Gut Microbiome Dynamics Over a Course of Kidney Transplantation: Preliminary Results of a Pilot Study

Stoma, Igor; Модулева, Е. А.; Губанова, Т. Г.; Iskrou, Ihar; Karpov, Igor; Krivenko, Svetlana; Штурич, И. П.; Kalachyk, Oleg; Uss, Anatoly; Руммо, О. О.

doi:10.1097/01.tp.0000699336.48313.1e

Cited by 2 publications

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“…Checkpoint inhibitor therapy is a type of cancer immunotherapy that targets and binds to key immune checkpoint proteins, thereby blocking T-cell inhibitory responses, restoring immune function, and consequently directing the immune system against malignant cells (199)(200)(201). The authors reported an association between higher microbial diversity and optimistic treatment outcomes, a finding in agreement with observations made in studies investigating allograft maintenance outcomes in the context of different human microbiotas (141,143,(202)(203)(204). The metagenomic implications of different chemotherapeutic as well as dietary interventions in renal cell carcinoma patients is an area of active investigation.…”

Section: Renal Transplantationsupporting

confidence: 75%

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Sen

Thummer

2022

Front. Immunol.

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The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interactions between the residents of the various human microbiotas and the human body. Since the gut microbiota is the densest, most popular, and most studied human microbiota, the impact of other human microbiotas such as the oral, lung, urinary, and genital microbiotas is often overshadowed. However, these microbiotas also provide critical and unique insights pertaining to transplantation success, rejection risk, and overall host health, across multiple different transplantation scenarios. Organ transplantation as well as the pre-, peri-, and post-transplant pharmacological regimens patients undergo is known to adversely impact the microbiotas, thereby increasing the risk of adverse patient outcomes. Over the past decade, holistic approaches to post-transplant patient care such as the administration of clinical and dietary interventions aiming at restoring deranged microbiota community structures have been gaining momentum. Examples of these include prebiotic and probiotic administration, fecal microbial transplantation, and bacteriophage-mediated multidrug-resistant bacterial decolonization. This review will discuss these perspectives and explore the role of different human microbiotas in the context of various transplantation scenarios.

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Section: Renal Transplantationsupporting

confidence: 75%

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Sen

Thummer

2022

Front. Immunol.

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Experience of using modern genomic technologies to study microorganisms and their communities

Воропаев

Stoma

Tapalski

2021

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Objective. The aim of this work was to review the main results of genomic studies of microorganisms and their communities performed on the base of the Research Laboratory of Gomel State Medical University.Materials and methods. Genomic, transcriptomic and metagenomic analysis of the microorganisms of the stomach and respiratory tract.Results. The capabilities of modern next-generation sequencing platforms have been analyzed, and the authors` own results of the use of genomic, transcriptomic and metagenomic analysis of the microbiota in patients with various gastric and respiratory pathologies have been described.Conclusion. The analysis of the obtained data has revealed peculiarities of the structure of the microbial communities of the stomach of the patients infected with H. pylori with different gastric pathology: the proportion participation of H. pylori in the metagenome of the samples with different forms of gastric cancer did not exceed 25 %, of gastritis — 6 %, of peptic ulcer — 1 %. At the same time, the minimal amount of H. pylori in all the cases could reach 0.1 %. A signifcant degree of CagA and CagY loci variability of H. pylori was detected. Streptoccocus genus bacteria dominated (36 %) in the bacterial microbiome of a patient diagnosed with the coronavirus disease, and in the viral microbiome, SARS-CoV-2 constituted 59 % of the total number of viruses in the material. The analysis of 13 strains of Klebsiella pneumoniae with multiple and extreme resistance to antibiotics has found that the studied strains belong to fve MLST-types, three of which are classifed as high epidemic risk groups.

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Gut Microbiome Dynamics Over a Course of Kidney Transplantation: Preliminary Results of a Pilot Study

Cited by 2 publications

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The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation

Experience of using modern genomic technologies to study microorganisms and their communities

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