Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

Gubatan, John; Boye, Theresa Louise; Temby, Michelle; Sojwal, Raoul S; Holman, Derek; Sinha, S.; Rogalla, Stephan; Nielsen, Ole Haagen

doi:10.3390/microorganisms10071371

Cited by 22 publications

(17 citation statements)

References 120 publications

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“…Therefore, compared with healthy people, the gut microflora of IBD patients is in a state of dysregulation ( 25 , 26 ), which is manifested by changes in the composition, diversity and stability of the microbiota ( 26 – 28 ). Beneficial or commensal bacteria (such as Bacteroidetes, Firmicutes, and Actinobacteria) are reduced in IBD patients, accompanied by increases in pathogenic species (such as Proteobacteria) ( 29 , 30 ). The ratio of potentially pathogenic microbes to beneficial commensal microbes appears to play a key role in the disease development ( 31 ).…”

Section: Gut Microflora and Inflammatory Bowel Diseasementioning

confidence: 99%

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

et al. 2022

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Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease that occurs in the intestinal tract. It is mainly divided into two subtypes, i.e., the Crohn’s disease (CD) and ulcerative colitis (UC). At present, its pathogenesis has not been fully elucidated, but it has been generally believed that the environment, immune disorders, genetic susceptibility, and intestinal microbes are the main factors for the disease pathogenesis. With the development of the sequencing technology, microbial factors have received more and more attention. The gut microbiota is in a state of precise balance with the host, in which the host immune system is tolerant to immunogenic antigens produced by gut commensal microbes. In IBD patients, changes in the balance between pathogenic microorganisms and commensal microbes lead to changes in the composition and diversity of gut microbes, and the balance between microorganisms and the host would be disrupted. This new state is defined as dysbiosis. It has been confirmed, in both clinical and experimental settings, that dysbiosis plays an important role in the occurrence and development of IBD, but the causal relationship between dysbiosis and inflammation has not been elucidated. On the other hand, as a classic research method for pathogen identification, the Koch’s postulates sets the standard for verifying the role of pathogens in disease. With the further acknowledgment of the disease pathogenesis, it is realized that the traditional Koch’s postulates is not applicable to the etiology research (determination) of infectious diseases. Thus, many researchers have carried out more comprehensive and complex elaboration of Koch’s postulates to help people better understand and explain disease pathogenesis through the improved Koch’s postulates. Therefore, focusing on the new perspective of the improved Koch’s postulates is of great significance for deeply understanding the relationship between dysbiosis and IBD. This article has reviewed the studies on dysbiosis in IBD, the use of microbial agents in the treatment of IBD, and their relationship to the modified Koch’s postulates.

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Section: Gut Microflora and Inflammatory Bowel Diseasementioning

confidence: 99%

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

et al. 2022

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“…Кроме того, показано, что повышение в микробиоте количества Bacteroides fragilis начиная с возраста 1 мес ассоциировано с более высоким индексом массы тела [15]. В последнее десятилетие расшифрованы характерные изменения микробиоты при воспалительных заболеваниях кишечника [16], целиакии [17], синдроме раздраженного кишечника [18], аллергических заболеваниях [19], ожирении [20,21], поэтому особую важность приобретают превентивные, в том числе диетологические, методы поддержания баланса между микробиотой и иммунными субстратами кишечного эпителия [22].…”

Section: каждый новый шаг на пути прогресса дает новую надежду и связ...unclassified

The Choice of Product for Mixed or Formula Feeding of Infant: Beneficial Properties of Goat’s Milk Formula

Belyaeva

Бомбардирова

Турти

2022

Vopr. sovr. pediatr.

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This review summarizes the benefits of goat’s milk as the basis to produce adapted milk formulas according to relevant infants feeding issues. The characteristics of main nutrients of modern goat’s milk formulas are presented. A balanced protein composition enriched with β-palmitate, presence of prebiotics-oligosaccharides, natural nucleotides and probiotics advances these formulas closer to breast milk and provide their multipotent sanogenetic effects. The unique composition of goat’s milk formulas allows to ensure normal physical growth of a baby, induces tissue and systemic immunity via adequate intestinal microbiota formation, maintains normal functioning of gut-brain axis, that promotes vegetative and visceral disorders (due to functional digestive disorders) correction. Thus, it is possible to recommend goat’s milk formulas in cases of forced mixed or formula feeding of healthy infants and children with functional digestive disorders.

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“…Although the pathogenesis of IBD is still an evolving area of research, it is thought to involve environmental, genetic and immunological factors that coalesce to produce a heightened inflammatory reaction in the intestinal mucosa. More recent data have contributed to the emerging role of the gut microbiome in influencing IBD development and progression 4 …”

Section: Introductionmentioning

confidence: 99%

Gut microbiome–based therapeutics in inflammatory bowel disease

Gubatan

2023

Clinical and Translational Dis

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Gut microbiome dysbiosis is a recognized critical factor in IBD pathogenesis.• Therapeutic strategies that contribute to the restoration of gut microbial homeostasis have been studied in IBD which includes antibiotics, pre-/pro-/synbiotics and faecal microbiota transplant (FMT).• Gut microbiome-based therapeutics have been reported to have some benefits in IBD, such as improving symptoms, attenuating mucosal inflammation, and increasing rates of clinical remission.

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Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

Cited by 22 publications

References 120 publications

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

Investigating dysbiosis and microbial treatment strategies in inflammatory bowel disease based on two modified Koch’s postulates

The Choice of Product for Mixed or Formula Feeding of Infant: Beneficial Properties of Goat’s Milk Formula

Gut microbiome–based therapeutics in inflammatory bowel disease

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