Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation

Huang, Airu; Ji, Ling; Li, Yamei; Li, Yufeng; Yu, Qian

doi:10.1016/j.intimp.2023.110126

Cited by 5 publications

(1 citation statement)

References 152 publications

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“…Genus Ruminococcaceae UCG005 may influence the stroke prognosis by the pathway of glucose and lipid metabolism. Furthermore, ample evidence shows that imbalance in GM contributes to the neuroinflammation and worse stroke outcomes (Huang et al, 2023 ; Park et al, 2023 ). An animal-based study found that maternal sleep deprivation (MSD) caused high expression of pro-inflammatory cytokines in offspring rats Moreover, pro-inflammatory cytokines were positively associated with Ruminococcaceae UCG005 (Yao et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Zhu,

Li,

Chu

et al. 2024

Front. Microbiol.

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BackgroundIncreasing research has implicated the possible effect of gut microbiota (GM) on the prognosis of ischemic stroke (IS). However, the precise causal relationship between GM and functional outcomes after IS remains unestablished.MethodsData on 211 GM taxa from the MiBioGen consortium and data on prognosis of IS from the Genetics of Ischemic Stroke Functional Outcome (GISCOME) network were utilized as summary-level data of exposure and outcome. Four kinds of Mendelian randomization (MR) methods were carried out to ascertain the causal effect of GM on functional outcomes following IS. A reverse MR analysis was performed on the positive taxa identified in the forward MR analysis to determine the direction of causation. In addition, we conducted a comparative MR analysis without adjusting the baseline National Institute of Health Stroke Scale (NIHSS) of post-stroke functional outcomes to enhance confidence of the results obtained in the main analysis.ResultsFour taxa were identified to be related to stroke prognosis in both main and comparative analyses. Specifically, genus Ruminococcaceae UCG005 and the Eubacterium oxidoreducens group showed significantly negative effects on stroke prognosis, while the genus Lachnospiraceae NK4A136 group and Lachnospiraceae UCG004 showed protective effects against stroke prognosis. The reverse MR analysis did not support a causal role of stroke prognosis in GM. No evidence of heterogeneity, horizontal pleiotropy, and outliers was found.ConclusionThis MR study provided evidence that genetically predicted GM had a causal link with post-stroke outcomes. Specific gut microbiota taxa associated with IS prognosis were identified, which may be helpful to clarify the pathogenesis of ischemic stroke and making treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Zhu,

Li,

Chu

et al. 2024

Front. Microbiol.

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Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7

Qian,

Chen,

Sun

et al. 2024

Mol Neurobiol

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Uncovering the characteristics of the gut microbiota in patients with ischemic stroke and hemorrhagic stroke

Chen,

Huang,

Zhou

et al. 2024

Sci Rep

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This study aimed to explore the gut microbiota characteristics of ischemic and hemorrhagic stroke patients. A case–control study was conducted, and high-throughput sequencing of the V4–V5 region of 16S rRNA was used to analyze the differences in gut microbiota. The results showed that Proteobacteria was significantly increased in the ischemic stroke group compared with the healthy control group, while Fusobacteria was significantly increased in the hemorrhagic stroke group. In the ischemic stroke group, Butyricimonas, Alloprevotella, and Escherichia were significantly more abundant than in the healthy control group. In the hemorrhagic stroke group, Atopobium, Hungatella, Eisenbergiella, Butyricimonas, Odonbacter, Lachnociostridium, Alistipes, Parabacteroides, and Fusobacterium were significantly more abundant than in the healthy control group. Additionally, Alloprevotella, Ruminococcus, and Prevotella were significantly more abundant in the ischemic stroke group than in the hemorrhagic stroke group. The gut microbiota of ischemic and hemorrhagic stroke patients has significant diversity characteristics. These results provide new theoretical basis for exploring the prevention and treatment of different types of stroke through gut microbiota research.

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Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation

Cited by 5 publications

References 152 publications

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Causal effects of gut microbiota on the prognosis of ischemic stroke: evidence from a bidirectional two-sample Mendelian randomization study

Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7

Uncovering the characteristics of the gut microbiota in patients with ischemic stroke and hemorrhagic stroke

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