Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

Belizário, José Ernesto; Faintuch, Joel; Garay-Malpartida, Humberto Miguel

doi:10.1155/2018/2037838

Cited by 212 publications

(145 citation statements)

References 99 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Significant evidence supports the relationship between the gut microbiome, inflammation, host response, and health (Pedersen et al, 2016;Dinan and Cryan, 2017;Kelly et al, 2017;Giron and Quigley, 2018). Disruption of the microbiome can lead to changes in microbial metabolism and consequently host metabolism (Belizario et al, 2018). The aforementioned changes can also affect inflammatory responses and adaptive immunity and can even contribute to metabolic disorders (Belizario et al, 2018).…”

Section: Introductionmentioning

confidence: 98%

“…Disruption of the microbiome can lead to changes in microbial metabolism and consequently host metabolism (Belizario et al, 2018). The aforementioned changes can also affect inflammatory responses and adaptive immunity and can even contribute to metabolic disorders (Belizario et al, 2018). Inflammation is part of a multifaceted biological response to pathogens, damaged cells or irritants (Chen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

et al. 2020

View full text Add to dashboard Cite

Significant evidence supports a relationship between the gut microbiome, inflammation, host response, and health, including the finding that a number of disorders are associated with disruption of the microbiome. In these disorders, a number of dietary interventions (including prebiotics, live probiotics, or heat-killed microbes) have been proposed to be curative or preventative agents. The use of heat-killed microbes has a number of benefits over living organisms, including reduced infection risk in vulnerable individuals, extended shelf life and the potential for use in combination with antimicrobial agents. We previously reported that murine chow supplemented with 5% ADR-159, a heat-treated fermentate generated by two Lactobacillus strains, altered both behavior and the microbiome of male mice. Now we show that ADR-159 fed female mice also display a similar microbiome shift as determined by 16S rDNA analysis. In particular, we observed a reduction of levels of Turicibacter and Clostridium sensu stricto. These subtle changes in the bacterial component of the microbiome were mirrored by changes in the virome. Extended consumption of the ADR-159 diet had no negative effect on general health and lipocalin 2 levels (LCN2; a proxy for inflammation), but we observed increased IL-17f and decreased IL-12α expression in the colon and decreased short chain fatty acid levels in the ADR-159 fed animals. Four weeks into the diet, half of the animals were dosed with Citrobacter to determine the effect of ADR-159 on infection and on pathogen induced colitis. Overall, our results suggest that while the ADR-159 diet does not prevent Citrobacter infection, it had an effect on Citrobacter-induced inflammation. In contrast to animals fed standard chow, ADR-159 fed animals did not show a reduction of small intestine length and increase of colon crypt depth, which occurred in control mice. These microbiological, histological, and immunological results provide evidence to support the impact of heat-treated microorganisms and their metabolites on the murine microbiome and health.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Abnormalities in the gut microbiome are associated with perturbations in systemic immune reaction (Belizario et al, 2018) and predisposition to atopic disease such as asthma and eczema (Zimmermann et al, 2019). While several genetic (Sherrill and Rothenberg, 2011), environmental (Hill and Spergel, 2018) and esophageal microbiome (Benitez et al, 2015;Harris et al, 2015;Norder Grusell et al, 2018) factors have been implicated in EoE, there is evidence that supports a role for the gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

“…

Abnormalities in the gut microbiome are associated with suppressed Th2 response (Belizario et al, 2018 Mediators Inflamm. 2018 and predisposition to atopic disease such as asthma and eczema.

…”

mentioning

confidence: 99%

A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis

et al. 2019

View full text Add to dashboard Cite

Abnormalities in the gut microbiome are associated with suppressed Th2 response (Belizario et al., 2018 Mediators Inflamm. 2018:2037838) and predisposition to atopic disease such as asthma and eczema. We investigated if this applies to eosinophilic esophagitis (EoE). Stool bacterial DNA was extracted and followed by 16S rRNA amplification from 12 patients with eosinophilic esophagitis and 12 controls. Alpha‐ and beta‐diversity were analyzed. Only two patients had asthma or atopy and one patient was on budesonide. No patients were on PPIs. Patients with EoE had lower gut microbiota alpha diversity (species richness, P = 0.09; Shannon index, P = 0.01). The microbial composition was distinct as evidenced by significantly different beta diversity (P = 0.03) when compared to healthy controls. There were also significant differences in relative abundance at multiple taxonomic levels when comparing the two communities; at the phylum level, we observed a marked decrease in Firmicutes and increase in Bacteroidetes and at the order and family level there were significant decreases in Clostridia and Clostridiales in patients with EoE (q ≤ 0.1). We conclude that there are significant differences in microbial community structure, microbial richness, and evenness and a significant decrease in taxa within the Clostridia in patients with EoE. Our data suggest that Clostridia based interventions could be tested as adjuncts to current therapeutic strategies in EoE.

show abstract

“…др. [14,20,30]. Биохимическим маркером нарушений при дисбиозе являются короткоцепочечные жирные кислоты, КЦЖК, которые вырабатываются микробиотой в процессах метаболизма из пищевых волокон и служат источником энергии для хозяина.…”

unclassified

Microbiota and Network Medicine

Semidotskaya¹,

Chernyakova²,

Neffa³

et al. 2019

Shidnoevr. z. vnutr. simejnoi med.

View full text Add to dashboard Cite

Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases

Cited by 212 publications

References 99 publications

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis

Microbiota and Network Medicine

Contact Info

Product

Resources

About