Gut Microbiota and Cancer Correlates

Malaviya, Alok; Paari, Kuppusamy Alagesan; Malviya, Shruti; Kondapalli, Vamsi Krishna; Ghosh, Aditi; Samuel, Riya Ann

doi:10.1007/978-981-15-8214-1_1

Cited by 2 publications

(3 citation statements)

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“…Lactobacillus revealed its anticancer efficiency by releasing nitric oxide responsible for suppressing metabolic pathways in cancer cells and previously has shown a vital role in cervical cancers and the ability to induce an auto-aggregation mechanism that impedes the adhesion of pathogens to vaginal epithelial cells [71]. One representative (L. casei) showed to trigger apoptosis and inhibit the tumoral growth via the secretion of a tumor-suppressive cyclic hexapeptide ferrichrome [5]. Literature indicates that the main probiotics that might be involved in the prevention of colon cancer are L. rhamnosus, L. kefiri, L. salivarius, L. acidophilus, L. plantarum, L. delbrueckii, L. casei, B. longum, B. infantis, B. bifidum, B. brevis, E. coli Nissle 1917, and S. thermophilus [5].…”

Section: Preclinical Effectmentioning

confidence: 99%

“…One representative (L. casei) showed to trigger apoptosis and inhibit the tumoral growth via the secretion of a tumor-suppressive cyclic hexapeptide ferrichrome [5]. Literature indicates that the main probiotics that might be involved in the prevention of colon cancer are L. rhamnosus, L. kefiri, L. salivarius, L. acidophilus, L. plantarum, L. delbrueckii, L. casei, B. longum, B. infantis, B. bifidum, B. brevis, E. coli Nissle 1917, and S. thermophilus [5]. Additionally, the probiotic supplementation with Clostridium butyricum reduced the systemic inflammatory responses, alleviated the chemotherapy-induced diarrheal episodes, and sustained the intestinal microbiota in lung cancer patients [72].…”

Section: Preclinical Effectmentioning

confidence: 99%

“…Many reviews have been published in the last decades discussing the effect of probiotics in counteracting bacterial infections (e.g., Campylobacter jejuni , Salmonella enteritidis , Clostridium perfringens , Escherichia coli , Shigella spp., Listeria spp., etc. ), especially from intestinal microbiota level [ 5 , 6 , 7 ]. From these considerations, probiotic bacteria secrete different inhibitory peptides, organic acids, peroxides, including other small-weigh molecules with exceptional anti-bacterial, anti-viral, anticancer, anti-inflammatory activity [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Novel Insights into the Role of Probiotics in Respiratory Infections, Allergies, Cancer, and Neurological Abnormalities

et al. 2021

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In recent years, probiotics have attracted public attention and transformed the social perception of microorganisms, convening a beneficial role/state on human health. With aging, the immune system, body physiology, and intestinal microbiota tend to change unfavorably, resulting in many chronic conditions. The immune-mediated disorders can be linked to intestinal dysbiosis, consequently leading to immune dysfunctions and a cluster of conditions such as asthma, autoimmune diseases, eczema, and various allergies. Probiotic bacteria such as Lactobacillus and Bifidobacterium species are considered probiotic species that have a great immunomodulatory and anti-allergic effect. Moreover, recent scientific and clinical data illustrate that probiotics can regulate the immune system, exert anti-viral and anti-tumoral activity, and shields the host against oxidative stress. Additionally, microbiota programming by probiotic bacteria can reduce and prevent the symptoms of respiratory infections and ameliorate the neurological status in humans. This review describes the most recent clinical findings, including safe probiotic therapies aiming to medicate respiratory infections, allergies, cancer, and neurological disorders due to their physiological interconnection. Subsequently, we will describe the major biological mechanism by which probiotic bacteriotherapy expresses its anti-viral, anti-allergic, anticancer, and neuro-stimulatory effects.

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Section: Preclinical Effectmentioning

confidence: 99%