Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy

Gondalia, Shakuntla; Parkinson, Lisa; Stough, Con; Scholey, Andrew

doi:10.1007/s00213-019-05248-6

Cited by 42 publications

(29 citation statements)

References 113 publications

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“…The most recent data indicates that gastrointestinal homeostasis significantly affects the development and functioning of the central nervous system, which presents the so-called microbiota-gut-brain axis as the new paradigm in neuroscience [151]. Neuropsychiatric disorders where the etiopathology can be related to the gastrointestinal microbiota include anxiety, autism, anorexia nervosa, Parkinson's disease, Alzheimer's disease, ADHD, schizophrenia, alcohol dependence, bipolar disorders, or migraine pain [82,100,[152][153][154][155][156][157][158][159][160][161]. Interestingly, the microbiota-gut-brain axis starts to develop during the intrauterine period of fetal development.…”

Section: The Impact Of Gut Microbiota On the Cnsmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the nervous system and gut microbiota, genetics, and the available treatment for PANDAS. Recent research indicates that PANDAS patients show noticeable alterations within the structures of the central nervous system, including caudate, putamen, globus pallidus, and striatum, as well as bilateral and lentiform nuclei. Likewise, the presence of autoantibodies that interact with basal ganglia was observed in PANDAS patients. Several studies also suggest a relationship between the presence of obsessive-compulsive disorders like PANDAS and alterations to the gut microbiota. Further, genetic predispositions—including variations in the MBL gene and TNF-α—seem to be relevant regarding PANDAS syndrome. Even though the literature is still scarce, the authors have attempted to provide a thorough insight into the PANDAS syndrome, bearing in mind the diagnostic difficulties of this condition.

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Section: The Impact Of Gut Microbiota On the Cnsmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

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show abstract

“…Interestingly, accumulating data indicated that the gastrointestinal (GI) microbiota could in uence brain functions, mood symptoms and behaviors. Gut microbiota dysbiosis was observed in individuals with mood disorders such as autism, bipolar disorder [20], anxiety and depression. Therefore, it may be a novel way to explore the gut-brain axis to assist and/or strengthen the effectiveness of psychopharmacology and psychotherapy, such as the mindfulness based interventions.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, following a fecal microbiota transplant (FMT) from participants with MDD patients, the depressive-like behaviors was also transferred to germ-free mice. In another animal study, it was found enhanced physiological response to stress among germ-free mice compared to pathogen-free mice, and the altered stress response could be partially corrected if GI microbiota were reconstituted at an early age [20]. Furthermore, the consumption of probiotics was demonstrated to place a positive impact on alleviating stress responses, symptoms of anxiety and depression, and cognitive functions in both clinical studies [23][24][25] and in animal studies [26].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Associated with Effectiveness and Responsiveness to Mindfulness-Based Cognitive Therapy in Improving Trait Anxiety

wang

Liu

et al. 2021

Preprint

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ObjectiveThe mindfulness based interventions have been widely demonstrated effective on reducing stress, alleviating mood disorders and improving quality of life; however, the underlying mechanisms remained to be fully understood. Along with the advanced research in microbiota-gut-brain axis, this study aimed to explore the impact of gut microbiota on the effectiveness and responsiveness to mindfulness-based cognitive therapy (MBCT) among high trait anxiety populations.DesignA standard mindfulness-based cognitive therapy (MBCT) was performed among 21 young adults with high trait anxiety. A total of 29 healthy controls were matched for age and sex. The differences on gut microbiota between the two groups were compared. The changes of fecal microbiota and psychological indicators were also investigated before and after the intervention. ResultsCompared with healthy controls, we found markedly decreased bacterial diversity and distinctive clusters among high trait-anxiety populations, with significant overgrowth of bacteria such as Streptococcus, Blautia, Romboutsia, and decrease of genera such as Faecalibacterium, Coprococcus_3, Lachnoclostridium. Moreover, MBCT attenuated trait-anxiety and depression, improved mindfulness and resilience, and turned gut microbiota more close to that of healthy controls. Notably, high burden of intestinal Subdoligranulum pre-MBCT was associated with an increased responsiveness to MBCT. Decreases in Subdoligranulum post-MBCT were indicative of ameliorated trait anxiety. The tryptophan metabolism pathways were significantly over-represented among high-responders compared to low-responders.Conclusion The significantly increased diversity post-MBCT added evidence to gut-brain communication, and highlighted the utility of mycobiota-focused strategies for promoting effectiveness and responsiveness of the MBCT to improve trait anxiety.Trial registration: Chictr.org.cn, ChiCTR1900028389. Registered 20 December 2019, http://www.chictr.org.cn/edit.aspx?pid=47167&htm=4

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“…Several studies have investigated the microbiome composition in patients with bipolar disorder. The first published study involved 115 patients and reported decreased levels of Faecalibacterium.…”

mentioning

confidence: 99%

Gut microbiota: a missing link in psychiatry

Dinan

Cryan

2020

World Psychiatry

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Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy

Cited by 42 publications

References 113 publications

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Gut Microbiota Associated with Effectiveness and Responsiveness to Mindfulness-Based Cognitive Therapy in Improving Trait Anxiety

Gut microbiota: a missing link in psychiatry

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