Gut microbiota-derived metabolites in obesity: a systematic review

Ejtahed, Hanieh‐Sadat; Soroush, Ahmadreza; Hasani‐Ranjbar, Shirin; Siadat, Seyed-Davar; Larijani, Bagher

doi:10.12938/bmfh.2019-026

Cited by 58 publications

(44 citation statements)

References 109 publications

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“…Gut microbiota-derived metabolites affect many biological processes of the host, including appetite control and weight management. Amino acids are among the gut microbiota-derived metabolites which have previously demonstrated alterations in obesity, indicating potential alternative health applications for glucosamine [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Glucosamine Supplementation on Gut Health

et al. 2021

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Glucosamine (GLU) is a natural compound found in cartilage, and supplementation with glucosamine has been shown to improve joint heath and has been linked to reduced mortality rates. GLU is poorly absorbed and may exhibit functional properties in the gut. The purpose of this study was to examine the impact of glucosamine on gastrointestinal function as well as changes in fecal microbiota and metabolome. Healthy males (n = 6) and females (n = 5) (33.4 ± 7.7 years, 174.1 ± 12.0 cm, 76.5 ± 12.9 kg, 25.2 ± 3.1 kg/m2, n = 11) completed two supplementation protocols that each spanned three weeks separated by a washout period that lasted two weeks. In a randomized, double-blind, placebo-controlled, crossover fashion, participants ingested a daily dose of GLU hydrochloride (3000 mg GlucosaGreen®, TSI Group Ltd., USA) or maltodextrin placebo. Study participants completed bowel habit and gastrointestinal symptoms questionnaires in addition to providing a stool sample that was analyzed for fecal microbiota and metabolome at baseline and after the completion of each supplementation period. GLU significantly reduced stomach bloating and showed a trend towards reducing constipation and hard stools. Phylogenetic diversity (Faith’s PD) and proportions of Pseudomonadaceae, Peptococcaceae, and Bacillaceae were significantly reduced following GLU consumption. GLU supplementation significantly reduced individual, total branched-chain, and total amino acid excretion, with no glucosamine being detected in any of the fecal samples. GLU had no effect on fecal short-chain fatty acids levels. GLU supplementation provided functional gut health benefits and induced fecal microbiota and metabolome changes.

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Section: Discussionmentioning

confidence: 99%

Impact of Glucosamine Supplementation on Gut Health

et al. 2021

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“…Hippurate is a glycine conjugate of benzoic acid formed in the mitochondria of the liver and kidneys and then excreted in the urine [ 72 ] and is considered a gut microbial-mammalian co-metabolite that can be made by Clostridium spp., primarily from polyphenols [ 73 ]. In our study, hippurate was reduced by a half in the CAF-R group compared to the STD-R group.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats

et al. 2021

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Obesity is one of the most incident and concerning disease worldwide. Definite strategies to prevent obesity and related complications remain elusive. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrimination on the different biomarkers in the obesity onset. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in o-coumaric acid. Hereby, we propose these metabolites as a metabolic profile associated to a segregated dysbiosis state related to obesity disease.

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“…There is a growing body of evidence that gut dysbiosis may contribute to the development and progression of obesity and CVD, primarily increasing oxidative and inflammation state [19,20]. Based on these data, several studies have analyzed how prebiotic and probiotic supplementation could be useful to restoring gut eubiosis and consequently improve cardiometabolic state [21].…”

Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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Gut microbiota-derived metabolites in obesity: a systematic review

Cited by 58 publications

References 109 publications

Impact of Glucosamine Supplementation on Gut Health

Impact of Glucosamine Supplementation on Gut Health

A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

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