Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis

Yang, Chengcheng; Du, Yao; Ren, Daoyuan; Yang, Xingbin; Zhao, Yan

doi:10.1039/d1fo01468d

Cited by 68 publications

(76 citation statements)

References 53 publications

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“…On the other hand, Lp082 also optimized species composition; that is, the abundance of pro-in ammatory microbiota decreased in the Lp082 group, such as Helicobacter hepaticus, a potential pathogen of colitis. Likewise, we observed an increasing trend in the abundance of potential probiotics in the Lp082 group, such as Bi dobacterium pseudolongum and Bacteroides ovatus, which reduces colonic in ammation [35], Parabacteroides distasonis, which is negatively associated with obesity and diabetes [36], Akkermansia muciniphila and Lactobacillus reuteri, a widely studied probiotic, Anaerotruncus sp G3 2012 and Lactobacillus plantarum, potential SCFAs-producing bacteria [37]. The above results indicate that Lp082 is bene cial to optimizing the diversity, structure, and composition of gut microbiota.…”

Section: Discussionsupporting

confidence: 51%

Probiotics (Lactiplantibacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related genes expression, gut microbiota, and metabolic pathways in mice

Jha

et al. 2022

Preprint

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Background: As a chronic relapsing disease, probiotic treatment of ulcerative colitis can avoid resistance and side effects of conventional treatment, but its mechanism of action is unknown. This study investigated the therapeutic effect and mechanism of action of potential probiotics Lactiplantibacillus plantarum HNU082 (Lp082) on dextran sulfate sodium-induced colitis in mice.Results: The results showed that the intake of Lp082 increased body weight, water intake, food intake, colon length, and reduced disease activity index, immune organ index, inflammatory markers, and histopathological score. Lp082 strengthened the biological barrier by improving the diversity and composition of gut microbiota, increasing the short chain fatty acids (SCFAs) producing bacteria and SCFAs content, and enhancing the metabolic pathway of SCFAs. Lp082 improved the chemical barrier by increasing the goblet cells and mucin-2 and decreasing the ICAM-1 and VCAM. Lp082 enhanced the mechanical barrier by increasing the mRNA expression of ZO-1, ZO-2, occludin and decreasing claudin-1 and claudin-2. Lp082 strengthened the immune barrier by reducing the content of IL-1β, IL-6, TNF-α, MPO, IFN-γ and increasing the IL-10, TGF-β1, and TGF-β2. Lp082 also affected gene expression in mice, including that it inhibited the gene expression of IL-1β, IL-1α, Ereg, Cdc7, and others. Thus inhibited the biological processes such as IL-1β production, IL-6 production, acute inflammatory response, and promoted the expression of genes Isg15, Prg2, Abcc2, thus boosting the biological processes such as IL-10 production and drug transport. The differentially expressed genes in DSS group were primarily enriched in the disease-related KEGG pathways but were mainly enriched in the KEGG pathway associated with platelet activated autophagy in animals in Lp082 group. Lp082 also inhibited the mRNA expression of NF-κB1, NF-κB2, COX-2, iNOS, Toll-4, and others, thus suppressing the NK-KB pathways.Conclusions: Shotgun metagenomic and transcriptome analysis revealed that Lp082 could relieve ulcerative colitis, protect the intestinal mucosal barrier through SCFAs, regulate gene expression and signaling pathways. The study provides new clues to reveal the complex mechanisms of the gut barriers and genes in relieving ulcerative colitis.

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Section: Discussionsupporting

confidence: 51%

Probiotics (Lactiplantibacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related genes expression, gut microbiota, and metabolic pathways in mice

Jha

et al. 2022

Preprint

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“…Among the typical bacterial groups in mice fed BW, besides lactic acid bacteria, Clostridia _UCG-014 and Roseburia are associated with beneficial properties, such as anti-inflammatory and anti-obesity effects ( Kasahara et al, 2018 , Quan et al, 2018 , Yang et al, 2021 ). T. sanguinis might be important for host lipid and steroid metabolism ( Hoffman and Margolis, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Detection and isolation of typical gut indigenous bacteria in ICR mice fed wheat bran and wheat straw fibre

Takei

Kuda

Handa

et al. 2022

Food Chemistry: Molecular Sciences

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“…These processes are essential to maintain gut microbiota that depends mostly on non-digestively polysaccharides and fibers as energy sources ( Sonnenburg and Sonnenburg, 2014 ). In turn, notably, polysaccharides are primary modulators of the function and composition of gut microbiota ( Sonnenburg and Backhed, 2016 ; Yang et al, 2021a ). Importantly, accumulating evidence demonstrates that supplementation of natural polysaccharides is an effective gut-microbiota-targeted treatment for HFD-induced metabolic disorders ( Wang et al, 2018a ; Su et al, 2021 ).…”

Section: Supplementation Of Natural Polysaccharides Ameliorate Hfd-in...mentioning

confidence: 99%

Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases

et al. 2022

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Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worldwide. Evidence is accumulating that the gut microbiota is inextricably associated with HFD-induced metabolic disorders, and dietary intervention of gut microbiota is an effective therapeutic strategy for these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber that exhibit biological activities in the prevention and treatment of HFD-induced metabolic diseases. Of note, natural polysaccharides are among the most potent modulators of the gut microbiota composition. However, the prebiotics-like effects of polysaccharides in treating HFD-induced metabolic diseases remain elusive. In this review, we introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders. Importantly, we review current knowledge about the role of natural polysaccharides in improving HFD-induced metabolic diseases by regulating gut microbiota.

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Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis

Abstract: Gut barrier dysfunction is triggered by gut microbiota dysbiosis that is closely associated with ulcerative colitis. Here, we first studied the prophylactic capacity of turmeric polysaccharides (TPS) to ameliorate dextran...

Cited by 68 publications

References 53 publications

Probiotics (Lactiplantibacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related genes expression, gut microbiota, and metabolic pathways in mice

Probiotics (Lactiplantibacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related genes expression, gut microbiota, and metabolic pathways in mice

Detection and isolation of typical gut indigenous bacteria in ICR mice fed wheat bran and wheat straw fibre

Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases

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