Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease
Guangshuai Zhang,
Dandan Song,
Ruilong Ma
et al.
Abstract:The artificial mucus layer, such as hydrogels, used to repair the damaged intestinal barrier, is a promising treatment for inflammatory bowel disease (IBD). However, the currently reported hydrogel-based artificial barriers are administered via rectal injection, causing unnecessary discomfort to patients. Herein, we report an oral hydrogel precursor solution based on thiol-modified hyaluronic acid (HASH). Owing to the reactive oxygen species (ROS)–responsive gelling behavior, our precursor solution formed an a… Show more
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