Gut-derived fungemia due to Kodamaea ohmeri combined with invasive pulmonary aspergillosis: a case report

Li, Zi-Mu; Kuang, Yukun; Zheng, Yifan; Xu, Peihang; Wang, Jiyu; Gan, Run-Jing; Li, Huixia; Bai, Lihong; Can-mao, Xie; Tang, Ke-Jing

doi:10.1186/s12879-022-07866-6

Cited by 2 publications

(2 citation statements)

References 53 publications

(34 reference statements)

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“…K.ohmeri is considered to be an emerging and rare fungal pathogen that can cause invasive infections such as peritonitis, endocarditis, urinary tract infection, ear infection, cellulitis, fungemia, tinea onychomycosis, pneumonia, keratitis, oral diseases, and disseminated infections, with high mortality rates due to fungal bacteraemia, especially in children [1][2][3] Molecular epidemiological information on K. ohmeri isolates is currently unavailable, and studies have speculated that their wide range of infection types may be related to the underlying genomic diversity that allows K. ohmeri to adapt to a variety of human sites and tissues [4] . This microbe has been found in patients around the world, with nearly 70% of infections occurring in Asia (especially East and Southeast Asia), but its regional and ethnic heterogeneity is unknown due to the low number of reported cases.…”

Section: Discussionmentioning

confidence: 99%

A Case of Septic Shock due to Kodamaea Ohmeri

Mao,

Cao,

Zhang

et al. 2024

Preprint

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Kodamaea ohmeri is an emerging rare fungal pathogen that often infects patients with weakened immunity. Herein, we report a case of a patient with normal immune function infected with K.ohmeri. The patient presented with fever, shortness of breath and lethargic (accompanied by septic shock in one episodes) within two weeks. Chest roentgenography showed massive right-side pleural effusion and atelectasis, and left-side pneumonia. Thoracentesis yielded pleural effusion containing a nucleated cell count of more than 600·106·L-1. An bronchoalveolar lavage fluid culture grew K.ohmeri. According to the result of drug sensitivity, voriconazole was used for anti-fungal treatment.The patient died after medical treatment. Early and accurate identification of K. ohmeri is critical to determining treatment options. Septic shock caused by severe fungal pneumonia requires early, aggressive and multidisciplinary treatment.

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Section: Discussionmentioning

confidence: 99%

A Case of Septic Shock due to Kodamaea Ohmeri

Mao,

Cao,

Zhang

et al. 2024

Preprint

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“…nitidulidarum and Ko. restingae, is also an emerging human pathogen with a significant mortality rate [113][114][115] .…”

Section: Cactophily As a Launching Pad For The Emergence Of Opportuni...mentioning

confidence: 99%

Diverse signatures of convergent evolution in cacti-associated yeasts

Gonçalves,

Harrison,

Steenwyk

et al. 2023

Preprint

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Many distantly related organisms have convergently evolved traits and lifestyles that enable them to live in similar ecological environments. However, the extent of phenotypic convergence evolving through the same or distinct genetic trajectories remains an open question. Here, we leverage a comprehensive dataset of genomic and phenotypic data from 1,049 yeast species in the subphylum Saccharomycotina (Kingdom Fungi, Phylum Ascomycota) to explore signatures of convergent evolution in cactophilic yeasts, ecological specialists associated with cacti. We inferred that the ecological association of yeasts with cacti arose independently ~17 times. Using machine-learning, we further found that cactophily can be predicted with 76% accuracy from functional genomic and phenotypic data. The most informative feature for predicting cactophily was thermotolerance, which is likely associated with duplication and altered evolutionary rates of genes impacting the cell envelope in several cactophilic lineages. We also identified horizontal gene transfer and duplication events of plant cell wall-degrading enzymes in distantly related cactophilic clades, suggesting that putatively adaptive traits evolved through disparate molecular mechanisms. Remarkably, multiple cactophilic lineages and their close relatives are emerging human opportunistic pathogens, suggesting that the cactophilic lifestyle - and perhaps more generally lifestyles favoring thermotolerance - may preadapt yeasts to cause human disease. This work underscores the potential of a multifaceted approach involving high throughput genomic and phenotypic data to shed light onto ecological adaptation and highlights how convergent evolution to wild environments could facilitate the transition to human pathogenicity.

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Gut-derived fungemia due to Kodamaea ohmeri combined with invasive pulmonary aspergillosis: a case report

Cited by 2 publications

References 53 publications

A Case of Septic Shock due to Kodamaea Ohmeri

A Case of Septic Shock due to Kodamaea Ohmeri

Diverse signatures of convergent evolution in cacti-associated yeasts

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