Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism

Rong, Bohan; Xia, Tianyu; Zhang, Tiantian; Feng, Ru; Huang, Hongtao; Wu, Qiong; Sun, Cheng

doi:10.1016/j.jnutbio.2018.10.020

Cited by 49 publications

(39 citation statements)

References 155 publications

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“…NAFLD and obesity are associated with higher gut barrier permeability, causing metabolic endotoxemia and an increase in the blood levels of LPS. Subsequently, it also causes hepatic and systemic inflammation as well as alterations in gene expression, hormone secretion, and energy consumption in distal peripheral tissues, such as the white adipose tissue [27]. This LPS role was corroborated in a preclinical study in which mice injected with LPS showed a similar phenotype than those obtained after a high fat diet (body weight gain, IR and increased NAFLD progression) [15].…”

Section: Role Of Lps In Gut Microbiota Dysbiosismentioning

confidence: 80%

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Quesada-Vázquez

Aragonès

Bas

et al. 2020

Cells

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Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression.

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Section: Role Of Lps In Gut Microbiota Dysbiosismentioning

confidence: 80%

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Quesada-Vázquez

Aragonès

Bas

et al. 2020

Cells

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“…Recently, the gut microbiota (GM) has emerged as a new contributor to weight gain and immune/inflammatory system imbalances. This concept has been demonstrated through fecal transfer experiments using mice 21 or human 22 donors and germ-free mice recipients, and suggests that fecal GM may impact energy metabolism and immune cell activation in the AT (reviewed in 23 ). An increasing number of studies has further demonstrated that a nonnegligible proportion of obese subjects exhibit GM dysbiosis.…”

Section: Introductionmentioning

confidence: 99%

Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

et al. 2019

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Obesity is a chronic low-grade inflammatory disease (both at the systemic and adipose tissue level) that continues to rise worldwide. It is associated with an abundance of comorbidities, including type 2 diabetes (T2D). Bariatric surgery, which induces modifications of the intestinal tract, is to date the most successful treatment for obesity. Its use has dramatically increased in number as it enables both weight reduction and metabolic improvements, with 60% of patients even achieving diabetes remission. Several mechanisms are actually demonstrated to be involved in those clinical improvements. Importantly, both obesity and T2D share many phenotypic characteristics, including increased systemic and adipose tissue inflammation, as well as gut microbiota dysbiosis. These characteristics are deeply modulated after bariatric surgery. This review will specifically focus on the host metabolic changes induced by bariatric surgery in regards of the induced gut architectural changes, as well as on the modifications in the inflammatory tone and gut microbiota observed subsequently to bariatric surgery induced weight loss.

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“…Micro-organisms extract energy from foods that humans cannot digest, producing bioactive compounds such as short-chain fatty acids (SCFAs)-mainly acetate, propionate and butyrate-which supply energy to the intestinal epithelium and liver, providing~10% of the daily caloric requirement [213]. The microbiota regulates energy balance through different mechanisms: gut-brain axis control at both the level of intestinal nutrient-sensing mechanisms, as well as at the central nervous system integration sites; development of a low-grade chronic systemic and adipose inflammation together with abnormal gut permeability by an increased relative abundance of pathogenic bacteria; effects on the metabolism of bile acids, with the production of secondary bile acids activating thyroid hormones and oxygen consumption; and impaired secretion of gut peptides and hormones implicated in appetite regulation [214][215][216]. Alterations in gut-brain signaling can affect the regulation of food intake and SCFAs impact on the incretins and hormones implicated in energy homeostasis, such as glucagon-like-peptide 1, gastric inhibitory peptide, peptide YY, leptin and insulin [217].…”

Section: The Impact Of the Gut Microbiota On The Human Energy Balancementioning

confidence: 99%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

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The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

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Gut microbiota: a potential manipulator for host adipose tissue and energy metabolism

Cited by 49 publications

References 155 publications

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

A Critical Review on the Role of Food and Nutrition in the Energy Balance

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