Gut Microbiota and Serum Biomarker Analyses in Obese Patients Diagnosed with Diabetes and Hypothyroid Disorder

Tabasi, Mohsen; Eybpoosh, Sana; Heravi, Fatemah Sadeghpour; Siadat, Seyed Davar; Mousavian, Ghazal; Elyasinia, Fezzeh; Soroush, Ahmadreza

doi:10.1089/met.2020.0119

Cited by 14 publications

(12 citation statements)

References 29 publications

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“…We found consistent evidence for reduced abundances of F. prausnitzii (37)(38)(39)(40)(41)(42), C. leptum group (42,48,58,59), and Oscillospiraceae (45,60) with elevated insulin concentrations and insulin resistance (Table 2, Figure 4). This included 2 studies…”

Section: F Prausnitzii C Leptum Group Faecalibacterium and Oscillospi...supporting

confidence: 64%

“…The abundance of A. muciniphila was inversely associated with fasting glucose and HbA1c (45-49) and with insulin concentrations and insulin resistance (46)(47)(48)50) and was lower in treatment-naïve individuals with prediabetes than in normoglycemic controls (45,51) (Tables 1 and 2, Figures 3 and 4). Inverse associations were also found for the genus level (52,53), where the association between Akkermansia and fasting glucose withstood statistical correction for metabolic disease diagnosis, use of metabolic drugs, as well as sex, age, and lifestyle factors (52) (Table 1, Figure 3).…”

Section: A Muciniphila and Akkermansiamentioning

confidence: 99%

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The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

Palmnäs-Bédard

Costabile

Vetrani

et al. 2022

The American Journal of Clinical Nutrition

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The gut microbiota plays a fundamental role in human nutrition and metabolism and may have direct implications for type 2 diabetes and associated pre-conditions. An improved understanding of relationships between human gut microbiota and glucose metabolism could lead to novel opportunities for type 2 diabetes prevention, but human observational studies reporting on such findings have not been extensively reviewed. Here, we review the literature on associations between gut microbiota and markers and stages of glucose dysregulation and insulin resistance in healthy adults and in adults with metabolic disease and risk factors. We present the current evidence for identified key bacteria and their potential roles in glucose metabolism independently of overweight, obesity and metabolic drugs. We provide support for short-chain fatty acids (SCFA) mediating such effects and discuss the role of diet and gut microbiota x diet derived metabolites. From 5983 initially identified PubMed records, 45 original studies were eligible and reviewed. Alpha diversity and 45 bacterial taxa were associated with selected outcomes. Six taxa were most frequently associated with glucose metabolism: Akkermansia muciniphila, Bifidobacterium longum, Clostridium leptum group, Faecalibacterium prausnitzii and Faecalibacterium (inversely associated) and Dorea (directly associated). For Dorea and A. muciniphila, associations were independent of metabolic drugs and body measures. For A. muciniphila and F. prausnitzii, limited evidence supported SCFA-mediation of potential effects on glucose metabolism. We conclude that observational studies applying metagenomics sequencing to identify species-level relationships are warranted, as are studies accounting for confounding factors and investigating SCFA and postprandial glucose metabolism. Such advances in the field will, together with mechanistic and prospective studies and investigations into diet-gut microbiota interactions, have the potential to bring critical insight into roles of gut microbiota and microbial metabolites in human glucose metabolism and to contribute towards the development of novel prevention strategies for type 2 diabetes, including precision nutrition.

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Section: F Prausnitzii C Leptum Group Faecalibacterium and Oscillospi...supporting

confidence: 64%

Section: A Muciniphila and Akkermansiamentioning

confidence: 99%

The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

Palmnäs-Bédard

Costabile

Vetrani

et al. 2022

The American Journal of Clinical Nutrition

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“…e intestinal microbial genome is considered as the second largest genome in the human body, and its relationship with diseases has always been a research hotspot. In recent years, studies have shown that intestinal microecology is closely related to many diseases, including rectal cancer, pancreatic cancer, type 2 diabetes, depression, Parkinson's disease, and cardiovascular disease [14][15][16]. On the other hand, some intestinal microorganisms play many beneficial roles, including immune system development, reaction or tolerance, participation in carbohydrate digestion, and toxic substance degradation.…”

Section: Introductionmentioning

confidence: 99%

Explore and Analyze the Composition and Characteristics of Intestinal Microbiota between Gastric Cancer Patients and Healthy People

Wang

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Gastric cancer is one of the most common malignant tumors in the world. As the intestine is downstream of the digestive tract, the occurrence of gastric cancer may have a certain significant impact on it. Therefore, it is particularly important to find out the intestinal bacteria closely related to gastric cancer, to identify the specific flora related to gastric cancer, and to maintain the stability of the core structure of intestinal microecology in patients with gastric cancer. Based on this, the fecal samples of gastric cancer patients and healthy people were collected, and the diversity and composition of intestinal flora in patients with gastric cancer were analyzed by 16S rRNA sequencing technology. We found that there was no significant difference in the diversity and abundance of intestinal flora between gastric cancer patients and healthy people. The relative abundance of Faecalibacterium, Bifidobacterium, and Subdoligranulum in the intestinal tract of patients with gastric cancer was significantly lower than that in healthy people, while the relative abundance of Enterococcus, Streptococcus, and Bacteroides was increased. This study found that there were six kinds of intestinal microflora closely related to the occurrence of gastric cancer, which provided a theoretical basis for further exploring the pathogenesis of gastric cancer.

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“…Overweight and obesity are serious public health problems resulting from combination factors such as of genetic, metabolic, behavioral, environmental, and cultural [1][2][3]. According to the recent estimates, the incidence of obesity has increased significantly [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Helicobacter pylori Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

Farsimadan¹,

Heravi²,

Emamvirdizadeh³

et al. 2021

Dig Dis

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Introduction: Obesity is a well-known risk factor for a variety of gastrointestinal disorders (GID). Helicobacter pylori is associated with different GID, such as gastric cancer and chronic gastritis. In this study, we investigated the prevalence of dominant genotypes in H. pylori isolated from obese patients diagnosed with gastric ulcer, duodenal ulcer, and gastric cancer. Methods: A total of 222 H. pylori-positive samples were collected from patients with obesity. GID and gastric cancer were identified by endoscopy and histopathology, respectively. Three biopsy specimens from the gastric antrum were obtained from each patient for culture tests, histological examination, and identification of vacuolating cytotoxin A (vacA) (vacA s1, vacA s2, vacA m1, vacA m2, vacA s1m1 vacA s1m2, vacA s2m1, and vacA s2m2), cagA, cagE, iceA1, oipA, dupA, and babA2 using polymerase chain reaction. Results: vacA, cagE, cagA, iceA1, oipA, dupA, and babA2 genes were detected in 222 (100%), 171 (77%), 161 (72.5%), 77 (34.6%), 77 (34.6%), 137 (61%), and 69 (31%) patients with obesity, respectively. Our findings revealed that vacA, iceA1, oipA, and babA2 were significantly associated with a higher risk of GID, while cagE, cagA, and dupA indicated no correlation with the development of GID. Also, in the combination of s- and m-region genotypes, s1m2 (79%) was the most frequently identified genotype in patients with obesity. A significant association was also found between cagA and the presence of vacA genotypes (except for vacA m1 and babA2). Conclusions: This study indicated the high prevalence of different virulence genes in H. pylori isolated from obese patients and supported the significant role of H. pylori in the development of GID.

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Gut Microbiota and Serum Biomarker Analyses in Obese Patients Diagnosed with Diabetes and Hypothyroid Disorder

Cited by 14 publications

References 29 publications

The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

Explore and Analyze the Composition and Characteristics of Intestinal Microbiota between Gastric Cancer Patients and Healthy People

Evaluation of <b><i>Helicobacter pylori</i></b> Genotypes in Obese Patients with Gastric Ulcer, Duodenal Ulcer, and Gastric Cancer: An Observational Study

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