MethodsAfter 12 weeks of intervention with BSDF in high-fat mice, we detected obesity-related phenotypic indicators, and made transcriptomic analysis of liver tissue. Then we analyzed the changes of gut microbiota using 16S rRNA gene sequencing, explored the effect of BSDF on gut microbiota metabolites, and finally verified the importance of gut microbiota through antibiotic animal model.Results and discussionWe found that BSDF was effective in reducing lipid accumulation in liver and adipose tissue and alleviating dyslipidemia and insulin resistance. Liver transcriptome analysis results showed that BSDF could improve lipid metabolism and liver injury by modulating peroxisome proliferator-activated receptor (PPAR) and fatty acid metabolic pathways. The 16S rRNA gene sequencing analysis of gut microbiota composition showed that BSDF significantly enriched beneficial bacteria such as Bifidobacterium, Akkermansia, Dubosiella, and Alloprevotella. Analysis of fecal metabolomics and gut microbiota metabolites revealed that BSDF increased the levels of several short-chain fatty acids and enriched bile acids, which may be important for improving lipid metabolism. Notably, the obesity-related metabolic disorders were abrogated after the abrogation of gut microbiota, suggesting that gut microbiota is a key factor in the beneficial effects of BSDF.ConclusionOur study suggests that BSDF as a prebiotic supplement has the potential to improve obesity by improving gut microbiota and modulating host PPAR and fatty acid metabolic pathways.

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Section: Introductionmentioning

confidence: 99%

Bamboo shoot dietary fiber alleviates gut microbiota dysbiosis and modulates liver fatty acid metabolism in mice with high-fat diet-induced obesity

Zhou¹,

Ma²,

Li³

et al. 2023

Front. Nutr.

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“…Currently, T2DM is considered to be a chronic inflammatory disease. In many studies related to intestinal inflammation, a significant increase in the abundance of Enterorhabdus has been observed ( Tang et al, 2021 ; Wang et al, 2021 ). It was also found that the abundance of Enterorhabdus was significantly increased in non-alcoholic fatty liver disease (NAFLD) mice ( Li et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut Microbiota

et al. 2022

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Type 2 diabetes mellitus (T2DM) is a major global health concern. Psidium guajava L. (guava) is widely used for food as well as a folk medicine. Previous studies have shown its anti-diabetic and anti-inflammatory properties. However, the underlying mechanisms remains to be elusive. In this study, we assessed the potential therapeutic effects of aqueous extract of guava leaves (GvAEx) on T2DM and explored their potential mechanisms in vivo and in vitro. GvAEx was gavage administered for 12 weeks in diabetic db/db mice. Our results have demonstrated that GvAEx significantly lowered fasting plasma glucose levels (p < 0.01) and improved glucose tolerance and insulin sensitivity (p < 0.01, p < 0.05, respectively). Additionally, GvAEx increased hepatic glycogen accumulation, glucose uptake and decreased the mRNA expression levels of gluconeogenic genes. Furthermore, GvAEx-treatment caused higher glucose transporter 2 (GLUT2) expression in the membrane in hepatocytes. Notably, for the first time, we have elaborated the possible mechanism of the hypoglycemic effect of GvAEx from the perspective of intestinal microbiota. GvAEx has significantly changed the composition of microbiota and increased short chain fatty acid (SCFA) -producing Lachnospiraceae family and Akkermansia genus in the gut. Taken together, GvAEx could alleviate hyperglycemia and insulin resistance of T2DM by regulating glucose metabolism in the liver and restoring the gut microbiota. Thus, GvAEx has the potential for drug development against T2DM.

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“…Although Firmicutes has been considered as a beneficial bacterium among intestinal microorganisms, the abnormal increase in Firmicutes and the decreased abundance of Bacteroidetes in the diseased group might be caused by obesity, as evidenced by the hepatocyte-filled adipocytes in the pathological sections of the liver diseased group. Increased abundance of Candidatus_Arthromitus is considered as a possible cause of enterocolitis ( Del-Pozo et al., 2010 ; Wang et al., 2021 ). Reduced abundance of colonized probiotic bacteria in the gut weakens the intestinal epithelial barrier and can cause failure of transmission of signals to the host that regulate the immune system ( Bermudez-Brito et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus sciuri causes disease and pathological changes in hybrid sturgeon acipenser baerii × acipenser schrencki

Zhang

Xue

Xiao

et al. 2022

Front. Cell. Infect. Microbiol.

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Hybrid sturgeon is the main species of sturgeon cultured in China, with the advantages of a fast growth rate, early sexual maturity, fertile offspring, and more stable genetic traits. In May 2021, a large number of deaths characterized by superficial hemorrhage and liver damage occurred in a sturgeon farm in Yichang, Hubei Province, which posed a significant risk to hybrid sturgeon captive breeding. We isolated a pathogenic bacterium named D-59 from the diseased sturgeon with apparent symptoms. The pathogen was identified as Staphylococcus sciuri using 16S rRNA gene phylogenetic analysis combined with biochemical identification. Regression experiments showed that D-59 exhibited clinical signs similar to those of diseased sturgeon in the farm after intraperitoneal injection into hybrid sturgeon. High-throughput sequencing of gut microbes in D-59-infected sturgeon showed that the number of gut microbial species decreased in infected sturgeon, the number of some intestinal commensal bacteria decreased, and the balance of the intestinal microorganisms was disrupted. Histopathological sections indicated many inflammatory cells, congestion, and even necrosis in the tissue of diseased sturgeon. Analysis of blood indexes revealed an increase in the proportion of mononuclear cells and a decrease in the proportion of lymphocytes in the peripheral blood of diseased sturgeon. Significantly elevated serum levels of aspartate aminotransferase and alanine aminotransferase, whereas alkaline phosphatase, total protein, albumin, and globulin were decreased in diseased sturgeon. Antimicrobial susceptibility tests demonstrated that D-59 is susceptible to florfenicol, enrofloxacin, and neomycin sulfate. This study aimed to highlight the dangers of Staphylococcus sciuri infection during hybrid sturgeon culture and to provide recommendations for diagnosis and treatment.

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Gut microbiota disorder caused by diterpenoids extracted from Euphorbia pekinensis aggravates intestinal mucosal damage

Cited by 24 publications

References 37 publications

Bamboo shoot dietary fiber alleviates gut microbiota dysbiosis and modulates liver fatty acid metabolism in mice with high-fat diet-induced obesity

Bamboo shoot dietary fiber alleviates gut microbiota dysbiosis and modulates liver fatty acid metabolism in mice with high-fat diet-induced obesity

Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut Microbiota

Staphylococcus sciuri causes disease and pathological changes in hybrid sturgeon acipenser baerii × acipenser schrencki

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