Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease

Hui, Haochen; Wang, Zhuoya; Zhao, Xin; Xu, Lina; Yin, Lianhong; Wang, Feifei; Qu, Liping; Peng, Jinyong

doi:10.1016/j.jpha.2023.08.003

Cited by 5 publications

(2 citation statements)

References 50 publications

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“…Methylation of DMOLP-3 was performed using a previously described method ( Hui et al, 2023 ). In this method, methylated polysaccharide samples are first hydrolysed with 2 M trifluoroacetic acid (TFA) for 90 min.…”

Section: Methodsmentioning

confidence: 99%

Effects of UV/H2O2 degradation on Moringa oleifera Lam. leaves polysaccharides: Composition, in vitro fermentation and prebiotic properties on gut microorganisms

Yang,

Tao,

Wang

et al. 2024

Food Chemistry: X

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Section: Methodsmentioning

confidence: 99%

Effects of UV/H2O2 degradation on Moringa oleifera Lam. leaves polysaccharides: Composition, in vitro fermentation and prebiotic properties on gut microorganisms

Yang,

Tao,

Wang

et al. 2024

Food Chemistry: X

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“…Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a relapsing autoimmune disorder of the gut ( 1 , 2 ). The current strategy for IBD treatment is the use of immunosuppressive drugs to suppress the overactive immune system ( 3 , 4 ). However, these strategies do not provide adequate symptomatic relief, with 75% of patients with Crohn’s disease and 23 to 45% of patients with ulcerative colitis requiring surgical removal of portions of the gastrointestinal tract ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

Zhang,

Song,

et al. 2024

Sci. Adv.

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The artificial mucus layer, such as hydrogels, used to repair the damaged intestinal barrier, is a promising treatment for inflammatory bowel disease (IBD). However, the currently reported hydrogel-based artificial barriers are administered via rectal injection, causing unnecessary discomfort to patients. Herein, we report an oral hydrogel precursor solution based on thiol-modified hyaluronic acid (HASH). Owing to the reactive oxygen species (ROS)–responsive gelling behavior, our precursor solution formed an artificial mucus coating over the inflamed regions of the intestines, blocking microbial invasion and reducing abnormally activated immune responses. Notably, HASH also modulated the gut microbiota, including increasing the diversity and enhancing the abundance of short-chain fatty acid–associated bacteria, which play a key role in gut homeostasis. We believe that the ROS-responsive artificial mucus layer is a promising strategy for the oral treatment of IBD.

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Study on characterization of Bupleurum chinense polysaccharides with antioxidant mechanisms focus on ROS relative signaling pathways and anti-aging evaluation in vivo model

Feng,

Zhao,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease

Cited by 5 publications

References 50 publications

Effects of UV/H2O2 degradation on Moringa oleifera Lam. leaves polysaccharides: Composition, in vitro fermentation and prebiotic properties on gut microorganisms

Effects of UV/H2O2 degradation on Moringa oleifera Lam. leaves polysaccharides: Composition, in vitro fermentation and prebiotic properties on gut microorganisms

Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

Study on characterization of Bupleurum chinense polysaccharides with antioxidant mechanisms focus on ROS relative signaling pathways and anti-aging evaluation in vivo model

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