Gut microbiome–serum metabolic profiles: insight into the hypoglycemic effect of <i>Porphyra haitanensis</i> glycoprotein on hyperglycemic mice

Ou, Yujia; Guo, Ye; Chen, M S; Lu, Xiaodan; Guo, Zebin; Zheng, Baodong

doi:10.1039/d3fo02040a

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…This included body weight loss, shortened colon, and colonic inflammation; the results are consistent with previous study [ 29 ]. All these features were the typical symptoms of a colitis patient [ 30 ]; in contrast, Raf treatment significantly improved body weight and rescued the loss in daily weight gain loss in DSS model mice. Histologically, Raf significantly alleviated the pathological damage caused by colitis, achieving a relatively intact colonic structure without evident erosion and ulcers.…”

Section: Discussionmentioning

confidence: 99%

Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway

Zhang,

Xue,

Cao

et al. 2024

Foods

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This study aimed to explore the protective effects of raffinose (Raf) against inflammatory bowel disease in mice with colitis. Mice were administered 100, 200, or 400 mg/kg Raf for 21 d, followed by drinking-water containing 3% dextran sulfate sodium salt (DSS) for 3 d. Thereafter, the phenotype, pathological lesions in the colon, cytokines levels, and gut microbiota were evaluated. Treatment with Raf reduced the severity of the pathological changes in the colon, mitigating the reduction in colon length. Following Raf intervention, serum levels of inflammatory cytokines (IL-2, IL-6, IL-1β, and TNF-α) tended to return to normal. These results suggest that the anti-inflammatory effects of Raf are associated with a reduction in TLR4–MyD88–NF-κB pathway expression in mouse colonic tissues. Analysis of gut microbiota abundance and its correlation with colitis parameters revealed that DSS-induced dysbiosis was partially mitigated by Raf. In conclusion, Raf exerts a protective effect in colitis by modulating the gut microbiota and TLR4-MyD88-NF-κB pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway

Zhang,

Xue,

Cao

et al. 2024

Foods

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show abstract

Recent progress in Porphyra haitanensis polysaccharides: Extraction, purification, structural insights, and their impact on gastrointestinal health and oxidative stress management

Cheong,

Liu,

Chen

et al. 2024

Food Chemistry: X

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Hypoglycemic peptide preparation from Bacillus subtilis fermented with Pyropia: Identification, molecular docking, and in vivo confirmation

Han,

Xu,

et al. 2025

Food Chemistry

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Gut microbiome–serum metabolic profiles: insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice

Abstract: The hypoglycemic activity of natural algal glycoproteins has attracted interest, but studies of their mechanism of regulating glucose metabolism are lacking. This study investigated the hypoglycemic activity of Porphyra haitanensis...

Cited by 5 publications

References 45 publications

Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway

Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4–MyD88–NF-κB Signaling Pathway

Recent progress in Porphyra haitanensis polysaccharides: Extraction, purification, structural insights, and their impact on gastrointestinal health and oxidative stress management

Hypoglycemic peptide preparation from Bacillus subtilis fermented with Pyropia: Identification, molecular docking, and in vivo confirmation

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