Gut-bone Cross Talks and Implications in Celiac Disease

Lerner, Aaron; Tenbusch, Matthias

doi:10.12691/ijcd-4-1-4

Cited by 17 publications

(17 citation statements)

References 52 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Butyrate has beneficial effects on intestinal barrier integrity, as it enhances the expression of tight junction proteins. Moreover, it helps prevent deleterious intestinal permeability and bacterial translocation, thereby exerting a protective influence on the initiation of pro- inflammatory responses ( 106 , 108 , 109 ). To relevance in collagen-induced arthritis, an animal model of RA, butyrate is able to suppress RA features and this is achieved via a butyrate- mediated increase of IL-10 producing Tregs and a decrease of Th17 ( 110 ).…”

Section: Adherence In Meddiet and Its Effects On Microbiome Related T...mentioning

confidence: 99%

Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience

Tsigalou,

Tsolou,

Stavropoulou

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

The nutritional habits regulate the gut microbiota and increase risk of an autoimmune disease. Western diet is rich in sugars, meat, and poly-unsaturated fatty acids, which lead to dysbiosis of intestinal microbiota, disruption of gut epithelial barrier and chronic mucosal inflammation. In contrast, the Mediterranean Diet (MedDiet) is abundant in ω3 fatty acids, fruits, and vegetables, possessing anti-inflammatory properties that contribute to the restoration of gut eubiosis. Numerous studies have extensively examined the impact of MedDiet and its components on both health and various disease states. Additionally, specific investigations have explored the correlation between MedDiet, microbiota, and the risk of autoimmune diseases. Furthermore, the MedDiet has been linked to a reduced risk of cardiovascular diseases, playing a pivotal role in lowering mortality rates among individuals with autoimmune diseases and comorbidities. The aim of the present review is to specifically highlight current knowledge regarding possible interactions of MedDiet with the patterns of intestinal microbiota focusing on autoimmunity and a blueprint through dietary modulations for the prevention and management of disease’s activity and progression.

show abstract

Section: Adherence In Meddiet and Its Effects On Microbiome Related T...mentioning

confidence: 99%

Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience

Tsigalou,

Tsolou,

Stavropoulou

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Due to recent expanding knowledge on the two entities, on the central role played by nutrients, microbiome, IgA metabolism and functions and the mucosal and systemic immune systems [1][2][3][4]17,[28][29][30], cross-talks between the two diseases, were discovered [16,18,[29][30][31][32][33]. Table 1 summarizes the epidemiological, clinical and pathophysiological aspects of CD and IgAN.…”

Section: Similarities and Dissimilarities Between Celiac Disease And mentioning

confidence: 99%

“…The gut-kidney axis is a part of a much wider network, centered in the gut and irradiating to remote organs, conveying the messages of loss of tolerance and autoimmunogenesis [1][2][3][4]. This axis appears crucial in IgA nephropathy (IgAN) physiopathology [5].…”

Section: Introductionmentioning

confidence: 99%

Gluten, Transglutaminase, Celiac Disease and IgA Nephropathy

Lerner¹,

Berthelot²,

Jeremias³

et al. 2017

J Clin Cell Immunol

Self Cite

View full text Add to dashboard Cite

Both, celiac disease and IgA nephropathy are autoimmune diseases that are IgA mediated and share multiple clinical, pathophysiological, genetic, nutritional and immunological aspects. In view of recent observations and wider understanding of the central role played by the intestinal ecosystem in celiac disease and IgA nephropathy development, the present review highlights those shared aspects, concentrating on potential nutritional therapeutic strategies in IgA nephropathy.

show abstract

“…Their food related problems might reflect an adverse additive effect of multiple modest hypersensitivity reactions mediated, for instance, by food originated immune complexes promoting autoimmune reactions in the joints [54].…”

Section: Gut-joint Axismentioning

confidence: 99%

GUT-the Trojan Horse in Remote Organs’ Autoimmunity

T¹

2016

J Clin Cell Immunol

View full text Add to dashboard Cite

Human beings assemble and maintain a diverse but host-specific gut microbial community along the longitudinal axis of the intestines. Helped by a functional tight junction, the default response to commensal microbes is tolerance, whereas the default response to pathogens is an intricately orchestrated immune response, resulting in pathogen clearance. Nutrients and industrial food additives were suggested to impact the intestinal ecosystem and to breach tight junction integrity. Taken together, certain nutritional components, increased intestinal permeability, disease specific dysbiotic pathobionts and their capacity of post translation modification of proteins, are luminal events that impact autoimmunogenesis. The present review expands on the multi gut originated axes and their relationship to remote organ autoimmune diseases. Brain, joint, bone, endocrine, liver, kidney, heart, lung and skin autoimmune diseases are connected to the intestinal luminal compartmental deregulated events to form the gut-systemic organs axes.

show abstract

Gut-bone Cross Talks and Implications in Celiac Disease

Cited by 17 publications

References 52 publications

Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience

Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience

Gluten, Transglutaminase, Celiac Disease and IgA Nephropathy

GUT-the Trojan Horse in Remote Organs’ Autoimmunity

Contact Info

Product

Resources

About