Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

Biver, Emmanuel; Bérenbaum, Francis; Valdes, Ana; Carvalho, Islène Araujo de; Bindels, Laure B.; Brandi, Maria Luisa; Calder, Philip C.; Castronovo, Vincenzo; Cavalier, Étienne; Cherubini, Antonio; Cooper, Cyrus; Dennison, Elaine; Franceschi, Claudio; Fuggle, Nicholas R; Laslop, Andrea; Miossec, Pierre; Thomas, Thierry; Tüzün, Şansın; Veronese, Nicola; Vlaskovska, Mila; Reginster, Jean Yves; Rizzoli, René

doi:10.1016/j.arr.2019.100946

Cited by 108 publications

(75 citation statements)

References 85 publications

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“…Thus, considering these proinflammatory effects, obesity is considered one of the main risk factors of OA [60], and it seems to also negatively influence muscle mass and function in older people [61,62]. In animal models, a high-fat/high-sucrose diet is able to promote knee joint damage, with an increase of the intestinal permeability and a consequent increase of serum levels of LPS, supporting the hypothesis of a linkage between gut dysbiosis, metabolic inflammation, and OA [7].…”

Section: Obesity and Metabolic Syndromementioning

confidence: 81%

“…Moreover, it has recently been shown that the subchondral dysbiosis resulting from the bacterial translocation from GM to the joint, might support the development of OA [14]. Therefore, considering gut dysbiosis and the leaky gut syndrome as cofactors in the development of inflammaging and consequently of OA [38], it is likely to hypothesize the existence of a 'gut-joint axis' [7,[14][15][16]].…”

Section: Inflammagingmentioning

confidence: 99%

“…The etiology of OA still remains unknown, but several risk factors have been identified such as age, sex, obesity, diet, physical inactivity, abnormal loading of the joints, metabolic syndrome, and inflammaging [6]. These two latter conditions are key components of OA onset and evolution, and recently the microbial dysbiosis induced by quantitative and qualitative alterations of the gut microbiota (GM) has been shown to sustain a chronic systemic low-grade inflammation, boosting the main pathophysiological mechanisms underpinning OA [7].…”

Section: Introductionmentioning

confidence: 99%

“…Modifications in the GM composition and metabolic activity might alter the immune response and host metabolism, leading to a constant low-grade inflammation status with consequent development of musculoskeletal impairment and frailty [12,13]. Furthermore, an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases has recently hypothesized that GM is a major hidden risk factor for OA [7].…”

Section: Introductionmentioning

confidence: 99%

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Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Sire

Petito

et al. 2020

Nutrients

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Osteoarthritis (OA) is considered one of the most common joint disorders worldwide and its prevalence is constantly increasing due to the global longevity and changes in eating habits and lifestyle. In this context, the role of gut microbiota (GM) in the pathogenesis of OA is still unclear. Perturbation of GM biodiversity and function, defined as ‘gut dysbiosis’, might be involved in the development of inflammaging, one of the main risk factors of OA development. It is well known that physical exercise could play a key role in the prevention and treatment of several chronic diseases including OA, and it is recommended by several guidelines as a first line intervention. Several studies have shown that physical exercise could modulate GM composition, boosting intestinal mucosal immunity, increasing the Bacteroidetes–Firmicutes ratio, modifying the bile acid profile, and improving the production of short chain fatty acids. Moreover, it has been shown that low intensity exercise might reduce the risk of gastrointestinal diseases, confirming the hypothesis of a strict correlation between skeletal muscle and GM. However, up to date, there is still a lack of clinical trials focusing on this research field. Therefore, in this narrative, we aimed to summarize the state-of-the-art of the literature regarding the correlation between these conditions, supporting the hypothesis of a ‘gut–joint axis’ and highlighting the role of physical exercise combined with adequate diet and probiotic supplements in rebalancing microbial dysbiosis.

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Section: Obesity and Metabolic Syndromementioning

confidence: 81%

Section: Inflammagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Sire

Petito

et al. 2020

Nutrients

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“…Therefore, Faecalibacterium can regulate bone metabolism by producing butyric acid, promote bone formation, and inhibit bone resorption. In addition, studies have shown that inflammatory cytokines produced by activated T cells can increase osteoclast activity and lead to bone resorption in autoimmune diseases such as rheumatoid arthritis (Biver et al, 2019). Faecalibacterium has anti-inflammatory properties, which can induce the increase of anti-inflammatory cytokine IL-10 and other cytokines, thus inhibiting bone resorption (Miquel et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Reveals Specific Dysbiosis in Primary Osteoporosis

Xie

Sun

et al. 2020

Front. Cell. Infect. Microbiol.

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Object: Primary osteoporosis (PO) is the most common bone disease, which is characterized by decreased bone mass, damage of bone tissue microstructure, increased bone fragility, and is prone to fracture. Gut microbiome may be involved in bone metabolism of PO through gut-brain axis regulation of immune system and endocrine system, however, the specific mechanism is still unclear. The purpose of this study was to characterize the gut microbiome of patients with PO and its possible role in the occurrence and development of the disease. Methods: Fecal samples were collected from 48 PO patients and 48 healthy controls (HC). The composition of gut microbiome community was analyzed by 16s rDNA amplification sequencing, and the difference of gut microbiome composition between PO patients and HC individuals was compared. PICRUSt was also used to predict the biological function of gut microbiome in patients with PO, and to explore its possible role in the occurrence and development of this disease. The classification model is constructed by random forest algorithm so as to screen the key biomarkers. Result: The diversity of gut microorganisms in PO patients was significantly higher than that in HC group (p < 0.05) and there was significant difference in microbial composition in PO group. The abundance of Dialister (0.036 vs. 0.004, p < 0.001) and Faecalibacterium (0.331 vs. 0.132, p < 0.001) were significantly enriched which were the key flora related to PO. Although no significant correlation between bone mineral density and the richness of microbial communities are found, PICRUST results show that there are a wide range of potential pathways between gut microbiome and PO patients, including genetic information processing, metabolism, environmental information processing, cellular processes, human diseases, and organic systems. Notably, the discriminant model based on dominant microflora can effectively distinguish PO from HC (AUC = 93.56). Conclusions: The findings show that PO is related to the change of gut microbiome, especially the enriched Dialister and Faecalibacterium genera, which give new clues to understand the disease and provide markers for the diagnosis and new strategies for intervention treatment of the disease.

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Clinical pain management in the rheumatic diseases

Minerbi

Fitzcharles

2022

Clinical Pain Management

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Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

Cited by 108 publications

References 85 publications

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Gut Microbiome Reveals Specific Dysbiosis in Primary Osteoporosis

Clinical pain management in the rheumatic diseases

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