Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study

Valentini, Francesco; Evangelisti, Melania; Arpinelli, Marta; Nardo, Giovanni Di; Borro, Marina; Simmaco, Maurizio; Villa, Maria Pia

doi:10.1016/j.sleep.2020.10.017

Cited by 50 publications

(33 citation statements)

References 52 publications

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“…Recent research demonstrated that Oscillospiraceae could induce inflammatory response in mice. 34 Our results showed that the relative abundance of Oscillospiraceae in feces was significantly positively correlated with IL-1⊎ level in serum of piglets. In conclusion, supplementation of 25OHD 3 in low Ca-P diet could improvethe immune function of piglets by regulating the structure of intestinal microbiota, and our study suggested that changes in intestinal microbiota induced by 25OHD 3 may be associated with bone quality of piglets.…”

Section: Discussionmentioning

confidence: 50%

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

2021

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BACKGROUND: With the development of intensive farming, long-term exposure of pigs to poor light conditions is not conducive to the production of vitamin D 3 , and vitamin D 3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25-Hydroxyvitamin D 3 (25OHD 3 ) has higher bioactivity than regular vitamin D 3 . This study investigated the effects of 25OHD 3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca-P diet.RESULTS: It was found that a low Ca-P diet supplemented with 50 ∼g/kg 25OHD 3 (NC + 25-D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone-specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca-P diet (NC), but no differences were observed between a normal Ca-P diet (PC) and the NC + 25-D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25-D. NC + 25-D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD 3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).CONCLUSION: Supplementation of 25OHD 3 in a low Ca-P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca-P diet.

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Section: Discussionmentioning

confidence: 50%

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

2021

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“…For example, Helicobacter and Oscillospiraceae as well as dramatically increased Desulfovibrio have been reported to stimulate inflammation. 34–36…”

Section: Resultsmentioning

confidence: 99%

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

et al. 2022

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“…An important anaerobic genus, Bacteroides , are responsible for breaking down polysaccharides in the gut ecosystem [ 61 ]. Oscillospiraceae_UCG-002 , Oscillospira , and Dielma significantly enriched the gut of hens in the highest density, which might be an unfavourable signal because they pose a threat to host health [ 62 – 64 ]. Because of the alteration of the microbiome, the in vivo findings revealed that the oral administration of Bifidobacterium might induce cancer immunotherapy [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…When considering the two driven factors (stocking density and age), it was found that the gut of laying hens with the highest density (BL vs. BH) and the younger (AL vs. BL and AH vs. BH) was significantly enriched with one phylum (Bdellovibrionota) and two genera ( Eisenbergiella and Lachnoclostridium ), wherease Oscillospiraceae_UCG-002 and Erysipelotrichaceae_UCG-003 had the opposite trend. The increased proportion of inflammation-related bacterium ( Oscillospiraceae ) and Erysipelotrichaceae_UCG-003 were linked to the sub-health status in the host [ 62 , 81 ]. Xie et al [ 71 ] documented that Lachnoclostridium had a crucial role in response to variations in intestinal proteins, while Eisenbergiella was reported to be connected with weight gain in humans [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of stocking density and age on physiological performance and dynamic gut bacterial and fungal communities in Langya hens

Jin

Zhang

Li³

et al. 2021

Microb Cell Fact

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Background The characterization of colonization and dynamic changes related to gut microorganisms might be vital, as it presents an opportunity to quantify the co-variation between stocking densities and gut microbiome of dynamic distribution. The objective of this study was to determine the stocking density on physiological performance and dynamic distribution of gut microbiome (including bacterial and fungal communities) of Langya laying hens in the two development stages. Methods A randomized design with 2 × 3 factorial controls consisting of two development stages (24, 43 weeks-old) with three different stocking densities was performed. Three different stocking densities were allocated to a total of 300 11-week-old Langya laying hens (450 cm2/bird, 675 cm2/bird, 900 cm2/bird). Three housing densities were accomplished by raising different chickens per cage with the same floor size. The dependent variables of stocking densities at each sampling point were; growth performance, organs index, egg quality and the changes of dynamic gut bacterial and fungal communities in the cecum. Results Results showed that the stocking density didn’t affect liver index, eggshell thickness, breaking shell strength and egg shape index. Hens from the highest stocking density had the lowest body weight, fallopian tube index, egg weight and yolk colour score. Except for the yolk colour score, the measurement changes caused by age followed the opposite pattern as stocking density. We observed a substantial rise in taxa linked with health threats when stocking density was increased, including Talaromyces, Oscillospiraceae_UCG-002, Oscillospira, and Dielma. The opposite was observed with Bacteroides, Bifidobacterium, Lachnoclostridium, Eisenbergiella, and Kurtzmaniella. Also, most taxa were linked to polymicrobial infection in clinical cases, especially species whose percentage declined as the hens aged, such as Terrisporobacter, Faecalicoccus, Dialister, Cylindrocarpon etc. Whereas Sellimonas, Mitsuokella, Eurotium, Wardomyces and Cephalotheca had the opposite trend. Conclusion We speculated that excessive high density drove the abundance of bacteria and fungi connected with health problems. Where the gut microecology gradually reach a mature and balance status with age. Overall, this study demonstrates gut microbiome ecological processes in Langya layers at various stocking densities and finds possible connections between stocking density, microbiome and production performance. Our study will contribute to new insights associating suitable density patterns and production performance in laying hens by harnessing such a relative microbiome.

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Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study

Cited by 50 publications

References 52 publications

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Effect of stocking density and age on physiological performance and dynamic gut bacterial and fungal communities in Langya hens

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Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study

Cited by 50 publications

References 52 publications

Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice

Effect of stocking density and age on physiological performance and dynamic gut bacterial and fungal communities in Langya hens

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Product

Resources

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Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus